Mucoadhesion evaluation of polysaccharide gels for vaginal application by using rheological and indentation measurements

Pliszczak, D.; Bordes, Claire; Bourgeois, Sandrine; Marote, Pedro; Zahouani, H.; Tupin, Simon; Mattei, Christophe; Lantéri, Pierre

doi:10.1016/j.colsurfb.2011.11.039

Cited by 20 publications

(6 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chemical Structure of CLO residence time, maximum detachment force and work of adhesion in the presence of porcine vaginal mucosa were examined. Regarding the fact that mucoadhesive properties can be determined using different experimental conditions, [16][17][18] the objective of this study was also to investigate the usefulness of two different mucosa surrogates as simple adhesive models imitating vaginal mucosa-gelatin rings and mucin gel.…”

Section: -7)mentioning

confidence: 99%

Vaginal Chitosan Tablets with Clotrimazole—Design and Evaluation of Mucoadhesive Properties Using Porcine Vaginal Mucosa, Mucin and Gelatine

et al. 2014

View full text Add to dashboard Cite

Topical administration of clotrimazole represents the common use therapy in the antimycotic genitourinary tract treatment. Due to the fast self-cleaning action of the vagina, commercially available vaginal dosage forms with clotrimazole cannot assure prolonged contact time with mucosa, therefore the main objective of this study was to develop a dosage form for vaginal administration of clotrimazole using chitosan-a biodegradable and biocompatible derivative of chitin. Tablets mucoadhesive properties were examined using texture analyser under the presence of porcine vaginal mucosa and two different models of adhesive layersmucin gel and gelatine discs. In addition, friability, hardness, swelling behaviour, residence time, surface morphology of the performed tablets, the in vitro release profile of clotrimazole and clotrimazole release kinetics were determined. The release of clotrimazole from formulations with 25 or 40% of chitosan (F2 and F3) followed non Fickian diffusion through chitosan-gel layer and was retarded up to 6 h. Additionally, tablets F2 showed the best results in terms of mucoadhesive properties and appeared to be a good alternative to commercially available antimycotic vaginal dosage forms.

show abstract

Section: -7)mentioning

confidence: 99%

Vaginal Chitosan Tablets with Clotrimazole—Design and Evaluation of Mucoadhesive Properties Using Porcine Vaginal Mucosa, Mucin and Gelatine

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The mean values of the storage modulus for each sample were taken from the frequency sweep spectra. The absolute synergism parameter (△ G `) is a storage modulus component showing the interactions among polymers and mucins [ 31 ]. The following equation was used to calculate △ G ` [ 32 ]: where G ’ mix , G ’ p , and G ’ m are the storage moduli of the mixture, polymers, and mucin, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…The following equation was used to calculate △ G ` [ 32 ]: where G ’ mix , G ’ p , and G ’ m are the storage moduli of the mixture, polymers, and mucin, respectively. The elastic modulus of the mucin solution can be removed from the equation since the elastic modulus of the mucin dispersion was negligible [ 30 , 31 ]. Therefore, △ G ` was determined from the following equation: …”

Section: Methodsmentioning

confidence: 99%

Synthesis and characterization of thiolated hexanoyl glycol chitosan as a mucoadhesive thermogelling polymer

Cho

et al. 2018

Biomater Res

View full text Add to dashboard Cite

BackgroundMucoadhesive polymers, which may increase the contact time between the polymer and the tissue, have been widely investigated for pharmaceutical formulations. In this study, we developed a new polysaccharide-based mucoadhesive polymer with thermogelling properties.MethodsHexanoyl glycol chitosan (HGC), a new thermogelling polymer, was synthesized by the chemical modification of glycol chitosan using hexanoic anhydride. The HGC was further modified to include thiol groups to improve the mucoadhesive property of thermogelling HGC. The degree of thiolation of the thiolated HGCs (SH-HGCs) was controlled in the range of 5–10% by adjusting the feed molar ratio. The structure of the chemically modified polymers was characterized by 1H NMR and ATR-FTIR. The sol-gel transition, mucoadhesiveness, and biocompatibility of the polymers were determined by a tube inverting method, rheological measurements, and in vitro cytotoxicity tests, respectively.ResultsThe aqueous solution (4 wt%) of HGC with approximately 33% substitution showed a sol-gel transition temperature of approximately 41 °C. SH-HGCs demonstrated lower sol-gel transition temperatures (34 ± 1 and 31 ± 1 °С) compared to that of HGC due to the introduction of thiol groups. Rheological studies of aqueous mixture solutions of SH-HGCs and mucin showed that SH-HGCs had stronger mucoadhesiveness than HGC due to the interaction between the thiol groups of SH-HGCs and mucin. Additionally, we confirmed that the thermogelling properties might improve the mucoadhesive force of polymers. Several in vitro cytotoxicity tests showed that SH-HGCs showed little toxicity at concentrations of 0.1–1.0 wt%, indicating good biocompatibility of the polymers.ConclusionsThe resultant thiolated hexanoyl glycol chitosans may play a crucial role in mucoadhesive applications in biomedical areas.

show abstract

“…Several natural and synthetic polymers appear to be mucoadhesive due to the instauration establishment of Van der Waals forces, hydrogen bonds and dipole-dipole interactions with mucin (Khutoryanskiy, 2011). Among these, hyaluronic acid (HA), a safe and biocompatible polysaccharide with excellent gelling and lubricant properties, showed promising results as mucoadhesive excipient for ocular, nasal and vaginal delivery (Luppi et al, 2009;Pliszczak et al, 2012;Zheng, Goto & Ohashi, 2014). By means of thiolation its mucoadhesive properties could be improved and thiolated HA has been studied as excipient for buccal patches, vaginal tablets, ocular inserts, hydrogels for wound healing and scaffold for tissue engineering (Eng, Caplan, Preul & Panitch, 2010;Laffleur & Dachs, 2015;Laffleur, Wagner & Barthelmes, 2015;Nowak, Laffleur & Bernkop-Schnurch, 2015; Zheng Shu, Liu, Palumbo, Luo & Prestwich, 2004).…”

Section: Introductionmentioning

confidence: 99%

Totally S-protected hyaluronic acid: Evaluation of stability and mucoadhesive properties as liquid dosage form

Sousa

Suchaoin

Zupančič

et al. 2016

Carbohydrate Polymers

View full text Add to dashboard Cite

Mucoadhesion evaluation of polysaccharide gels for vaginal application by using rheological and indentation measurements

Cited by 20 publications

References 53 publications

Vaginal Chitosan Tablets with Clotrimazole—Design and Evaluation of Mucoadhesive Properties Using Porcine Vaginal Mucosa, Mucin and Gelatine

Vaginal Chitosan Tablets with Clotrimazole—Design and Evaluation of Mucoadhesive Properties Using Porcine Vaginal Mucosa, Mucin and Gelatine

Synthesis and characterization of thiolated hexanoyl glycol chitosan as a mucoadhesive thermogelling polymer

Totally S-protected hyaluronic acid: Evaluation of stability and mucoadhesive properties as liquid dosage form

Contact Info

Product

Resources

About