MT2‐MMP Expression During Early Avian Morphogenesis

Patterson, Rachel A.; Cavanaugh, Ann M.; Cantemir, Veronica; Brauer, Philip R.; Reedy, Mark V.

doi:10.1002/ar.22618

Cited by 10 publications

(11 citation statements)

References 38 publications

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“…MMP15 does not seems to be expressed in NC cells per se, but it is expressed in the mesoderm underlying the neural tube and the epidermis in the NC pathways. Furthermore, MMP15 is found in pharyngeal arches and the heart (Patterson, Cavanaugh, Cantemir, Brauer, & Reedy, ). MMP16 is expressed in cranial NC cells during migration (Roth, Kalev‐Altman, Monsonego‐Ornan, & Sela‐Donenfeld, ).…”

Section: Metalloproteinases: Promising Outsiders For Signal Integratimentioning

confidence: 99%

Neural crest delamination and migration: Looking forward to the next 150 years

Gouignard

Andrieu

Théveneau

2018

Genesis

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Neural crest (NC) cells were described for the first time in 1868 by Wilhelm His. Since then, this amazing population of migratory stem cells has been intensively studied. It took a century to fully unravel their incredible abilities to contribute to nearly every organ of the body. Yet, our understanding of the cell and molecular mechanisms controlling their migration is far from complete. In this review, we summarize the current knowledge on epithelial-mesenchymal transition and collective behavior of NC cells and propose further stops at which the NC train might be calling in the near future.

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Section: Metalloproteinases: Promising Outsiders For Signal Integratimentioning

confidence: 99%

Neural crest delamination and migration: Looking forward to the next 150 years

Gouignard

Andrieu

Théveneau

2018

Genesis

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“…MMP9 is a secreted protease that localizes to both delaminating and trunk migratory neural crest cells in the chick head and trunk (Monsonego-Ornan et al, 2012), while Xenopus cranial neural crest cells express MMP-14 ( XMT1-MMP ) (Harrison et al, 2004; Tomlinson et al, 2009). MMP15/MT2-MMP , an activator of pro-MMP2, is expressed in the neural folds of the very anterior chick head and open neural plate region in the trunk, while its protein product is observed along the basolateral surface/basement membrane of the neural tube (Patterson, Cavanaugh, Cantemir, Brauer, & Reedy, 2013). In zebrafish, the GPI-linked MMP17b is expressed in crestin -positive cranial neural crest cells, and knockdown of MMP17b function through MOs or chemical inhibitors leads to aberrant migration and patterning of crestin -positive trunk neural crest cells (Leigh et al, 2013).…”

Section: Regulation Of Cadherin Levels Through Posttranslational Mechmentioning

confidence: 99%

Should I stay or should I go? Cadherin function and regulation in the neural crest

Taneyhill

Schiffmacher

2017

Genesis

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Our increasing comprehension of neural crest cell development has reciprocally advanced our understanding of cadherin expression, regulation, and function. As a transient population of multipotent stem cells that significantly contribute to the vertebrate body plan, neural crest cells undergo a variety of transformative processes and exhibit many cellular behaviors, including epithelial-to-mesenchymal-transition (EMT), motility, collective cell migration, and differentiation. Multiple studies have elucidated regulatory and mechanistic details of specific cadherins during neural crest cell development in a highly contextual manner. Collectively, these results reveal that gradual changes within neural crest cells are accompanied by often times subtle, yet important, alterations in cadherin expression and function. The primary focus of this review is to coalesce recent data on cadherins in neural crest cells, from their specification to their emergence as motile cells soon after EMT, and to highlight the complexities of cadherin expression beyond our current perceptions, including the hypothesis that the neural crest EMT is a transition involving a predominantly singular cadherin switch. Further advancements in genetic approaches and molecular techniques will provide greater opportunities to integrate data from various model systems in order to distinguish unique or overlapping functions of cadherins expressed at any point throughout the ontogeny of the neural crest.

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“…For example, mt2-mmp has been reported to be expressed in the pharyngeal arches in both zebrafish and avian embryos (Patterson et al, 2013;Quick et al, 2012). MT2-MMP and, to a lesser extent, MT1-MMP, promote epithelial proliferation during branching morphogenesis in ex vivo mouse submandibular gland cultures.…”

Section: Mt-mmpsmentioning

confidence: 99%

Extracellular metalloproteinases in neural crest development and craniofacial morphogenesis

Christian

Bahudhanapati

Wei

2013

Critical Reviews in Biochemistry and Molecular Biology

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The neural crest (NC) is a population of migratory stem/progenitor cells that is found in early vertebrate embryos. NC cells are induced during gastrulation, and later migrate to multiple destinations and contribute to many types of cells and tissues, such as craniofacial structures, cardiac tissues, pigment cells and the peripheral nervous system. Recently, accumulating evidence suggests that many extracellular metalloproteinases, including matrix metalloproteinases (MMPs), a disintegrin and metalloproteinases (ADAMs), and ADAMs with thrombospondin motifs (ADAMTSs), play important roles in various stages of NC development. Interference with metalloproteinase functions often causes defects in craniofacial structures, as well as in other cells and tissues that are contributed by NC cells, in humans and other vertebrates. In this review, we summarize the current state of the field concerning the roles of these three families of metalloproteinases in NC development and related tissue morphogenesis, with a special emphasis on craniofacial morphogenesis. KeywordsA disintegrin and metalloproteinase, ADAMs with thrombospondin motifs, ADAMTSlike, epithelial to mesenchymal transition, extracellular matrix, matrix metalloproteinase, tissue inhibitors of metalloproteinase History

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MT2‐MMP Expression During Early Avian Morphogenesis

Cited by 10 publications

References 38 publications

Neural crest delamination and migration: Looking forward to the next 150 years

Neural crest delamination and migration: Looking forward to the next 150 years

Should I stay or should I go? Cadherin function and regulation in the neural crest

Extracellular metalloproteinases in neural crest development and craniofacial morphogenesis

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