Mst3b Promotes Spinal Cord Neuronal Regeneration by Promoting Growth Cone Branching Out in Spinal Cord Injury Rats

Zhang, Yuqiang; Hu, Huaiqiang; Tian, Ting; Zhang, Luping; Wu, Qianqian; Chang, Yingwei; Wang, Qingbo; Zhou, Shuai; Feng, Guoying; Huang, Fei

doi:10.1007/s12035-014-8785-7

Cited by 7 publications

(5 citation statements)

References 55 publications

(90 reference statements)

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“…In the KEGG pathway, the MAPK and neurotrophin signaling pathways were the top two signaling pathways affected by the candidate tsRNA-mRNA axes. Previous studies (Zhang et al, 2015;Hodgetts and Harvey, 2017;Fu et al, 2018) have explored the relationships between these pathways and SCI, indicating that MAPK-related molecules regulate the neuronal survival, synaptic function, and neurotransmitter release, and elicit the plasticity and growth of axons within the central nervous system after SCI. Additionally, another report (Keefe et al, 2017) described that the neurotrophins, including NGF, BDNF, and NT-3, targeted specific populations of neurons via their effects on the populations of neurons within diverse spinal tracts.…”

Section: Discussionmentioning

confidence: 99%

Differential Expression Profiles and Functional Prediction of tRNA-Derived Small RNAs in Rats After Traumatic Spinal Cord Injury

Qin

Feng

Zhang

et al. 2020

Front. Mol. Neurosci.

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Section: Discussionmentioning

confidence: 99%

Differential Expression Profiles and Functional Prediction of tRNA-Derived Small RNAs in Rats After Traumatic Spinal Cord Injury

Qin

Feng

Zhang

et al. 2020

Front. Mol. Neurosci.

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“…Moreover, these studies showed that inosine could stimulate neurite outgrowth independently of NGF, in an Mst3b-dependent manner [40]. Mst3b activity was shown subsequently to be required for both optic and radial nerve regeneration in vivo [51], and was shown to be increased by SCI in rats and to promote the regeneration of spinal cord neurons following injury [52]. In the latter study, Mst3b was shown to promote phosphorylation of B-Raf, MEK1 and ERK1/2 in PC-12 cells.…”

Section: Mechanisms Of Actionmentioning

confidence: 98%

Inosine – a Multifunctional Treatment for Complications of Neurologic Injury

Doyle¹,

Cristofaro²,

Sullivan³

et al. 2018

Cell Physiol Biochem

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Spinal cord injury (SCI) caused by trauma or disease leads to motor and sensory abnormalities that depend on the level, severity and duration of the lesion. The most obvious consequence of SCI is paralysis affecting lower and upper limbs. SCI also leads to loss of bladder and bowel control, both of which have a deleterious, life-long impact on the social, psychological, functional, medical and economic well being of affected individuals. Currently, there is neither a cure for SCI nor is there adequate management of its consequences. Although medications provide symptomatic relief for the complications of SCI including muscle spasms, lower urinary tract dysfunction and hyperreflexic bowel, strategies for repair of spinal injuries and recovery of normal limb and organ function are still to be realized. In this review, we discuss experimental evidence supporting the use of the naturally occurring purine nucleoside inosine to improve the devastating sequelae of SCI. Evidence suggests inosine is a safe, novel agent with multifunctional properties that is effective in treating complications of SCI and other neuropathies.

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“…SD rats were randomly divided into six groups: Sham (n = 8), SCI (n = 7), SCI + NC antagonist (n = 6), SCI + miR-155-5p antagonist(n = 8), SCI + NC agomir (n = 7), and SCI + miR-155-5p agomir group (n = 6). The surgical procedure was carried out as previously described [22,23]. Briefly, SD rats received intraperitoneal anesthesia with 1% pentobarbital (30 mg/kg) before spinal cord injury.…”

Section: Establishment Of the Sd Rat Model Of Scimentioning

confidence: 99%

MiR-155-5p Aggravated Astrocyte Activation and Glial Scarring in a Spinal Cord Injury Model by Inhibiting Ndfip1 Expression and PTEN Nuclear Translocation

Chang

Zhang

et al. 2023

Neurochem Res

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Central nervous injury and regeneration repair have always been a hot and difficult scientific questions in neuroscience, such as spinal cord injury (SCI) caused by a traffic accident, fall injury, and war. After SCI, astrocytes further migrate to the injured area and form dense glial scar through proliferation, which not only limits the infiltration of inflammatory cells but also affects axon regeneration. We aim to explore the effect and underlying mechanism of miR-155-5p overexpression promoted astrocyte activation and glial scarring in an SCI model. MiR-155-5p mimic (50 or 100 nm) was used to transfect CTX-TNA2 rat brain primary astrocyte cell line. MiR-155-5p antagonist and miR-155-5p agomir were performed to treat SCI rats. MiR-155-5p mimic dose-dependently promoted astrocyte proliferation, and inhibited cell apoptosis. MiR-155-5p overexpression inhibited nuclear PTEN expression by targeting Nedd4 family interacting protein 1 (Ndfip1). Ndfip1 overexpression reversed astrocyte activation which was induced by miR-155-5p mimic. Meanwhile, Ndfip1 overexpression abolished the inhibition effect of miR-155-5p mimic on PTEN nuclear translocation. In vivo, miR-155-5p silencing improved SCI rat locomotor function and promoted astrocyte activation and glial scar formation. And miR-155-5p overexpression showed the opposite results. MiR-155-5p aggravated astrocyte activation and glial scarring in a SCI model by targeting Ndfip1 expression and inhibiting PTEN nuclear translocation. These findings have ramifications for the development of miRNAs as SCI therapeutics.

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Mst3b Promotes Spinal Cord Neuronal Regeneration by Promoting Growth Cone Branching Out in Spinal Cord Injury Rats

Cited by 7 publications

References 55 publications

Differential Expression Profiles and Functional Prediction of tRNA-Derived Small RNAs in Rats After Traumatic Spinal Cord Injury

Differential Expression Profiles and Functional Prediction of tRNA-Derived Small RNAs in Rats After Traumatic Spinal Cord Injury

Inosine – a Multifunctional Treatment for Complications of Neurologic Injury

MiR-155-5p Aggravated Astrocyte Activation and Glial Scarring in a Spinal Cord Injury Model by Inhibiting Ndfip1 Expression and PTEN Nuclear Translocation

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