Mucin, Melanin, and Glycogen in Paget's Disease of the Breast

Quiz Correct answer to the quiz. check your diagnosis Pigmented paget’s disease of the nipple

“…In the majority of these cases pigment granules were few in number and present only in isolated cells. Similarly to the previously mentioned report, in only one case did numerous cells contain abundant pigment [10]. Only in these heavily pigmented cases does clinically visible pigmentation warrant classification as PPD [4].…”

Pigmented Epidermotropic Metastasis of a Breast Carcinoma

“…This analysis requires a good deal of critical judgment, as techniques are far from being perfectly spe cific [3,4,6,12,13]; only the use of a wide range of tests ensures a correct diagnosis.…”

“…There is, sometimes, a relationship of sim ple neighbourhood, which can complicate the diagnostic interpretation, especially if pigment particles are engulfed by Paget cells [1][2][3][4], Intense variations of the pigmentation have only excep tionally been reported. The melanisation can be very marked [5,6]; the Japanese, on the other hand, have reported examples of clinical as well as histopathological depigmentation [7],…”

Dopa Oxidase and P 32 Uptake in Extramammary Paget's Disease of the Vulva

“…Glycogen in the form of carminophilic granules was seen occasionally within the cytoplasm of the Paget's cells (Fig. 7,8,9,10,11,12,13,14). Fontana-M asson stain showed occasional dendritic cells containing melanin granules and the presence of fine and coarse melanin granules within the cytoplasm ' of Paget's cells (Fig.…”