Mucoadhesive microparticles for local treatment of gastrointestinal diseases

Preisig, Daniel; Roth, Raphael; Tognola, Sandy; Varum, Felipe; Bravo, Roberto; Cetinkaya, Yalcin; Huwyler, Jörg

doi:10.1016/j.ejpb.2016.06.009

Cited by 21 publications

(10 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Optimized NPs had high drug load and good particle retention on porcine mucosa. Dry coating of the chitosan-coated microparticles with hydrophilic fumed silica improved their dispersibility, as indicated by visual observation and dissolution studies [ 129 ].…”

Section: Nanosystems As Antimicrobial Treatments Of Infectionsmentioning

confidence: 99%

Nanobiosystems for Antimicrobial Drug-Resistant Infections

et al. 2021

View full text Add to dashboard Cite

The worldwide increased bacterial resistance toward antimicrobial therapeutics has led investigators to search for new therapeutic options. Some of the options currently exploited to treat drug-resistant infections include drug-associated nanosystems. Additionally, the use of bacteriophages alone or in combination with drugs has been recently revisited; some studies utilizing nanosystems for bacteriophage delivery have been already reported. In this review article, we focus on nine pathogens that are the leading antimicrobial drug-resistant organisms, causing difficult-to-treat infections. For each organism, the bacteriophages and nanosystems developed or used in the last 20 years as potential treatments of pathogen-related infections are discussed. Summarizing conclusions and future perspectives related with the potential of such nano-antimicrobials for the treatment of persistent infections are finally highlighted.

show abstract

Section: Nanosystems As Antimicrobial Treatments Of Infectionsmentioning

confidence: 99%

Nanobiosystems for Antimicrobial Drug-Resistant Infections

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The intra-particulate pore sizes range from 500 nm to less than 100 nm and the pores can be loaded with different materials [ 37 ]. We have harnessed the capabilities of the internal porosity of FCC particles to hold small molecular compounds [ 38 , 39 ] and peptides [ 35 ]. Drug loading into FCC particles allows for convenient handling and processing of compounds that would otherwise be challenging to formulate as conventional oral dosage forms.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery

et al. 2020

Self Cite

View full text Add to dashboard Cite

Despite the wide-spread use of liposomal drug delivery systems, application of these systems for oral purposes is limited due to their large-scale formulation and storage issues. Proliposomes are one of the formulation approaches for achieving solid powders that readily form liposomes upon hydration. In this work, we investigated a dry powder formulation of a model low-soluble drug with phospholipids loaded in porous functionalized calcium carbonate microparticles. We characterized the liposome formation under conditions that mimic the different gastrointestinal stages and studied the factors that influence the dissolution rate of the model drug. The liposomes that formed upon direct contact with the simulated gastric environment had a capacity to directly encapsulate 25% of the drug in situ. The emerged liposomes allowed complete dissolution of the drug within 15 min. We identified a negative correlation between the phospholipid content and the rate of water uptake. This correlation corroborated the results obtained for the rate of dissolution and liposome encapsulation efficiency. This approach allows for the development of solid proliposomal dosage formulations, which can be scaled up with regular processes.

show abstract

“…Microparticles can be used to deliver drugs to the site of action, for either systemic uptake or local treatment. Close contact between the microparticle and the site of action can be achieved by mucoadhesion and additionally, drug release can be modulated [2,3,4]. In contrast to nanoparticles, microparticles can be used for the production of solid dosage forms [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Methods to load porous carriers with drugs include adsorption (e.g., fluidized bed processing), soaking, and solvent evaporation methods [2,17,18]. However, these methods often lead to deposition of substances on the surface of the carrier.…”

Section: Introductionmentioning

confidence: 99%

“…It is a co-precipitate from calcium carbonate and calcium phosphate which are, depending on the type, mixed at different ratios ranging from 13 to 85% ( w / w ) calcium phosphate content and a porosity of approximately 60% ( v / v ) [25]. Exploring this new excipient led to several innovative drug delivery devices such as orally disintegrating or floating tablets [26,27,28], mucoadhesive delivery systems for colon targeting [2], delivery of proteins, and loading of various small molecule drugs [17,18]. For the mentioned applications [2,17,18,26,27,28,29], we have identified a major problem with drug loading into deep porous regions of investigated microparticles as well as the understanding of the internal structure.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Loading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry

et al. 2019

Self Cite

View full text Add to dashboard Cite

Accurate analysis of intraparticle distribution of substances within porous drug carriers is important to optimize loading and subsequent processing. Mercury intrusion porosimetry, a common technique used for characterization of porous materials, assumes cylindrical pore geometry, which may lead to misinterpretation. Therefore, imaging techniques such as focused ion beam scanning electron microscopy (FIB-SEM) help to better interpret these results. The purpose of this study was to investigate the differences between mercury intrusion and scanning electron microscopy and to identify the limitations of each method. Porous microparticles, functionalized calcium carbonate, were loaded with bovine serum albumin and dipalmitoylphosphatidylcholine (DPPC) by solvent evaporation and results of the pore size distribution obtained by both methods were compared. The internal structure of the novel pharmaceutical excipient, functionalized calcium carbonate, was revealed for the first time. Our results demonstrated that image analysis provides a closer representation of the material distribution since it was possible to discriminate between blocked and filled pores. The physical nature of the loaded substances is critical for the deposition within the pores of functionalized calcium carbonate. We conclude, that a combination of mercury intrusion porosimetry and focused ion beam scanning electron microscopy allows for a reliable analysis of sub-micron porous structures of particulate drug carriers.

show abstract

Mucoadhesive microparticles for local treatment of gastrointestinal diseases

Cited by 21 publications

References 34 publications

Nanobiosystems for Antimicrobial Drug-Resistant Infections

Nanobiosystems for Antimicrobial Drug-Resistant Infections

Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery

Loading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry

Contact Info

Product

Resources

About