MUC1 Predicts Colorectal Cancer Metastasis: A Systematic Review and Meta-Analysis of Case Controlled Studies

Abstract

ObjectiveTo evaluate the predicting value of MUC1 expression in lymph node and distant metastasis of colorectal cancer (CRC).MethodsPubmed/ MEDLINE and EMBASE were searched to identify eligible studies that evaluated the correlation between MUC1 and CRC. A meta-analysis was conducted to evaluate the impact of MUC1 expression on CRC metastasis.ResultsA total of 18 studies (n = 3271) met inclusion criteria and the mean Newcastle-Ottawa Scale (NOS) score was 6.3 with a range from 4 to 8. The pooled OR in the meta-analysis of 15 studies indicated that positive MUC1 expression correlated with more CRC node metastasis (OR = 2.32, 95% CI = 1.63–3.29). The data synthesis of 6 studies suggested that MUC1 expression predicted more possibility of CRC distant metastasis (OR = 2.22, 95% CI = 1.23–4.00). In addition, the combined OR of 7 studies showed that MUC1 expression indicated higher Duke’s stage (OR = 3.02, 95% CI = 2.11–4.33). No publication bias was found in the mate-analysis by Begg’s test or Egger’s test with the exception of the meta-analysis of MUC1 with CRC node metastasis (Begg’s test p = 0.729, Egger’s test p = 0.000).ConclusionsDespite of some modest bias, the pooled evidence suggested that MUC1 expression was significantly correlated with CRC metastasis.

Prognostic and Clinicopathological Significance of MUC Family Members in Colorectal Cancer: A Systematic Review and Meta-Analysis

“…An earlier meta-analysis have shown that abnormal expression of MUC in CRC tissues compared with healthy mucosa plays an important role in the pathogenesis and progression of CRC [73]. Several meta-analyses have explored the association between MUC expression and CRC clinicopathological characteristics [74][75][76]. Furthermore, compared with two earlier meta-analyses for various types of cancer by Xu et al [77] and Huang et al [78], the present analysis not only added additional 26 and 27 studies in colorectal cancer subtype but also examined the correlation between MUC expression and the clinicopathological factors of colorectal cancer.…”

Mucins and associated glycan signatures in colon adenoma–carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer

“…Further, there is overexpression of MUC1 in most colorectal tumors, with expression in the range of 30–100% [22, 23]. Higher expression of MUC1 positively correlates with stage, metastasis, poor tumor differentiation, and worse long-term survival [22-25]. Although our results regarding MUC1 are in accordance with aforementioned findings, its expression did not serve as a statistically significant marker of tumor progression, a deficiency that could be attributed to the limited sample size.…”

A Review on the Scope of Photothermal Therapy–Based Nanomedicines in Preclinical Models of Colorectal Cancer

“…The transmembrane protein, Mucin 1 (MUC1), is associated with increased proliferation and metastasis in CRC 42 In this study, the authors treated HT29 CRC cells with the POSS-PCU functionalised CNT and irradiated cells with NIR light. There was a 95% reduction in cell viability and negligible reduction in cell viability in cell cultures treated with the modified CNT, but not irradiated with NIR light 65 .…”