Pigmented Epidermotropic Metastasis of a Breast Carcinoma

Bourlond, A

doi:10.1159/000246990

Cited by 25 publications

(18 citation statements)

References 4 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…McDivitt and coworkers 2 reported a heavily pigmented mammary carcinoma clinically confused for malignant melanoma. Similar cases of pigmented epidermotropic metastatic breast carcinoma have since been reported 3–8 . These rare pigmented cutaneous metastases represent a distinct clinicopathologic variant that may be a clinical and histopathologic mimic of malignant melanoma 9 …”

mentioning

confidence: 63%

Cutaneous Metastatic Breast Carcinoma with Melanocyte Colonization: A Clinical and Dermoscopic Mimic of Malignant Melanoma

Wyatt

Agero²,

Delgado

et al. 2006

Dermatol Surg

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 63%

Cutaneous Metastatic Breast Carcinoma with Melanocyte Colonization: A Clinical and Dermoscopic Mimic of Malignant Melanoma

Wyatt

Agero²,

Delgado

et al. 2006

Dermatol Surg

View full text Add to dashboard Cite

show abstract

“…These include (1) proliferation of dendritic melanocytes containing intracytoplasmic melanin between carcinomatous cells 8,13-18 it has been shown that melanocytes may colonize epidermotropic metastasis from breast cancer in other cutaneous locations 8 ; (2) phagocytosis of melanin by carcinomatous cells 19-21 ; and (3) presence of melanophages in the reactive dermal infiltrate. 13,16,19,22 Melanocytic colonization has also been described in other tumors including basal cell carcinoma and porocarcinoma. Several hypotheses have been put forward to explain the mechanism of melanocytic colonization of the tumorous cells, including a melanocytic chemoattractant factor or basic fibroblast growth factor released by the malignant cells.…”

Section: Discussionmentioning

confidence: 98%

Pigmented Paget Disease - A Diagnostic Pitfall Mimicking Melanoma

Petersson¹,

Ivan²,

Kazakov³

et al. 2009

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Pigmented mammary and extramammary Paget disease are rare entities in both males and females that mimic melanoma both clinically and histologically. Furthermore, Paget disease can be associated with increased number of benign melanocytes, thus resulting in additional diagnostic difficulty, especially when only hematoxylin and eosin-stained sections are examined and a limited immunohistochemical study is performed. Using standard hematoxylin and eosin-stained sections and routine immunohistochemical studies, we describe and characterize 7 cases of pigmented extramammary and mammary Paget disease. In all cases, malignant epithelial cells showed intracytoplasmic pigment, along with an immunohistochemical epithelial phenotype. In 2 of the cases, immunohistochemistry revealed numerous dendritic processes positive for melanocytic markers, thus resulting in an initial diagnosis of melanoma. Careful analysis confirmed that the immunolabeling corresponded to cytoplasmic labeling of melanocyte dendrites surrounding tumor cells. The correct diagnosis of pigmented Paget disease can be reached after close histologic examination and detailed evaluation of immunohistochemical studies. The latter are especially important in some extraordinary cases in which there may be an associated intraepithelial melanocytic hyperplasia.

show abstract

“…Paget cells appear as large intraepidermal cells with large nuclei and abundant pale cytoplasm containing mucin. 67,68 It may mimic malignant melanoma both clinically and histopathologically. 8).…”

Section: Mammary Paget Diseasementioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

219

104

View full text Add to dashboard Cite

Skin metastases occur in 0.6%-10.4% of all patients with cancer and represent 2% of all skin tumors. Skin metastases from visceral malignancies are important for dermatologists and dermatopathologists because of their variable clinical appearance and presentation, frequent delay and failure in their diagnosis, relative proportion of different internal malignancies metastasizing to the skin, and impact on morbidity, prognosis, and treatment. Another factor to take into account is that cutaneous metastasis may be the first sign of clinically silent visceral cancer. The relative frequencies of metastatic skin disease tend to correlate with the frequency of the different types of primary cancer in each sex. Thus, women with skin metastases have the following distribution in decreasing order of frequency of primary malignancies: breast, ovary, oral cavity, lung, and large intestine. In men, the distribution is as follows: lung, large intestine, oral cavity, kidney, breast, esophagus, pancreas, stomach, and liver. A wide morphologic spectrum of clinical appearances has been described in cutaneous metastases. This variable clinical morphology included nodules, papules, plaques, tumors, and ulcers. From a histopathologic point of view, there are 4 main morphologic patterns of cutaneous metastases involving the dermis, namely, nodular, infiltrative, diffuse, and intravascular. Generally, cutaneous metastases herald a poor prognosis. The average survival time of patients with skin metastases is a few months. In this article, we review the clinicopathologic and immunohistochemical characteristics of cutaneous metastases from internal malignancies, classify the most common cutaneous metastases, and identify studies that may assist in diagnosing the origin of a cutaneous metastasis.

show abstract

Pigmented Epidermotropic Metastasis of a Breast Carcinoma

Cited by 25 publications

References 4 publications

Cutaneous Metastatic Breast Carcinoma with Melanocyte Colonization: A Clinical and Dermoscopic Mimic of Malignant Melanoma

Cutaneous Metastatic Breast Carcinoma with Melanocyte Colonization: A Clinical and Dermoscopic Mimic of Malignant Melanoma

Pigmented Paget Disease - A Diagnostic Pitfall Mimicking Melanoma

Cutaneous Metastases From Internal Malignancies

Contact Info

Product

Resources

About