MTA1 promotes nasopharyngeal carcinoma growth in vitro and in vivo

Song, Qingcui; Zhang, Hong; Wang, Min; Song, Wen; Ying, Min; Fang, Yuan; Li, Yiyi; Chao, Yilan; Zhu, Xiaoxia

doi:10.1186/1756-9966-32-54

Cited by 21 publications

(13 citation statements)

References 21 publications

(28 reference statements)

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“…MTA1 promotes nasopharyngeal carcinoma cell growth via enhancing G1 to S phase transition. 21 Downregulation of MTA1 led to suppression of the protein levels of cyclin D1 in human breast cancer cell. 22 Furthermore, MTA1 promotes cell proliferation by enhancing DNA repair in epithelial ovarian cancer cells.…”

Section: Discussionmentioning

confidence: 99%

MTA1 promotes proliferation and invasion in human gastric cancer cells

Yuan¹,

Feng²,

Xiao³

et al. 2015

OTT

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Although metastasis-associated protein 1 (MTA1) has been widely linked to tumor metastasis, the relevant mechanisms remain to be elucidated, especially in gastric cancer. The aim of this study was to examine whether the MTA1 gene is associated with the process of proliferation and invasion by regulating several molecular targets in gastric cancer. MTA1 expression in 61 gastric cancer tissue and adjacent noncancerous tissues was analyzed by immunohistochemistry. The prognostic value of MTA1 for overall survival and disease-free survival was determined by Kaplan–Meier estimates, and the significance of differences between curves was evaluated by the log-rank test. Furthermore, overexpression of MTA1 in SGC7901 and BGC823 cells promoted cell cycle progression, cell adhesion, and cell invasion. Our study found that MTA1 is overexpressed in gastric cancers, which contributes to malignant cell growth by facilitating cell cycle progression through upregulation of cyclin D1 and accelerates the migration and invasion of human gastric cancer cells by regulating expression of fibronectin and MMP2/MMP9. Taken together, MTA1 was involved in the pathogenesis of gastric cancer and might be a candidate therapeutic target in gastric cancer.

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Section: Discussionmentioning

confidence: 99%

MTA1 promotes proliferation and invasion in human gastric cancer cells

Yuan¹,

Feng²,

Xiao³

et al. 2015

OTT

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“…There are some studies on the effects of estrogen/ERs signaling on various tumor suppressors, but their results are inconclusive. The development and invasion/progression of HCC and other cancers are associated with metastasis-associated protein 1 (MTA1) gene expression [126][127][128]. Additionally, the results of research carried out by Deng et al [129] show that ERα up-regulation inhibits the division and spread of HCC.…”

Section: Hypothesis About the Role Of Ers In Hccmentioning

confidence: 99%

Sex Hormone-Dependent Physiology and Diseases of Liver

Kur

Kolasa

Misiakiewicz-Has

et al. 2020

IJERPH

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Sexual dimorphism is associated not only with somatic and behavioral differences between men and women, but also with physiological differences reflected in organ metabolism. Genes regulated by sex hormones differ in expression in various tissues, which is especially important in the case of liver metabolism, with the liver being a target organ for sex hormones as its cells express estrogen receptors (ERs: ERα, also known as ESR1 or NR3A; ERβ; GPER (G protein-coupled ER, also known as GPR 30)) and the androgen receptor (AR) in both men and women. Differences in sex hormone levels and sex hormone-specific gene expression are mentioned as some of the main variations in causes of the incidence of hepatic diseases; for example, hepatocellular carcinoma (HCC) is more common in men, while women have an increased risk of autoimmune liver disease and show more acute liver failure symptoms in alcoholic liver disease. In non-alcoholic fatty liver disease (NAFLD), the distinction is less pronounced, but increased incidences are suggested among men and postmenopausal women, probably due to an increased tendency towards visceral fat accumulation.

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“…Moreover, in vivo data suggests that an average tumour volume in mice injected with MTA1-depleted C666-1 was reduced by more than 60 %. Eventually, these facts imply that endogenous MTA1 is essential for the proliferation and colony formation of NPC cells [47]. In an attempt to search for novel downstream targets of MTA1 in NPC by Quingsui et al to identify pathways responsible for promoting metastasis, a wide range of genes was found to be targeted by MTA1 which has a profound role in promoting cell cycle control, cytoskeletal reorganization, cell migration, cell survival and angiogenesis.…”

Section: Role Of Mta1 In Other Aspects Of Nasopharyngeal Carcinomamentioning

confidence: 99%

Role of MTA1 in head and neck cancers

Marzook

Deivendran

Kumar

et al. 2014

Cancer Metastasis Rev

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Head and neck cancers usually originate in the squamous cells that line the inner mucosal surfaces of the oral and the neck region. These cancers follow multifocal steps for progression that include risk of developing metastasis. Although therapeutics has advanced in the past decades, head and neck cancers continue to cause much morbidity and mortality. Even with the promising effect of targeted therapies, there is a need for a better evaluation of patients with head and neck cancers. Metastasis-associated tumour antigen 1 (MTA1), a chromatin modifier, is found as an integral part of nucleosome remodelling and histone deacetylation (NuRD) complex. MTA1 is a biomarker for several solid tumours, and the overexpression of which have been documented in various cancers such as breast, ovarian, colon, prostrate etc. Interestingly also, a set of head and neck cancers shows MTA1 overexpression. However, recent evidences from clinical data raise a critical question on the role of MTA1 in head and neck cancers. This calls for a detailed review to the role of MTA1 in oral cancer. This review gives a brief account on the existing biological and molecular data in the context of head and neck cancer invasion and metastasis in relation to MTA1.

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MTA1 promotes nasopharyngeal carcinoma growth in vitro and in vivo

Cited by 21 publications

References 21 publications

MTA1 promotes proliferation and invasion in human gastric cancer cells

MTA1 promotes proliferation and invasion in human gastric cancer cells

Sex Hormone-Dependent Physiology and Diseases of Liver

Role of MTA1 in head and neck cancers

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