Mucinous tumor arising in a giant sacrococcygeal teratoma

Abstract

Rationale:Teratomas, which most frequently affect adult females, are the most common type of germ cell tumor, it always comprises derivatives of at least 2 germ layers. The most common site of primary teratomas is the ovary. Sacrococcygeal teratomas (SCTs), which are exceedingly rare in adults, are generally found in newborns or children.Patient concerns:A 39-year-old woman presented to our clinic with a 1-year history of gradually aggravated difficulty in micturition and defecation, and a tumor in her right buttock present since birth. Appropriate preoperative examinations showed a large (15.6 cm × 12.2 cm × 30.0 cm) multicystic SCT.Diagnoses:Histologic examination confirmed a mucinous tumor arising in a giant SCT.Interventions:Abdominoperineal rectal resection was performed.Outcomes:The patient recovered well and was discharged on day 33 of admission.Lessons:We report the first case of a mucinous tumor arising in an SCT, in which the teratoma presented mature tissue elements derived only from the endodermal germ layer (keratinous debris).

Adult sacrococcygeal teratoma: A review

“…[15] The risk of malignant transformation in adult SCT ranges from 1 to 12%. [22] Malignancy of any component may occur; however, ectodermal squamous cell carcinoma is the most common component. [40] Others include basal cell carcinoma, melanoma, adenocarcinoma, sarcoma, and thyroid cancer.…”

“…[ 21 ] The CA199-positive rates in immature, mature, and malignant SCTs were 57%, 57%, and 48.6%, respectively. [ 22 ] Elevated α-fetoprotein (AFP) levels are common in yolk sac tumors, certain immature teratomas, embryonal and polyembryoma carcinomas, and mixed germ cell tumors. In adult SCT, an AFP level >250 µg/mL indicates malignancy.…”

Sacrococcygeal teratoma in an adult containing a mucinous adenocarcinoma

“…β-Human Chorionic Gonadotropin (β-HCG) and α-fetoprotein (αFP) can help differentiate between immature and mature teratomas. Malignant transformation within sacrococcygeal tumours is exceptionally rare, with only a few case reports noted 6…”

A rare case report of mucinous adenocarcinoma arising in sacrococcygeal teratoma in an adult patient and brief review

“…In our case, the mass was entirely located in presacral component with extension into subcutaneous plane, hence wide excision with overlying skin was performed. Malignant transformation in sacrococcygeal teratoma is rarely reported with only a few case reports described in the literature [6][7][8] Table 1. In all these cases, malignancy was not suspected clinically and was only detected by thorough histopathological examination similar to our case.…”