Mucosal changes associated with adenocarcinoma of the colon and rectum

Arminski, T. C.; McLean, D. W.

doi:10.1007/bf02589859

Cited by 6 publications

(3 citation statements)

References 4 publications

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“…Considering only neoplastic polyps in the present series the difference between the sexes was less, as the women had a slightly higher proportion of such polyps (45 against 32 per cent). The incidence of adenomatous growths in cases with colonic carcinoma is reported to be doubled (2). It might thus be suggested that the relatively large proportion of diminutive polyps of neoplastic type in our series would be related to the fact that most of the patients have also had large neoplastic polyps or carcinoma in the colon.…”

Section: Incidence Of Neoplastic Diminutive Polypsmentioning

confidence: 65%

Diminutive Colonic Polyps – Clinical Significance and Management

Granqvist¹,

Gabrielsson²,

Sundelin³

1979

Endoscopy

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Of 300 diminutive polyps (up to 5 mm) found at colonoscopy, 114 were neoplastic (37 per cent) and thus possible precursors of carcinoma. This suggests that all colonic polyps, regardless of size, should if possible be extirpated or coagulated. As polyps of this small size often escape detection roentgenologically, especially by conventional technique, colonoscopy should be extended to involve the entire colon. This is because diminutive polyps, especially of neoplastic type, are common also in the proximal part of the colon.

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Section: Incidence Of Neoplastic Diminutive Polypsmentioning

confidence: 65%

Diminutive Colonic Polyps – Clinical Significance and Management

Granqvist¹,

Gabrielsson²,

Sundelin³

1979

Endoscopy

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“…This is close to the 35% found in the present study. Most other studies have shown lower prevalence rates-15 to 24.5% (Spratt, Ackerman & Moyer 1958, Shepard & Jones 1971, Weir 1973, Sat0 1974), but Arminski & McLean (1972 found adenomas in patients with colorectal cancer in 57 of 100 resected specimens. Even higher rates were found when multiple synchronous carcinomas were present.…”

Section: Discussionmentioning

confidence: 94%

Prevalence and morphological features of adenomas of the large intestine in individuals with and without colorectal carcinoma

Eide

1986

Histopathology

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The presence of adenomas in 164 surgical specimens of the large intestine from 81 males and 83 females with colorectal carcinomas was compared with the presence of adenomas in a general necropsy population in northern Norway. In the group of patients with colorectal carcinomas the observed prevalence of single or multiple adenomas was 5.9 times higher than expected from the prevalence in the general necropsy population. The observed-to-expected ratios of all adenomas (4.7), adenomas with villous elements (4.6), adenomas with moderate or severe grades of dysplasia (4.9) and adenomas 10 mm or larger (5.5) were also higher in the surgical series. The study indicates that factors which initiate the growth of adenomas and, to a minor degree, factors which promote the growth of adenomas to a large size are more prevalent in individuals with colorectal carcinoma than in the necropsy population. Factors determining the presence of villous elements and the grades of dysplasia of adenomas seem to operate similarly in adenoma-bearing patients with and without colorectal carcinoma.

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“…We have distinguished adenocarcinoma and papillary carcinoma, as it has been shown that the prognosis may differ in the two groups. 1 We recognize the distinction between extra-and intra-cellular mucoid carcinoma,31 but only classify the former as mucoid, and then only i f 50% or more of the tumor cells are floating free in lakes of mucin. We have attempted to grade them all.…”

Section: Cancer A1 #!Gust 1971mentioning

confidence: 99%

Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma

Filipe¹,

Branfoot²

1974

Cancer

233

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Our previous studies have shown that histologically normal mucosa adjacent to carcinomas of the large intestine is often abnormal histochemically. This „transitional”︁ mucosa, as we termed it, is characterized by an increase of sialomucins, accompanied usually by a decrease or absence of the sulphomucins which are predominant in the normal mucosa of the large intestine. The extent and intensity of these mucin changes were not clear, and so we have mapped them by cutting strips of mucosa from the whole length of 25 surgical specimens. This work confirms that the pattern of mucus secretion is altered around carcinomas, but also shows similar changes in patches of mucosa at a distance from frank tumors. The increase in sialomucins is directly related to the extent of invasion by a carcinoma according to Dukes' classification, but not to its degree of differentiation or to its histologic pattern. It is suggested that the mucin changes may reflect a transformation to a fetal type of epithelium and indicate an early stage in carcinogenesis. The practical value of these findings in diagnosis and prognosis is discussed.

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Mucosal changes associated with adenocarcinoma of the colon and rectum

Cited by 6 publications

References 4 publications

Diminutive Colonic Polyps – Clinical Significance and Management

Diminutive Colonic Polyps – Clinical Significance and Management

Prevalence and morphological features of adenomas of the large intestine in individuals with and without colorectal carcinoma

Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma

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