MucoJet: A novel oral microjet vaccination system

Oral drug delivery for immunoengineering

“…101 This gas production increases the pressure to around ~30 kPa, providing the device with sufficient force to penetrate the mucosal layer and deliver a vaccine solution. 101 Aran et al utilized this technology to deliver ovalbumin to rabbits, which produced high titers of antigen-specific immunoglobulins G and A. Each of these mentioned strategies provide advanced progress in increasing the bioavailability of orally delivered drugs, thus, making it a more attractive means of drug delivery.…”

“… 99 The MucoJet is another example of a novel technology that has found success with in vivo animal studies to penetrate the mucosal layer via oral administration and elicit antibody production. 100 , 101 The MucoJet is a small immunotherapeutic delivery system consisting of a small plastic device that can be activated by the user by providing a pressure termed “click” in their work (Figure 7 ). 101 The polymeric membrane dissolves due to the “click,” causing the water reservoir to contact the chemical propellant (citric acid and sodium bicarbonate), generating carbon dioxide gas (Figure 7 ).…”

“… 100 , 101 The MucoJet is a small immunotherapeutic delivery system consisting of a small plastic device that can be activated by the user by providing a pressure termed “click” in their work (Figure 7 ). 101 The polymeric membrane dissolves due to the “click,” causing the water reservoir to contact the chemical propellant (citric acid and sodium bicarbonate), generating carbon dioxide gas (Figure 7 ). 101 This gas production increases the pressure to around ~30 kPa, providing the device with sufficient force to penetrate the mucosal layer and deliver a vaccine solution.…”

“… 101 The polymeric membrane dissolves due to the “click,” causing the water reservoir to contact the chemical propellant (citric acid and sodium bicarbonate), generating carbon dioxide gas (Figure 7 ). 101 This gas production increases the pressure to around ~30 kPa, providing the device with sufficient force to penetrate the mucosal layer and deliver a vaccine solution. 101 Aran et al utilized this technology to deliver ovalbumin to rabbits, which produced high titers of antigen‐specific immunoglobulins G and A.…”

A blueprint for recovery for the postcoronavirus (COVID‐19) world

“…Later when a vaccine becomes available, dentists could become key administrators of the vaccine (Miller & Greenberg, 2018). In the meanwhile, another layer of prevention could come from reducing potential infectiousness of patients through the use of an antiseptic protocol.…”