Mucoepidermoid Carcinoma Arising From Pleomorphic Adenoma of the Soft Palate

Abstract

Carcinoma arising in pleomorphic adenoma is a rare entity. A case of mucoepidermoid carcinoma in pleomorphic adenoma occurring in the soft palate of a 40-year-old woman is reported. An intraoral excision of the tumor was performed. Histopathological examination revealed high-grade mucoepidermoid carcinoma proliferated in pleomorphic adenoma with free surgical margin. The patient received adjuvant neck radiotherapy. She remains free of disease 16 months post-treatment.

Mucoepidermoid carcinoma ex pleomorphic adenoma: A rare diagnostically challenging entity

“…A total of fourteen MECxPA have been reported (including this case), of which, Contents lists available at ScienceDirect Oral Oncology journal homepage: www.elsevier.com/locate/oraloncology https://doi.org/10.1016/j.oraloncology.2022.106112 Received 29 August 2022; Accepted 1 September 2022 ten were high-grade MECxPA, three were low-grade and one was intermediate grade. Most lesions were located within the parotid gland while two were in the palate and one in the mandibular retromolar region [4,5]. Two were metastatic lesions within the parapharyngeal space [2,6].…”

Pleomorphic adenoma with extensive mucinous metaplasia mimicking mucoepidermoid carcinoma

“…On the other hand MEC may develop as a component of carcinoma ex PA. They are often high-grade and invasive [4].…”

“…These morphological variations of PA may show similarity with other benign and malignant salivary gland tumors and may create problems in the differential diagnosis [1,2]. On the other hand, different types of malignant salivary gland tumors may arise from a PA [3,4]. These malignant tumors are usually high-grade and show invasive growth [4].…”

“…On the other hand, different types of malignant salivary gland tumors may arise from a PA [3,4]. These malignant tumors are usually high-grade and show invasive growth [4]. De nitive diagnosis is important in terms of the type of treatment and patient management.…”

Carcinoma Ex Pleomorphic Adenoma in a Minor Salivary Gland of the Hard Palate: Report of a Case

“…Most CEPAs occur in the parotid gland (2)(3)(4)6). The risk of malignant transformation can appear highly in either long-standing or recurrent pleomorphic adenomas (1,3,5,7). It is extremely rare in young patients.…”