Mucosal cysts in the gastrointestinal tract of beagle dogs

Abstract

Mucosal cysts were observed microscopically in the duodenum, jejunum and, to a lesser extent, stomach and large intestine in 102 out of 236 beagle dogs examined. These dogs were used in toxicity studies or had died spontaneously in a breeding colony. The cysts were lined by intestinal epithelium and filled mainly with cellular debris and mucus. Pathogenesis and aetiology of the lesion are unknown. SCHLEIMHAUTCYSTEN 1M VERDAUUNGSTRAKT VON BEAGLE-HUNDEN Schleimhautcysten wurden mikroskopisch im Duodenum, Jejunum und, in kleinerem Ma~e, im Magen und Dickdarm bei 102 von 236 untersuchten Beagle-Hunden beobachtet. Diese Hunde wurden in Studien tiber Toxizitat benutzt, oder sie waren spontan in einer Zuchtkolonie gestorben. Die Cysten waren mit Darmepithelium umgeben, und .~nthielten hauptsachlich Zellenreste und Schleim. Die Pathogenese und Atiologie der Lesionen sind nicht bekannt. KYSTES DE LA MEMBRANE MUQUEUSE DANS LE TUBE D1SEGTlF DES CHIENS BEAGLE Des kystes de la membrane muqueuse furent observes sous microscope dans Ie duodenum, jejunum et, en moins grande mesure, dans I'estomac et Ie gros intestin de 102 sur 236 chiens Beagle examines. Ces chiens furent utilises pour des etudes de toxicite, ou etaient morts spontanement dans une colonie d'elevage. Les kystes etaient bordes d'epithelium intestinal et remplis principalement de debris cellulaire et de mucus. On ignore la pathogenese et I'etiologie de la lesion.

Intestinal Crypt Lesions Associated with Protein-Losing Enteropathy in the Dog

“…First, the protein status of these other dogs was not reported; they may or may not have had PLE. However, even assuming that these dogs 39,51 did not have PLE, we propose that the question of whether the crypt lesions can cause or be associated with PLE centers more on their number and severity (or other, unknown factors) rather than merely on their presence or absence. A similar example of such a situation is gastric infection with Helicobacter pylori.…”

“…Of 236 Beagles that had been used in toxicity studies or had died spontaneously, 102 had lesions that were similar to ours. 51 In general, 1 section each of duodenum, jejunum, and ileum were examined. Dogs that had such cysts typically had 1-3 cysts per section of tissue, although occasional dogs had many.…”

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog

“…Mucosal cysts appear more common in duodenum and jejunum than large intestine and are supposed to be acquired as part of degenerative process. 37…”

“…Mucosal cysts appear more common in duodenum and jejunum than large intestine and are supposed to be acquired as part of degenerative process. 37 Salivary Glands Table 4.4 summarizes the suggested nomenclature for nonproliferative and nonneoplastic proliferative changes of the salivary glands.…”