Mucoadhesive buccal tablets with propranolol hydrochloride: Formulation development and in vivo performances in experimental essential hypertension

Kurćubić, Ivana; Vajic, Una-Jovana; Cvijić, Sandra; Crevar-Sakač, Milkica; Bogavac-Stanojević, Nataša; Miloradović, Zoran; Mihajlović-Stanojević, Nevena; Ivanov, Milan; Karanovic, Danijela; Jovović, Djurdjica; Djuriš, Jelena

doi:10.1016/j.ijpharm.2021.121266

Cited by 7 publications

(6 citation statements)

References 24 publications

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“…Buccal films can be developed as immediate-release (IR) or prolonged-release (PR) formulations. Buccal films can also be used for local diseases of the oral cavity [16] as part of a preventive and specific treatment strategy for gingivitis [17] and periodontitis [18] or to obtain systemic therapeutic effect [19][20][21]. These films should have the appropriate size and thickness to be used on the buccal mucosa [15].…”

Section: Introductionmentioning

confidence: 99%

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3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction

et al. 2021

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Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was to evaluate the effects of the synthetic polymers PVP and PVA on thermal and mechanical properties and drug release profiles of gelatin-based films. The Fourier-transform infrared spectroscopy showed that hydrogen bonding between gelatin and PVP formed during printing. In the other blend, neither the esterification of PVA nor gelatin occurred. Differential scanning calorimetry revealed the presence of partial helical structures. In line with these results, the mechanical properties and drug release profiles were different for each blend. Formulation with gelatin-PVP and PRH showed higher tensile strength, hardness, and adhesive strength but slower drug release than formulation with gelatin-PVA and PRH. The in silico population simulations indicated increased drug bioavailability and decreased inter-individual variations in the resulting pharmacokinetic profiles compared to immediate-release tablets. Moreover, the simulation results suggested that reduced PRH daily dosing can be achieved with prolonged-release buccal films, which improves patient compliance.

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Section: Introductionmentioning

confidence: 99%

“…Propranolol hydrochloride (PRH), a model drug used in this study, is a non-selective β-adrenergic blocker. It has been used in the therapy of cardiovascular diseases such as hypertension [21], arrhythmias [23], and many others. It can also be used to treat anxiety [24], migraine [19], and tremor [25].…”

Section: Introductionmentioning

confidence: 99%

3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction

et al. 2021

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“…the quantity of bioactive ingredient. Liquid formulations may also facilitate a faster onset of action since the bioactive ingredients are readily available in Orally disintegrating dosage solid forms (films and tablets) are of special interest, due to their acceptance in a wide range of populations, including children, elderly and other patients that may have issues with swallowing; Mucoadhesive dosage forms provide a more intimate contact with the oral mucosa and often a prolonged release of the active ingredient (Kurćubić et al, 2021). Abruzzo et al (2020) have formulated mucoadhesive buccal films for the local release and anti-inflammatory action of Lactobacillus brevis CD2.…”

Section: Formulation Of Probiotics and Postbiotics In Dosage Forms Fo...mentioning

confidence: 99%

Intraoral administration of probiotics and postbiotics: An overview of microorganisms and formulation strategies

Bogdanović,

Mladenović,

Mojović

et al. 2024

Braz. J. Pharm. Sci.

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The last decade provided significant advances in the understanding of microbiota and its role in human health. Probiotics are live microorganisms with proven benefits for the host and were mostly studied in the context of gut health, but they can also confer significant benefits for oral health, mainly in the treatment of gingivitis. Postbiotics are cell-free extracts and metabolites of microorganisms which can provide additional preventive and therapeutic value for human health. This opens opportunities for new preventive or therapeutic formulations for oral administration. The microorganisms that colonize the oral cavity, their role in oral health and disease, as well as the probiotics and postbiotics which could have beneficial effects in this complex environment were discussed. The aim of this study was to review, analyse and discuss novel probiotic and postbiotic formulations intended for oral administration that could be of great preventive and therapeutic importance. A special attention has been put on the formulation of the pharmaceutical dosage forms that are expected to provide new benefits for the patients and technological advantages relevant for industry. An adequate dosage form could significantly enhance the efficiency of these products.

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“…19 Similarly, zein and PEO are polymers thoroughly explored for electrospinning and mucoadhesive applications. 20,21 Zein is a prolamin protein extracted from corn. 22 PEO is a synthetic polymer with hydroxyl functional groups.…”

Section: Introductionmentioning

confidence: 99%

Design and evaluation of propranolol hydrochloride loaded thiolated Zein/PEO electrospun fibrous matrix for transmucosal drug delivery

Surendranath¹,

Rekha²,

Nair³

et al. 2023

J. Mater. Chem. B

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Mucoadhesive buccal tablets with propranolol hydrochloride: Formulation development and in vivo performances in experimental essential hypertension

Cited by 7 publications

References 24 publications

3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction

3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction

Intraoral administration of probiotics and postbiotics: An overview of microorganisms and formulation strategies

Design and evaluation of propranolol hydrochloride loaded thiolated Zein/PEO electrospun fibrous matrix for transmucosal drug delivery

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