Muco-epidermoid tumours of the anal canal

Morson, B C; Volkstädt, H.

doi:10.1136/jcp.16.3.200

Cited by 42 publications

(11 citation statements)

References 13 publications

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“…They have also been found in the esophagus [12], anus [13] and vagina [14] where squamous cell carcinomas predominate. In this series, the incidence of ASC of the pancreas was 2.1% (7/327), which was in the range of 0.9–3.8% in previous reports (table 3) [4,15,16,17,18].…”

Section: Discussionmentioning

confidence: 99%

Adenosquamous Carcinoma of the Pancreas

Hsu¹,

Yeh²,

Chen

et al. 2005

Digestion

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Background/Aims: Adenosquamous carcinoma (ASC) of the pancreas is rare and correct preoperative diagnosis is difficult. Case reports of ASC of the pancreas are sporadic and have typically employed small series. This study investigated the clinicopathological features of 7 cases of ASC of the pancreas and reviewed the pertinent literature to elucidate this rare disease. Methodology: Seven patients (4 men and 3 women; age range 38–79 years; median 66 years) with ASC of the pancreas who underwent surgical treatment at Chang Gung Memorial Hospital between February 1993 and April 2000 were retrospectively reviewed. Results: Symptoms of ASC were as follows: abdominal pain (85.7%), body weight loss (85.7%), jaundice (42.9%) and anorexia (42.9%). The tumors were located at the head of the pancreas in 4 patients (57.1%), at the body in 2, and at the tail in 2. One patient had ASC at the body and tail. Most cases (5/7, 71.4%) were anemic. Seven (100%) and 5 patients (71.4%) had elevated serum CEA and CA19-9 levels, respectively. Curative pancreaticoduodenectomy was performed on 2 patients, bypass surgery on 3, and exploratory laparotomy on 2. Two patients underwent intraoperative radiotherapy. Three patients received postoperative adjuvant chemotherapy. No surgical mortality or morbidity occurred. Five of 7 patients (71.4%) died within 6 months after surgery. The median survival of the 7 patients was 4.41 months (range 1.12–22.42). Conclusions: Patients with ASC present symptoms similar to those of adenocarcinoma of the pancreas. Most patients had dismal prognosis despite aggressive surgery with or without adjuvant therapy.

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Section: Discussionmentioning

confidence: 99%

Adenosquamous Carcinoma of the Pancreas

Hsu¹,

Yeh²,

Chen

et al. 2005

Digestion

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“…Kay 2 examined this disease in 1954, and a total of 56 cases have been reported to date. [1][2][3][4][5][6] Table 2 shows a summary of the characteristics of these reported cases. The histogenesis of mucoepidermoid carcinoma of the anus has been discussed.…”

Section: Discussionmentioning

confidence: 97%

“…Only 56 cases have been reported previously. [1][2][3][4][5][6] The origin of this tumor has been debated, tumor was composed of goblet-cell-type mucous cells and the solid sheets. The mucous cells were seen sporadically, and the solid sheets consisted of large nonkeratinizing or spindle-shaped cells.…”

Section: Introductionmentioning

confidence: 99%

Mucoepidermoid carcinoma of the anal canal: an immunohistochemical study

Hanamura¹,

Kobayashi²,

Seki³

et al. 2001

Journal of Gastroenterology

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We present a case of mucoepidermoid carcinoma of the anal canal, with special reference to immunohistochemical analysis of the tumor to clarify its histogenesis. A 36-year-old man underwent surgery for mucoepidermoid carcinoma of the anal canal. Immunohistochemical analysis of the resected specimen was performed. Serial sections were stained immunohistochemically by the labeled streptavidin-biotin peroxidase method for various antigens, including epithelial membrane antigen (EMA); carcinoembryonic antigen (CEA); different types of cytokeratins, including CK10 and CAM 5.2; and p53 oncoprotein. The solid component of the tumor cells was immunohistochemically positive for EMA, CEA, and CAM 5.2, but negative for CK10. These staining patterns were different from those of anal squamous epithelium. These results confirm that mucoepidermoid carcinoma of the anus may arise from the anal transitional zone, and that it is biologically different from squamous cell carcinoma of the anus.

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“…Morson ( 15) states that basaloid, mucoepidermoid and some ordinary squamous carcinomas arise in the ATZ. This concept is based on studies on the location of anal canal tumours, many of which were mainly located above the dentate line (14,17,20). Other evidence for this concept would be the demonstration of precancerous changes located to the ATZ in association with such tumours.…”

Section: Discussionmentioning

confidence: 99%

Precancerous Changes in the Anal Canal Epithelium in Resection Specimens

Fenger

Nielsen

1986

Acta Pathologica Microbiologica Scandinavica Series A :Patholog

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Fenger, C. & Nielsen, V. T. Precancerous changes in the anal canal epithelium in resection specimens. Acta path. microbiol. immunol. scand. Sect. A, 94: 63-69, 1986. Systematic histological examination for precancerous changes was carried out on 139 anal canals resected for anal or colo-rectal tumours or for inflammatory bowel disease. Severe squamous dysplasia or carcinoma in situ were found in 13 of 16 anal canals harbouring variants of squamous carcinoma but not in others. The lesions were mainly or totally located to the anal transitional zone (ATZ) in 11 cases and only in 2 cases exclusively to the squamous zone below the dentate line. Dysplastic areas separate from the tumour were found in 6 of the 13 cases. Junctional melanocytic activity and atypical melanocytic hyperplasia located in the ATZ as well as the squamous zone were present in I of 3 cases of malignant melanoma. The findings underline the close relationship between dysplasia and invasive carcinoma in the anal canal. Further they support the concept that basaloid, mucoepidermoid and some ordinary squamous carcinomas arise in the ATZ, and that this may also be the point of origin for malignant melanoma. A search for precancerous changes for anal canal tumours should therefore include the whole ATZ, i.e. in some cases up to 2 cm above the dentate line and it should be borne in mind that the lesions may be spotty.

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Muco-epidermoid tumours of the anal canal

Cited by 42 publications

References 13 publications

Adenosquamous Carcinoma of the Pancreas

Adenosquamous Carcinoma of the Pancreas

Mucoepidermoid carcinoma of the anal canal: an immunohistochemical study

Precancerous Changes in the Anal Canal Epithelium in Resection Specimens

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