Mucoepidermoid carcinoma of the anal canal: an immunohistochemical study

Hanamura, Naoshi; Kobayashi, Mitsuo; Seki, Tatsuhiko; Adachi, Wataru

doi:10.1007/s005350170077

Cited by 12 publications

(9 citation statements)

References 15 publications

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“…1 Similar observations were documented by others later. 4,5 The World Health Organization classification 6 has recommended against histologic subtyping of anal SCC though, because of the frequent admixture of histologic patterns, poor reproducibility, and a lack of clinical significance as described by Fenger et al 7 Instead, it is recommended to report on whether the carcinoma is keratinizing or nonkeratinizing, with a descriptive comment on adverse prognostic features. Nevertheless, the few data on the histologic variation in basaloid SCC and the deemphasis of histologic subtypes may contribute to misdiagnosis of basaloid SCC or its mimics.…”

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confidence: 98%

Basaloid Squamous Cell Carcinoma of the Anus Revisited

Graham

Arnold

Naini

et al. 2016

American Journal of Surgical Pathology

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Basaloid squamous cell carcinoma (SCC) of the anus, previously called cloacogenic carcinoma, is a subtype of SCC. There are very few data on the morphologic variation within basaloid SCC of the anus, which may contribute to misdiagnosis. We retrospectively evaluated cases originally diagnosed as basaloid SCC for histologic characterization. We retrieved and reviewed cases of basaloid SCC from 1994 to 2013. Ten (27%) cases were reclassified after review, including basal cell carcinoma (n=6), melanoma (n=2), and neuroendocrine carcinoma (n=2). The final group of basaloid SCC (n=27) showed a female predominance (median age=60 y; range, 42 to 92 y). Morphologically, basaloid SCC could be categorized into 4 groups: transitional carcinoma like (n=10), basaloid with peripheral palisade (n=13), adenoid cystic carcinoma like (n=3), and mucinous microcystic (n=1). In 19 cases the histologic patterns were pure and were mixed in the remainder. CK5/6, p16, and high-risk HPV were positive in all cases (n=27). SOX2 was positive in 18/22 cases. Clinical follow-up was available on 60% of cases; 9 patients (53%) developed local recurrence or metastasis, and 5 (29%) died of disease. Basaloid SCC of the anus is characterized by 4 major histologic patterns and is consistently HPV driven.

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confidence: 98%

Basaloid Squamous Cell Carcinoma of the Anus Revisited

Graham

Arnold

Naini

et al. 2016

American Journal of Surgical Pathology

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“…In general, salivary mucoepidermoid carcinoma is a slow growing tumor, and its prognosis is better than that of ordinal adeno‐ or squamous cell carcinoma (SCC) 1–3 . However, it has also been reported that the poorly differentiated type, although not frequent, is highly malignant and often metastasized to regional lymph nodes and other organs 1–9 . In this report we detail a case of primary hepatic mucoepidermoid carcinoma with highly aggressive progression and early mortality.…”

Section: Introductionmentioning

confidence: 92%

“…Although mucoepidermoid carcinoma is sometimes seen as a neoplasm originating from the salivary glands, it is rarely seen originating from other organs, including oral mucosa, esophagus, anal canal, skin of the breast, lachrymal sac, thymus, thyroid gland, tracheobroncial tree, lung or uterine cervix 1–9 . For primary hepatic mucoepidermoid carcinoma, only 16 cases have been reported in the English literature 10–21 .…”

Section: Introductionmentioning

confidence: 99%

“…A LTHOUGH MUCOEPIDERMOID CARCINOMA is sometimes seen as a neoplasm originating from the salivary glands, it is rarely seen originating from other organs, including oral mucosa, esophagus, anal canal, skin of the breast, lachrymal sac, thymus, thyroid gland, tracheobroncial tree, lung or uterine cervix. [1][2][3][4][5][6][7][8][9] For primary hepatic mucoepidermoid carcinoma, only 16 cases have been reported in the English literature. [10][11][12][13][14][15][16][17][18][19][20][21] Because of the limited number of cases, its etiology has not yet been elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Mucoepidermoid carcinoma of the liver: report of a rare case and review of the literature

Arakawa¹,

Shimada²,

Ikegami³

et al. 2008

Hepatology Research

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Although a mucoepidermoid carcinoma is sometimes seen as a neoplasm originating from the salivary glands, its origination from the liver is rare. A review of the medical literature in the English language disclosed only 16 cases originating from the hepatic system. The case explored here is that of an 81-year-old female, without any significant medical history, who was referred to our hospital for elevated liver function tests. Computed tomography (CT) showed a huge tumor, 10 cm in diameter, in the right lobe of the liver. The central part of the tumor was consistently un-enhanced, suggesting a large necrotic area. The liver tumor was diagnosed as mucoepidermoid carcinoma by a percutaneous biopsy. Despite chemotherapy with radiation therapy, the tumor showed very aggressive malignancy, resulting in early mortality. We herein report on a rare case of primary mucoepidermoid carcinoma of the liver with pulmonary and lymph node metastasis, confirmed by autopsy, and review the literature.

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“…It seems that the squamous component is biologically closer to adenocarcinoma than to anal squamous cell carcinomas [ 109 ].…”

Section: Squamous Cell Carcinoma With Prominent Mucinous Features (Mumentioning

confidence: 99%