Mucosal immunization in perspective

Rose, Markus A.

doi:10.4161/hv.29609

Cited by 10 publications

(9 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The recent discovery of shared IgA antibody sequences in both the serum and the gut further supports the connection between steady-state circulating IgA-secreting cells and mucosa-localized cells (23). This possible shared origin, combined with the enhanced neutralization capacity of IgA antibodies, makes them an ideal target population for vaccines aimed to induce localized mucosal protection (24)(25)(26)(27)(28)(29). This current goal in vaccine development is based on the hypothesis that localized protective antibodies would prevent initial infection of the host, reducing the pathogen burden and the need for neutralizing serum IgG antibodies.…”

Section: Resultsmentioning

confidence: 85%

Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination

Neu¹,

Guthmiller²,

Huang³

et al. 2018

Journal of Clinical Investigation

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 85%

Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination

Neu¹,

Guthmiller²,

Huang³

et al. 2018

Journal of Clinical Investigation

View full text Add to dashboard Cite

“…Compared to systemic immunization, mucosal immunization efficiently induces a local mucosal immune response ( 102 ), which can induce “frontline immunity” with local Igs production in the MALT, neutralizing pathogens and finally preventing infection ( 103 ). Additionally, mucosal vaccines are superior to systemic vaccines from a production and regulatory standpoint ( 104 ).…”

Section: Immunoglobulin Responses Following Mucosal Immunizationmentioning

confidence: 99%

Immunoglobulins, Mucosal Immunity and Vaccination in Teleost Fish

et al. 2020

View full text Add to dashboard Cite

Due to direct contact with aquatic environment, mucosal surfaces of teleost fish are continuously exposed to a vast number of pathogens and also inhabited by high densities of commensal microbiota. The B cells and immunoglobulins within the teleost mucosa-associated lymphoid tissues (MALTs) play key roles in local mucosal adaptive immune responses. So far, three Ig isotypes (i.e., IgM, IgD, and IgT/Z) have been identified from the genomic sequences of different teleost fish species. Moreover, teleost Igs have been reported to elicit mammalian-like mucosal immune response in six MALTs: gut-associated lymphoid tissue (GALT), skin-associated lymphoid tissue (SALT), gill-associated lymphoid tissue (GIALT), nasal-associated lymphoid tissue (NALT), and the recently discovered buccal and pharyngeal MALTs. Critically, analogous to mammalian IgA, teleost IgT represents the most ancient Ab class specialized in mucosal immunity and plays indispensable roles in the clearance of mucosal pathogens and the maintenance of microbiota homeostasis. Given these, this review summarizes the current findings on teleost Igs, MALTs, and their immune responses to pathogenic infection, vaccination and commensal microbiota, with the purpose of facilitating future evaluation and rational design of fish vaccines.

show abstract

“…Sows vaccinated orally with live attenuated PEDV induced better passive protection to piglets compared to the same vaccine administered by intramuscular injection [15]. Several studies showed that mucosal immunity is induced effectively when vaccines are delivered at the mucosal surface [19], where microfold (M) cells take up and transport the antigens to dendritic cells and macrophages in the local lymph nodes to initiate antigen specific immune response. In addition, antigen specific response activated at a specific mucosal surface, such as intestine, can mediate an effector response at a distant site.…”

Section: Plos Onementioning

confidence: 99%

Immune responses to porcine epidemic diarrhea virus (PEDV) in swine and protection against subsequent infection

et al. 2020

View full text Add to dashboard Cite

Understanding the immune responses against Porcine epidemic diarrhea virus (PEDV) is important to prevent infection and to design control strategies. We evaluated both systemic and mucosal immune responses to PEDV in pigs and assessed if prior exposure to virus protects against re-infection. Three-week-old pigs were infected with PEDV and immune response in blood, intestine, and mesenteric lymph node (MLN) was evaluated. At 30 dpi, virus exposed pigs were challenged with a field isolate of PEDV and immune response at 5 d post challenge was evaluated. We found that PEDV RNA persists in the intestine even after fecal shedding of the virus was stopped at 28 dpi and pigs previously exposed to PEDV are protected from virus shedding after re-infection. PEDV infection induced both humoral and cell mediated immune response with an increase in PEDV specific IgA and IgG antibodies in intestine and serum. Flow cytometry analysis showed a significantly higher frequency of B cells and lower frequency of T cells at 4 dpi. The frequency of CD4/CD8 double positive (DP) memory T cells was significantly increased in the MLN of challenged animals. These studies may provide further insights into understanding the mucosal immune response to PEDV and its role in protection against disease. OPEN ACCESS Citation: Krishna VD, Kim Y, Yang M, Vannucci F, Molitor T, Torremorell M, et al. (2020) Immune responses to porcine epidemic diarrhea virus (PEDV) in swine and protection against subsequent infection. PLoS ONE 15(4): e0231723. https://doi.Rectal swab samples were collected daily using BBL TM CultureSwab TM collection and transport system (Becton Dickinson and Co, Sparks, MD). Each swab was suspended in PLOS ONEImmune response to PEDV in swine PLOS ONE | https://doi.

show abstract

Mucosal immunization in perspective

Cited by 10 publications

References 15 publications

Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination

Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination

Immunoglobulins, Mucosal Immunity and Vaccination in Teleost Fish

Immune responses to porcine epidemic diarrhea virus (PEDV) in swine and protection against subsequent infection

Contact Info

Product

Resources

About