Mucoadhesive Buccal Drug Delivery System: Review Article

Sonawane, Monali; Shinkar, Dattatrey; Ravindrasaudagar,

doi:10.22159/ijcpr.2017v9i4.20960

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…It helps in enhancing the bioavailability through bypassing the first-pass metabolism effect, the mucosal surface better absorption, and prolonged resident time. Among the various transmucosal sites available, mucosa of the buccal cavity was found to be the most convenient and easily approachable site for the delivery of the therapeutic agent for both local and systemic deliveries [8].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Effect of Different Grades and Concentrations of Ph‑sensitive Polymer on Preparation and Characterization of Lidocaine Hydrochloride as in Situ Gel Buccal Spray

Sulaiman

Jabir

Al-Kinani

2018

Asian J Pharm Clin Res

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Objective: The present study was aimed to develop a pH-triggered in situ gel for local release of lidocaine hydrochloride (lidocaine HCL) in the buccal cavity to improve the anesthetic effect of this amino amide drug which has very high water solubility. The formulations were introduced to the oral cavity as a spray to improve compliance and for easier administration.Methods: In this work, two grades of carbopol (934 and 940)-based in situ gel spray were designed. The formulations containing lidocaine HCl 5% were prepared by mixing different concentrations of carbopol with xanthan gum. Eight formulations were investigated and evaluated for gelation capacity, spray angle, volume of solution delivered per each actuation, rheological properties, and release kinetic model. Similarity factor (f2) was used for the comparison of dissolution profiles.Results: The prepared formulations undergo gelation after it had been actuated to the buccal cavity as a spray solution. The results showed that, as the concentration of polymer was increased, the release of drug decreased and the viscosity increased for both grades. The spray angle and volume of solution delivered per each actuation varied according to the composition of each formulation. The in situ gel containing 0.3% carbopol 934 and 0.2% xanthan gum regarded as a better candidate which had a good gelation and release property compared to other formulations. Drug release from optimized in situ gel spray followed Korsmeyer–Peppas model and was mediated by Fickian diffusion mechanism.Conclusion: Lidocaine HCl-loaded pH-sensitive in situ gel was successfully developed using carbopol 934 as polymer to be applied to the buccal cavity as spray solution for more effective anesthetic effect and painless treatment.

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Section: Introductionmentioning

confidence: 99%

Investigating the Effect of Different Grades and Concentrations of Ph‑sensitive Polymer on Preparation and Characterization of Lidocaine Hydrochloride as in Situ Gel Buccal Spray

Sulaiman

Jabir

Al-Kinani

2018

Asian J Pharm Clin Res

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“…Suitable bioadhesive buccal patches with desired permeability buccal delivery show good absorption and bioavailability compared to the oral solution. Buccal patches and ilms of sustainedrelease drugs bypass the extensive hepatic irstpass metabolism along with increased bioavailability (Sonawane et al, 2017).…”

Section: Buccal Delivery Systemmentioning

confidence: 99%

An analytical assessment on Mucoadhesive Buccal Drug Delivery System for improving patient convenience and compliance

Amarendra

Subha

et al. 2020

ijrps

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In recent years, the novel mucoadhesive buccal drug delivery system has been developed over the conventional and systemic dosage forms. To bypass drugs from the hepatic first-pass metabolism and it enhances the bioavailability of drug at the site of administration. Absorption of a drug through the buccal mucosa reduces the degradation. Some of the enzyme activity and pH variation in the gastrointestinal tract reduces the absorption and active drug loss. To overcome this problem, the buccal route is preferred. Polymers are used in this formulation to improve the drug release rate over an extended period, and also, the therapeutic plasma level of the drug can be rapidly achieved. Overall this narrative review explains mechanism and theories, method of preparation, factors affecting mucoadhesion, advantages and limitations, applications, components used in the formulation, characterization and evaluation methods. Since the cytoplasm and intercellular spaces are hydrophilic. Lipophilic drugs have a low solubility in this environment. However, the cell membrane is rather lipophilic; it tends to difficulty permeating the hydrophilic solute through the cell membrane because of a low partition coefficient. Therefore, the cytoplasm and intercellular spaces act as a major barrier to penetration of lipophilic compounds and the cell membrane poses as an extensive transport barrier for hydrophilic compounds. Since the oral epithelial is stratified, the permeation of solute may involve these combination routes so that the route is more predictable.

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“…These cross linking agents have various important properties which are required for muco-adhesion like easy wetting, better mutual adsorption and better penetration and interpenetration ability within the polymer and the oral mucus. These muco-adhesive polymers which have ability to bind with the mucus present on the epithelial cells surfaces can further be divided into three classes [11][12][13].…”

Section: Muco-adhesive Polymersmentioning

confidence: 99%

Overview of Mucoadhesive Biopolymers for Buccal Drug Delivery Systems

et al. 2019

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Mucoadhesive dosage forms may be intended for facilitation of prolonged retention time at the application site hence providing drug release in a controlled rate for enhanced improvement of therapeutic activity and its outcome. The buccal mucosa has been investigated for systemic drug delivery and local drug treatment or therapy that is subjected to first pass metabolism. The applicability of bio-adhesion approach in buccal drug delivery proved great therapeutic potential to overcome the limitation of conventional buccal drug delivery. The delivery via buccal route using mucoadhesive biopolymers such as various natural gums e.g. carrageenans, gum karaya, gum arabic, locust bean gum, khaya gum, gum ghatti, albizia gum, guar gum, starch, cellulose, larch gum and pectin etc. and various thiolated and carboxymethylated polymers has been the subject of interest since the early 20th century. The present article is focused mainly on the oral mucosa, mechanism of drug permeation, and characteristics of the desired polymers, the manuscript then proceeds to cover the theories behind the adhesion of bioadhesive polymers to the mucosal epithelium followed by the factors affecting mucoadhesion. Further the author has also discussed on the new generation of mucoadhesive polymers and their properties, recent mucoadhesive formulations for enhanced buccal drug delivery, various marketed products and patent literature. Various online search engines and scientific journals were employed for the collection of literature and scientific data and information related to the topic using keywords like mucoadhesive polymers, buccal drug delivery, buccal patches, tablets, films, gels, powder from the year 2002 and above.

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Mucoadhesive Buccal Drug Delivery System: Review Article

Cited by 6 publications

References 5 publications

Investigating the Effect of Different Grades and Concentrations of Ph‑sensitive Polymer on Preparation and Characterization of Lidocaine Hydrochloride as in Situ Gel Buccal Spray

Investigating the Effect of Different Grades and Concentrations of Ph‑sensitive Polymer on Preparation and Characterization of Lidocaine Hydrochloride as in Situ Gel Buccal Spray

An analytical assessment on Mucoadhesive Buccal Drug Delivery System for improving patient convenience and compliance

Overview of Mucoadhesive Biopolymers for Buccal Drug Delivery Systems

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