MTA1 promotes proliferation and invasion in human gastric cancer cells

Yuan, Yao; Feng, Shuting; Xiao, Mingming; Li, Yan; Yang, Li; Gong, Jiao

doi:10.2147/ott.s85383

Cited by 17 publications

(15 citation statements)

References 25 publications

(27 reference statements)

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“…Our results are consistent with previous studies in various types of cancer. Recently, several studies used a series of in vitro and in vivo experiments to demonstrate that the MTA family members contribute to GC cell proliferation, migration and invasion via dysregulation of downstream target genes, including cyclin D1, interleukin-11, fibronectin, matrix metalloproteinase (MMP)-2 and -9 (40,41). Collectively, these studies together with our data suggest the intimate involvement of the MTA family members in disease progression and formation of metastasis in GC.…”

Section: Discussionsupporting

confidence: 61%

Metastasis-associated protein is a predictive biomarker for metastasis and recurrence in gastric cancer

et al. 2016

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The metastasis-associated (MTA) gene family is a critical component of the nucleosome remodeling and histone deacetylase complex, and plays an important role in metastatic processes. We systematically evaluated dysregulation of the MTA family to clarify their clinical significance in gastric cancer (GC). One hundred and forty-five patients who underwent surgery for GC were evaluated. We analyzed the expression levels of the MTA family (MTA1, 2 and 3) by qPCR in GC tissue, and the MTA1 protein expression in primary cancer and matched normal mucosa (NM) was measured using immunohistochemical analysis. The expression of all the MTA family members was significantly increased in a stage-dependent manner, and elevated expression of all of the MTA family members was correlated with metastatic factors and prognosis in GC patients. Multivariate analysis revealed that MTA1 overexpression was an independent risk factor for survival. Especially, elevated expression of MTA1 was significantly correlated with recurrence, and was an independent risk factor for lymph node metastasis. Immunohistochemical analysis demonstrated that MTA1 was predominantly expressed in the nuclei of primary GC cells but was not expressed in NM and in the cancer stroma. In conclusion, quantification of MTA expression may support the accurate diagnosis of disease staging and may help predict clinical outcomes.

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Section: Discussionsupporting

confidence: 61%

Metastasis-associated protein is a predictive biomarker for metastasis and recurrence in gastric cancer

et al. 2016

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“…Migration assays have been described previously in detail. 6 , 23 Tca-8113 cells (1×10 5 cells in 100 μL DMEM supplemented with 1% FBS) were placed in the top chamber of transwell migration chambers (8 μM BioCoat Control Inserts, BD). The lower chamber was filled with 600 μL DMEM containing 10% FBS.…”

Section: Methodsmentioning

confidence: 99%

Carvacrol suppresses proliferation and invasion in human oral squamous cell carcinoma

Dai¹,

Sun²,

Huang³

et al. 2016

OTT

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Carvacrol, a component of thyme oil, as a novel antitumor agent, has been implicated in several types of cancer cells. However, the mechanisms underlying the effect of carvacrol in human oral squamous cell carcinoma (OSCC) remain unclear. Here, we report that carvacrol significantly inhibits tumor cell proliferation, metastasis and invasion, and induces apoptosis in OSCC. Our results demonstrated that the molecular mechanisms of the effect of carvacrol in Tca-8113 induces G1/S cell cycle arrest through downregulation of CDK regulator CCND1 and CDK4, and upregulation of CDK inhibitor P21. Further analysis demonstrated that carvacrol also inhibited Tca-8113 cells’ clone formation in clonogenic cell survival assay. Student’s t-test (two-tailed) was used to compare differences between groups, and the significance level was P<0.01. Then, treatment of Tca-8113 cells with carvacrol resulted in downregulation of Bcl-2, Cox2, and upregulation of Bax. Carvacrol significantly inhibited the migration and invasion of human OSCC cells by blocking the phosphorylation of FAK and MMP-9 and MMP-2, transcription factor ZEB1, and β-catenin proteins’ expression. Taken together, these results provide novel insights into the mechanism of carvacrol and suggest potential therapeutic strategies for human OSCC.

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“…It would promote invasion, metastasis, and angiogenesis and associate poor clinical outcome tumor by up-regulating the expression of fibronectin, MMP2, or MMP9. 5 , 23 In addition, MTA-1 would also be a positive regulator of cancer cells proliferation. 5 , 24 MTA-1 can also enhance growth of nasopharyngeal carcinoma cells by promoting G1/S-phase transition.…”

Section: Discussionmentioning

confidence: 99%

“… 5 , 23 In addition, MTA-1 would also be a positive regulator of cancer cells proliferation. 5 , 24 MTA-1 can also enhance growth of nasopharyngeal carcinoma cells by promoting G1/S-phase transition. 24 Yao et al 5 reviewed the related research works and indicated that MTA-1 would modulate the cell proliferation and G1/S-phase transition via Cyclin D1 and P21.…”

Section: Discussionmentioning

confidence: 99%

“…A series of studies showed that human pro-oncogene MTA-1 is aberrantly expressed during the metastatic and aggressive process of human cancers, such as breast, lung, liver, ovarian, and prostate cancers. 5 A high level of MTA-1 is associated with proliferation, angiogenesis, and, especially in cancer cells, invasiveness or metastasis. MTA-1 can promote the epithelial–mesenchymal transition (EMT) process by repressing E-cadherin transcription.…”

Section: Introductionmentioning

confidence: 99%

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Expression of microRNA-30c via lentivirus vector inhibits the proliferation and enhances the sensitivity of highly aggressive ccRCC Caki-1 cells to anticancer agents

Yang

Song²,

Guo-rong

et al. 2017

OTT

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The clear cell renal cell carcinoma (ccRCC) is one of the most fatal urologic tumors, and the prognosis remains very poor for advanced or metastatic ccRCC. This study reveals the roles of microRNA (miR)-30c in regulating a highly aggressive ccRCC cell line proliferation by targeting MTA-1, which is a key mediator for human cancer metastasis. Results from quantitative real-time polymerase chain reaction showed that the expression of MTA-1, the target of miR-30c, was significantly higher in metastatic ccRCC specimens than in nonmetastatic ccRCC or nontumor specimens. Accordingly, endogenous miR-30c is at a much lower level in highly aggressive ccRCC Caki-1 cells than nontumor or ccRCC cell lines. Expression of miR-30c via lentivirus vector inhibits the proliferation, anchorage-independent growth, in vitro invasion or migration, or in vivo growth of Caki-1 cells by repressing MTA-1 protein expression. miR-30c also enhances the sensitivity of Caki-1 cells to anticancer agents, including sorafenib and paclitaxel. These data reveal the potential application of miR-30c and that its targeting gene, MTA-1, would be a potential target in metastatic ccRCC treatment.

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MTA1 promotes proliferation and invasion in human gastric cancer cells

Cited by 17 publications

References 25 publications

Metastasis-associated protein is a predictive biomarker for metastasis and recurrence in gastric cancer

Metastasis-associated protein is a predictive biomarker for metastasis and recurrence in gastric cancer

Carvacrol suppresses proliferation and invasion in human oral squamous cell carcinoma

Expression of microRNA-30c via lentivirus vector inhibits the proliferation and enhances the sensitivity of highly aggressive ccRCC Caki-1 cells to anticancer agents

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