3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction

Jovanović, Marija; Petrović, Miloš; Cvijić, Sandra; Tomić, Nataša Z.; Stojanović, Dušica; Ibrić, Svetlana; Uskoković, Petar S.

doi:10.3390/pharmaceutics13122143

Cited by 28 publications

(26 citation statements)

References 72 publications

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“…Convolution was performed using the convolve function in R software (version 1.2.5042) ( Appendix A : R script). The buccal bioavailability was assumed to be 100%, based on the high bioavailability of other lipophilic compounds for this route [ 34 ].…”

Section: Methodsmentioning

confidence: 99%

Mucoadhesive Buccal Film of Estradiol for Hormonal Replacement Therapy: Development and In-Vivo Performance Prediction

et al. 2022

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The age-related loss of circulating estrogen that occurs during the menopausal transition manifests itself through a variety of symptoms including vasomotor (hot flushes and night sweats), genito-urinary syndrome (vaginal dryness and urinary symptoms), sexual dysfunction, mood, and sleep disturbance that often last longer than a decade. Furthermore, reductions in estrogen level increase the risks of chronic complications such as osteoporosis, cardiovascular disease, and cognitive decline among others, thereby affecting the quality of life of women. Although oral estrogens are the most widely used therapy for menopausal symptoms, they suffer from poor bioavailability, and there are concerns over their safety, creating a significant concern to consumers. Mucoadhesive buccal films are an innovative dosage form that offers several advantages including avoidance of the first-pass metabolism, fast onset of action, and importantly, improved patient acceptance. In the current work, we developed mucoadhesive estradiol film for hormonal replacement therapy using film-forming polymers. Two approaches, namely, co-solvency and nano-emulsion were evaluated to increase solubility and hence incorporate estradiol, a poorly water-soluble drug, into a formulation made from the hydrophilic polymer/s. The films were characterised for their mechanical and physicochemical properties. In-vitro release study showed that about 80% of the drug was released within 6 min from films prepared by the nano-emulsion approach, whereas it took about 10.5 min to get similar drug release from films prepared by the co-solvency approach. The ex-vivo permeation result indicates that about 15% of the drug permeated across the porcine buccal mucosa in the first 10 h from films prepared by the nano-emulsion approach, while permeation across porcine buccal mucosa was only observed at around 24 h from films prepared by the co-solvency method. The nano-emulsion films were evaluated for in vivo performance using a convolution technique using R software. The predicted Cmax and Tmax were found to be 740.74 ng mL−1 and 7 min, respectively, which were higher than previously reported in vivo concentration from oral tablets. The results demonstrated that mucoadhesive film of estradiol based on the nano-emulsion approach could be a promising platform for the delivery of estradiol through the buccal mucosa for the treatment of menopausal symptoms.

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Section: Methodsmentioning

confidence: 99%

Mucoadhesive Buccal Film of Estradiol for Hormonal Replacement Therapy: Development and In-Vivo Performance Prediction

et al. 2022

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“…Gelatin and gelatin-PVP solutions with glycerol were prepared for 3D printing, as in our previous research (5). 5% w/w ibuprofen was added to the polymer solutions for the drug-loaded scaffolds and mixed on a magnetic stirrer for 2 hours at 50 °C to obtain a clear solution.…”

Section: Semi-solid Extrusion 3d Printing Of Scaffoldsmentioning

confidence: 99%

“…5% w/w ibuprofen was added to the polymer solutions for the drug-loaded scaffolds and mixed on a magnetic stirrer for 2 hours at 50 °C to obtain a clear solution. After that, the syringes filled with mixtures were left for gelation at 36 °C for 12 hours to obtain good printability (smooth surface and good appearance of extruded filaments) (5,24). The scaffolds were printed using a FDM 3D printer modified with a semi-solid extruder at 32 °C (Figure 1) (5).…”

Section: Semi-solid Extrusion 3d Printing Of Scaffoldsmentioning

confidence: 99%

“…The morphology and microstructure of printed scaffolds were analysed by FESEM TESCAN MIRA 3 (Tescan Orsay Holding, a.s., Brno-Kohoutovice, Czech Republic) (5,25).…”

Section: Field Emission Scanning Electron Microscope (Fesem)mentioning

confidence: 99%

“…SSE 3D printing uses paste/gel as feedstock material that is extruded through the print nozzle. The benefit of SSE is that it employs low temperature, commonly used solvents, and excipients such as polymers, plasticizers or inorganic/organic reinforcements mixed with API to prepare paste/gel (5,6).…”

Section: Introductionmentioning

confidence: 99%

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Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery

Jovanović¹,

Petrović²,

Stojanović³

et al. 2022

Arhiv za farmaciju

Self Cite

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In this work, a blend of gelatin A (GA) and polyvinylpyrrolidone (PVP K30) was used for semi-solid 3D printing of bone scaffold for ibuprofen (IBU) delivery. The cross-linking of the obtained scaffold was performed with a 1% glutaraldehyde (GTA) solution, followed by lyophilization. The thermal and mechanical properties, as well as drug release profiles, and drug kinetics of prepared scaffolds were investigated. The cross-linked and lyophilized scaffold has shown good thermal stability, mechanical properties, and prolonged release of IBU following the Fickian diffusion process.

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Hot-Melt Extrusion Paired Fused Deposition Modeling 3D Printing: Development of Pharmaceutical Medications

Nyavanandi,

Narala,

Repka

2023

3D Printing

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3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction

Cited by 28 publications

References 72 publications

Mucoadhesive Buccal Film of Estradiol for Hormonal Replacement Therapy: Development and In-Vivo Performance Prediction

Mucoadhesive Buccal Film of Estradiol for Hormonal Replacement Therapy: Development and In-Vivo Performance Prediction

Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery

Hot-Melt Extrusion Paired Fused Deposition Modeling 3D Printing: Development of Pharmaceutical Medications

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