Prevalence and morphological features of adenomas of the large intestine in individuals with and without colorectal carcinoma

Eide, Tor J.

doi:10.1111/j.1365-2559.1986.tb02467.x

Cited by 38 publications

(12 citation statements)

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“…One autopsy study noted a stronger association between serrated lesions and colorectal cancer than between adenomas and cancer (105), which was also found in one endoscopic study (92). …”

Section: Epidemiology Of Serrated Lesionsmentioning

confidence: 56%

Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel

Rex

Ahnen

Baron

et al. 2012

American Journal of Gastroenterology

987

1,121

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“…One autopsy study noted a stronger association between serrated lesions and colorectal cancer than between adenomas and cancer (105), which was also found in one endoscopic study (92). …”

Section: Epidemiology Of Serrated Lesionsmentioning

confidence: 56%

Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel

Rex

Ahnen

Baron

et al. 2012

American Journal of Gastroenterology

987

1,121

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“…A higher prevalence of hyperplastic polyps has been found in patients with colorectal cancer compared with those without colorectal cancer. 19 One study found an increased probability of neoplastic polyps in the same segment of the colon as the hyperplastic lesion. 28 These findings support the view of an association between hyperplastic polyps and colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…During the surveillance period we noted that hyperplastic polyps were frequent findings in the subjects under surveillance. A higher prevalence of hyperplastic polyps has previously been found in patients with colorectal carcinoma compared with those without colorectal carcinoma, 19 suggesting that hyperplastic polyps are associated with a risk of colorectal cancer. We have previously shown that adenomas in subjects with an increased risk of colorectal cancer identify risk individuals predisposed to colorectal cancer.…”

mentioning

confidence: 93%

Prevalence and incidence of hyperplastic polyps and adenomas in familial colorectal cancer: correlation between the two types of colon polyps

Liljegren

Lindblom²,

Rotstein³

et al. 2003

Gut

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Background and aims: Colorectal adenomas are recognised as precursors of colorectal carcinomas. The significance of hyperplastic (metaplastic) colorectal polyps is unknown. The relationship between hyperplastic polyps and adenomas, and the prevalence and incidence of these lesions were evaluated in individuals predisposed to familial colorectal cancer. Methods: A total of 299 individuals participating in our surveillance programme during 1990-2000 were retrospectively evaluated. Subjects were classified into three groups: hereditary non-polyposis syndrome (HNPCC) (n=108), hereditary colorectal cancer (HCRC) (n=127), and individuals with empirical risk estimates-two close relatives (TCR) (n=64). Findings from 780 colonoscopies were evaluated regarding prevalence and incidence of hyperplastic polyps and adenomas. Correlations between hyperplastic polyps and adenomas were calculated by Pearson correlation. Results: In total, 292 hyperplastic polyps and 186 adenomas were observed in 98 and 90 individuals, respectively. A positive correlation was found between the numbers of hyperplastic polyps and adenomas (r=0.40; p<0.001). Correlations between adenomas and hyperplastic polyps were similar in the three groups. The risk of detecting new hyperplastic polyps (odds ratio 5.41) or adenomas (OR 2.56) increased significantly when there was a positive finding at first colonoscopy. Conclusion: Hyperplastic polyps as well as adenomas may identify individuals with a high risk of colorectal cancer. This information is important when these individuals are selected and included in tailored surveillance programmes.

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“…At the index endoscopy, 42.6% of patients were defined as having high-risk polyps (Z 1 cm, a villous component, high-grade dysplasia; and/or three adenomas or more) (Eide, 1986;Atkin et al, 1992Atkin et al, , 1998Blumberg et al, 2000;Noshirwani et al, 2000) but also at follow-up endoscopies substantial numbers of patients were diagnosed with high-risk polyps (10.5-25.0%). The Funen adenoma follow-up study found advanced neoplasia (defined as a villous structure, > 1 cm in size or severe dysplasia) in 5.2 and 8.6% of patients re-examined 2 and 4 years, respectively, after colonoscopic polypectomy (Jorgensen et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

“…the five largest) polyps per patient were registered using the computerized reports of the Department of Pathology. 'High-risk' polyps were defined as the presence of adenomatous polyps with high-grade dysplasia, tubulovillous or villous histology, a polyp size of at least 1 cm and/or three or more polyps (Eide, 1986;Atkin et al, 1992;Atkin et al, 1998;Blumberg et al, 2000).…”

Section: Methodsmentioning

confidence: 99%

Endoscopic follow-up of 383 patients with colorectal adenoma: an observational study in daily practice

Jonkers

Ernst²,

Pladdet³

et al. 2006

European Journal of Cancer Prevention

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Endoscopic removal of colorectal adenomas reduces the incidence and mortality of colorectal cancer (CRC), but follow-up surveillance is recommended. Compliance with the Dutch surveillance guidelines and detection of neoplasia during follow-up has been evaluated in daily practice. From 1987 to 1996, 383 consecutive patients with colorectal adenomas (56.4% male, 61.8+/-11.3 years) were included and followed until December 2000. The mean follow-up was 80.5+/-42.5 months with 2.2+/-0.9 follow-up endoscopies. A total of 32.5 and 27.3% of follow-up endoscopies were performed >25% (time between advised and actual endoscopy) too late or too early, respectively. At the end of follow-up, 33.4% of patients had left the follow-up (two-thirds died) and 60.1% were known with co-morbidity. A first, second, third, fourth and fifth follow-up endoscopy had been performed in 327, 238, 132, 64 and 35 patients, respectively. Adenomatous polyps (with high-risk polyps) were detected in 100% (42.6%) of the index endoscopies and in 25.1% (17.4%), 23.9% (10.5%), 28.0% (12.1%), 34.4% (25.0%) and 37.1% (17.1%) of the first to fifth follow-up endoscopy, respectively. CRC was diagnosed in seven patients (46.1+/-22.9 months after index endoscopy), resulting in a standardized incidence ratio of 1.4 (confidence interval 0.6-3.0, P=0.4) compared to the general population. In this daily practice, high numbers of total and high-risk adenomatous polyps were found during follow-up surveillance. The incidence of CRC was not significantly different from the general population, which might be due to the intensive follow-up and removal of polyps. These findings support the importance of follow-up surveillance. However, the high overall morbidity and mortality should be taken into account when selecting patients for an intensive follow-up programme.

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Prevalence and morphological features of adenomas of the large intestine in individuals with and without colorectal carcinoma

Cited by 38 publications

References 10 publications

Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel

Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel

Prevalence and incidence of hyperplastic polyps and adenomas in familial colorectal cancer: correlation between the two types of colon polyps

Endoscopic follow-up of 383 patients with colorectal adenoma: an observational study in daily practice

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