Mucoid alteration effects on synthetic calculus formation

Draus, F.J.; Miklos, F.L.; West, Benjamin A.

doi:10.1016/0003-9969(66)90158-0

Cited by 11 publications

(2 citation statements)

References 10 publications

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“…G ottschalk (1964) suggested an ion-exchange role of salivary glyco proteins while stored in the glands, absorbing calcium ions out of the blood stream. The calcium binding of a human sublingual glycoprotein may be of importance for calculus formation in vivo (Middleton, 1965;D raus, M iklos and W est, 1966). This is also stressed by the location of the main deposits of calculus on the lower incisors, where a rich supply of sublingual saliva is available.…”

Section: Discussionmentioning

confidence: 99%

The Calcium-Binding Effect of a Human Salivary Glycoprotein

Rölla¹,

Jonsen²

1967

Caries Res

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Section: Discussionmentioning

confidence: 99%

The Calcium-Binding Effect of a Human Salivary Glycoprotein

Rölla¹,

Jonsen²

1967

Caries Res

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“…In a study performed by Draus, Miklos, and West, in 1966" an extract of bovine submaxillary gland was altered by chemical and enzymatic treatment. The effects of these alterations on the formation of calculus in vitro were investigated by a technic of dipping similar to that described previously in 1963.'…”

Section: The Inhibition Of Calculusmentioning

confidence: 99%

Anticalculus Agents for the Treatment, Control, and Prevention of Periodontal Disease*

McNeal

1969

J Public Health Dent

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If you are interested in the eradication of calculus by drugs, read this comprehensive report and evaluation Practicall! , universal agreement exists among dentists that supragingival and subgingival calculus arc the major obstacles in the treatment and prevention of periodontal disease. The mechanical removal from the teeth of this yellow, calcified foreign material has consumed many dental hours during the decades that clinical dentistry has been practiced. If an agent capable of interfering n i t h the formation of calculus were developed and perfected, a significant step toxvard eradication of periodontal disease might be achieved. As interest in the problem of reducing periodontal disease increased during the past two decades, attempts to locate such an agent have produced significant amounts of data. The report that will follow has been plannctl to present a comprehensive review of the investigations that concern inhibitory agent 5.The procedure for this review will follow a definite pattern of objectives:to understand the points in the forniation of calculus for interference to take placeto report the significant investigations in detail by describing the procedures utilized then, ti critical a p p r a i d of the findings will be submitted to obtain a summary of the those gained from widely accepted hypotheses; and by citing the findings; present statii\ of anti-calculus agents and the anticipations for the early future.The Review of the Literature b'liile much remains unknown about the mechanisms associated in the formation of caiculus. a conmisu4 has been e5tablished that initially there is a deposition of soft, plaque material with large numbers of microorganisms trapped in a gel-like matrix probably derived from the bacteria and the saliva. Calcification of the organisms and the interbacterial matrix leads t o the solid inaterial recognized clinicallq-as calculus.60 1. The Process of Forming Calculus 'fheilade and S~h r o e d e r~~ have described the procedure further that is followed in the formation of calculus. Initially organic matter attaches to the clean smooth surfaces of teeth as a cuticle-like membraneone homogenous in structure and with a thickness of several microns, according to Tiireski. and his group.54 Theilade and Schroeder48 suggest that this cuticle origiriates from salivary proteins. The next step, as they report it is a soft deposit, several cells thick. that always is found on the surfaces of teeth before mineralization begins. Muhlemann antl S~h n e i d e r 3~ have observed Gram-positive coccoid or rod-like microorganisins and degenerating leukocytes during this initial stage of the deposit. Subsequently, they report the appearance and gro-wth of certain filamentous organisms in the substance of the plaque.Theilade antl Schroeder, with the aid of the electron microscope, have detected bacterial plaque \vith microorganisms embedded in the homogenous intermicrobial matrix ?*As the third step, mineralization begins as foci of small crystals in the intermicrobial matrix, Muhlemann ant...

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A sulphated glycopeptide in human supragingival calculus extracts

Embery

1977

Calc. Tis Res.

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A method is described for the isolation and purification of a sulphated glycopeptide from human supragingival calculus. The compound was isolated after using EDTA treatment, 2 M CaCl2 extraction, proteolytic digestion, ethanol precipitation, and finally purified by DEAE cellulose chromatography. It migrated as a single component of cellulose acetate electrophoresis, and chemical and infrared spectral analysis showed the presence of covalently attached sulphate groups. The sulphated glycopeptide was distinguished from being a sulphated glycosaminoglycan.

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Mucoid alteration effects on synthetic calculus formation

Cited by 11 publications

References 10 publications

The Calcium-Binding Effect of a Human Salivary Glycoprotein

The Calcium-Binding Effect of a Human Salivary Glycoprotein

Anticalculus Agents for the Treatment, Control, and Prevention of Periodontal Disease*

A sulphated glycopeptide in human supragingival calculus extracts

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