Mucinous Carcinomas of the Gallbladder: Clinicopathologic Analysis of 15 Cases Identified in 606 Carcinomas

Dursun, Nevra; Escalona, Oscar Tapia; Roa, Juan Carlos; Basturk, Olca; Bağcı, Pelin; Çakır, Aslı; Cheng, Jiqi; Sarmiento, Juan M.; Losada, Héctor; Kong, So Yeon; Ducato, Leslie; Goodman, Michael; Adsay, Volkan

doi:10.5858/arpa.2011-0447-oa

Cited by 63 publications

(74 citation statements)

References 57 publications

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“…They are typically large and advanced tumours at the time of diagnosis, with 87% of the cases showing T3 tumours, as opposed to 48% in conventional GB adenocarcinomas, and thus exhibit more-aggressive behavior than conventional GB carcinomas. 4 They may lead to pseudomyxoma peritonei. Giang et al, in a review of 23 GB carcinomas, discussed the potential pitfall of confusing primary mucinous adenocarcinoma of GB with pseudomyxoma peritonei from a low-grade appendiceal neoplasm disseminated to GB, especially when only the GB is removed.…”

Section: 3mentioning

confidence: 99%

“…Immunophenotypically, mucinous carcinomas of gall bladder differ from intestinal carcinomas by an inverse CK7/20 profile, and from pancreatic mucinous carcinomas by CDX2 negativity (Figure 4). 4 The risk factors, associated features, natural history and prognosis of mucinous carcinoma of GB are not very well known, owing to their extreme rarity. They are typically large and advanced tumours at the time of diagnosis, with 87% of the cases showing T3 tumours, as opposed to 48% in conventional GB adenocarcinomas, and thus exhibit more-aggressive behavior than conventional GB carcinomas.…”

Section: 3mentioning

confidence: 99%

“…Perineural invasion has been reported in 73% cases, however, it was not seen in the present case. 4 In the cases showing perineural invasion, nerve bundles present in mucin pools can be identified by special stains for mucin (Alcian blue, mucicarmine), as well as IHC for mucin (Muc1) and for nerve bundles (S100). Immunophenotypically, mucinous carcinomas of gall bladder differ from intestinal carcinomas by an inverse CK7/20 profile, and from pancreatic mucinous carcinomas by CDX2 negativity (Figure 4).…”

Section: 3mentioning

confidence: 99%

“…2,3 These present in middle to late age group (47 to 78 years), usually don't have a sex predilection, and clinically exhibit symptoms of acute cholecystitis. 4 Approximately twenty cases of mucinous carcinoma of the GB have been reported so far. We report a very rare case of pure mucinous carcinoma of the GB.…”

Section: Introductionmentioning

confidence: 99%

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Pure mucinous (colloid) carcinoma of gall bladder: a rare entity

Rawal¹,

Ahluwalia²,

Yadav³

et al. 2017

Int Surg J

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In the biliary tract, ‘mucinous’ carcinomas in which extracellular mucin constitutes more than 50% of the tumour volume, are very rare. Those tumours in which the mucinous pattern comprises of at least 90% of the tumour are called ‘pure mucinous’ carcinomas and are exceedingly rare in the gallbladder. We describe the case of a 55 years old female, who presented with the complaints of jaundice and dull aching pain in right hypochondriac region. USG abdomen was suggestive of carcinoma along with cholelithiasis, following which cholecystectomy was performed. Grossly, a large grey-white tumour was identified whose cut surface was variegated. Sections showed a tumour which was entirely composed of pools of extracellular mucin, in which clusters of tumour cells were floating. Based on morphology and immunohistochemistry, a final diagnosis of ‘pure mucinous (colloid) adenocarcinoma’ of the gallbladder was given. This case is described owing to the rarity of this neoplasm. The clinical features, natural history and prognosis of mucinous carcinoma of GB are not very well known, due to their extreme rarity. These have been discussed in this case report. Histopathological examination is vital for a decisive diagnosis of such cases.

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Section: 3mentioning

confidence: 99%

Section: 3mentioning

confidence: 99%

Section: 3mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pure mucinous (colloid) carcinoma of gall bladder: a rare entity

Rawal¹,

Ahluwalia²,

Yadav³

et al. 2017

Int Surg J

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show abstract

“…[4][5][6] The risk factors for all gall bladder carcinoma are gall stones, calcified porcelain gall bladder, choledochal cyst, polypoid lesion of the gall bladder, sclerosing cholangitis, anomalous pancreaticobiliary junction and exposure to carcinogens. [4][5][6] In recent analysis of 15 cases gall bladder carcinoma, 67% patients presented with clinical picture of acute cholecystitis such pain in right hypochondriac region and vomiting. 4 They observed that these tumours are generally large and advanced at the time of diagnosis, so they have more aggressive behavior than conventional adenocarcinoma of gall bladder.…”

Section: Case Reportmentioning

confidence: 99%

Mucinous adenocarcinoma of gall bladder: a case report

et al. 2017

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Gall bladder carcinoma is the fifth most common malignancy of gastrointestinal tract. Mucinous carcinoma of gall bladder is very rare variant of gall bladder carcinoma. Only 20 cases of mucinous carcinoma reported till now. We report one such case of 55yr old female patient presented to our hospital with complaining of pain in right hypochondriac region and vomiting since, one month. Radiological examination revealed neoplastic thickening of gall bladder neck with cholelithiasis. Cholecystectomy was performed and specimen showed glistening grey white infiltrative firm solid mass at the neck of gall bladder. On microscopic examination showed mucinous adenocarcinoma. Tumour comprised of cystically dilated mucin filled glands. Tumour was seen infiltrating into muscle layer.

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The molecular background of mucinous carcinoma beyond MUC2

Hugen

Simons

Halilović

et al. 2014

The Journal of Pathology CR

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The increasing interest of the oncology community in tumour classification and prediction of outcome to targeted therapies has put emphasis on an improved identification of tumour types. Colorectal mucinous adenocarcinoma (MC) is a subtype that is characterized by the presence of abundant extracellular mucin that comprises at least 50% of the tumour volume and is found in 10–15% of colorectal cancer patients. MC development is poorly understood, however, the distinct clinical and pathological presentation of MC suggests a deviant development and molecular background. In this review we identify common molecular and genetic alterations in colorectal MC. MC is characterized by a high rate of MUC2 expression. Mutation rates in the therapeutically important RAS/RAF/MAPK and PI3K/AKT pathways are significantly higher in MC compared with non‐mucinous adenocarcinoma. Furthermore, mucinous adenocarcinoma shows higher rates of microsatellite instability and is more frequently of the CpG island methylator phenotype. Although the majority of MCs arise from the large intestine, this subtype also develops in other organs, such as the stomach, pancreas, biliary tract, ovary, breast and lung. We compared findings from colorectal MC with tumour characteristics of MCs from other organs. In these organs, MCs show different mutation rates in the RAS/RAF/MAPK and PI3K/AKT pathways as well, but a common mucinous pathway cannot be identified. Identification of conditions and molecular aberrations that are associated with MC generates insight into the aetiology of this subtype and improves understanding of resistance to therapies.

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Mucinous Carcinomas of the Gallbladder: Clinicopathologic Analysis of 15 Cases Identified in 606 Carcinomas

Cited by 63 publications

References 57 publications

Pure mucinous (colloid) carcinoma of gall bladder: a rare entity

Pure mucinous (colloid) carcinoma of gall bladder: a rare entity

Mucinous adenocarcinoma of gall bladder: a case report

The molecular background of mucinous carcinoma beyond MUC2

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