MRSA Point Prevalence among Health Care Workers in German Rehabilitation Centers: A Multi-Center, Cross-Sectional Study in a Non-Outbreak Setting

Schubert, Melanie; Kämpf, Daniel; Wahl, Marlena; Hofmann, S; Girbig, Maria; Jatzwauk, Lutz; Peters, Claudia; Nienhaus, Albert; Seidler, Andreas

doi:10.3390/ijerph16091660

Cited by 8 publications

(6 citation statements)

References 25 publications

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“…Schubert et al reported that methicillin resistance was not related to diabetes, hospital admission, chronic respiratory disorder, or antibiotics consumption. But, contact with MRSA patients, and previous history of MRSA colonization were possible factors associated with high frequency of MRSA colonization [40].…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus nasal colonization among health care workers at an Egyptian tertiary care hospital

Allam

Fakhr

Mahmoud³

et al. 2020

Microbes and Infectious Diseases

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Background: Staphylococcus aureus (S. aureus) colonization in health care workers (HCWs) is a major factor of nosocomial infections. Methicillin resistant S. aureus (MRSA) is incriminated in hospital-acquired infection. Objectives: To evaluate the colonization rates of nasal carriage of S. aureus and MRSA among HCWs at Al-Ahrar Teaching Hospital. Methods: We recruited 163 HCWs in a cross section study. Staphylococcus aureus was identified phenotypically by coagulase, with DNase tests and genotypically by nuc gene detection. Antibiotics sensitivity was tested by disk diffusion. Polymerase chain reaction (PCR) for mecA was done to confirm MRSA identification. Results: Forty-eight S. aureus strain were isolated. The frequency of nasal colonization of S. aureus in HCWs was 29.44% (48/163), the frequency of MRSA isolates in HCWs was 27.6% (45/163), and frequency of MRSA isolates among S.aureus isolates was 93.8% (45/48). Prior infection (last 3 months) and living in crowded places increased significantly risk of MRSA nasal carriage by 29.3 and 79.59 folds respectively Conclusion: We demonstrated high rates of nasal carriage of S. aureus and MRSA among HCWs. Prior infection and living in crowded places were risk factors for methicillin resistance among isolated S.aureus strains.

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Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus nasal colonization among health care workers at an Egyptian tertiary care hospital

Allam

Fakhr

Mahmoud³

et al. 2020

Microbes and Infectious Diseases

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“…Similar findings have been observed in German Rehabilitation Centers and the Netherlands where MRSA carriage in health-care workers in contact with livestock is higher than in other health-care workers, though the difference is not statistically significant. 39 , 40 The possible explanation may be due to the likelihood of animal-to-human transmission through kissing, licking, bathing, or other coordinated contacts with colonized animals.…”

Section: Discussionmentioning

confidence: 99%

Nasal Carriage Rate of Staphylococcus aureus, Its Associated Factors, and Antimicrobial Susceptibility Pattern Among Health Care Workers in Public Hospitals, Harar, Eastern Ethiopia

Wolde,

Mitiku,

Sarkar

et al. 2023

IDR

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Background Staphylococcus aureus is the bacteria that colonizes the nasal nares of health-care workers and serves as a reservoir for the spread of pathogen for subsequent infections, mainly Methicillin-resistant Staphylococcus aureus . However, there is a limited study conducted regarding this topic in Harar, Eastern Ethiopia. Objective The main objective of this study was to determine the prevalence of nasal carriage of Staphylococcus aureus , associated factors and antimicrobial susceptibility patterns among health-care workers of public hospitals in Harar, Eastern Ethiopia from May 15 to July 30, 2021. Methods A hospital-based cross-sectional study was conducted on 295 health-care workers. A simple random sampling technique was used to select the participant. Nasal swabs were collected and cultured at 35°C for 24hrs. S. aureus was identified using the coagulase test and catalase test. Methicillin resistance S. aureus (MRSA) was screened using a cefoxitin disc on Muller Hinton agar using the Kirby-Bauer disc diffusion method. Data were entered into EPI-Info version-7 and transferred to SPSS-20 for analysis. Factors associated with nasal carriage of Staphylococcus aureus were determined by using chi-square analysis. A p -value of less than 0.05 was considered statistically significant. Results The prevalence of Staphylococcus aureus in this study was 15.6% (95% CI: 11.7%, 20.3%) and methicillin-resistant Staphylococcus aureus was 11.2% (95% CI: 7.8%, 15.4%), respectively. Age (P < 0.001), work experience (p < 0.001), working unit (p < 0.02), antibiotic use within 3 months (p < 0.001), hand washing habit (p < 0.01), hand rub use (p < 0.001), living with smokers (p < 0.001), living with pets (p < 0.001) and having chronic diseases (p < 0.001) were found significantly associated with Staphylococcus aureus nasal carriage. Conclusion The prevalence of Staphylococcus aureus and Methicillin-resistant Staphylococcus aureus are high in our study. The study emphasizes the need for regular surveillance among hospital staff and the environment to prevent MRSA transmission among health-care personnel.

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“…We also evaluated both donors and recipients for MDROs (CRE, VRE, ESBL) in stool and MRSA in nasopharyngeal samples. The incidence of MDROs including MRSA among donors and recipients was 0.0%, lower than reported point prevalence rates of MRSA colonization among hospital-exposed patients in an urban, nonoutbreak setting [ 50 , 51 ].…”

Section: Resultsmentioning

confidence: 70%

Screening costs associated with donor selection for fecal microbiota transplantation for treatment of PD-1 refractory melanoma patients

Fortman¹,

Avellan

Hurd

et al. 2023

Melanoma Research

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The gut microbiome acts as a tumor-extrinsic regulator of responses to immune-checkpoint inhibitors (ICIs) targeting PD-1 and CTLA-4 receptors. Primary resistance to anti-PD-1 ICI can be reversed via responder-derived fecal microbiota transplant (FMT) in patients with refractory melanoma. Efforts to create stool banks for FMT have proved difficult. Therefore, we aimed to establish a novel donor-screening program to generate responder-derived FMT for use in PD-1 refractory melanoma. Candidate PD-1 responder donors and PD-1 refractory recipients were recruited via clinic-based encounters at the University of Pittsburgh Medical Center hospitals. Eligible donors and recipients underwent physician assessment and screening of serum, stool and nasopharynx for transmissible agents, which included SARS-CoV-2 modification. The cost of donor and recipient screening was calculated. Initially, 29 donors were screened with 14 eligible donors identified after exclusion; of the 14 donors, eight were utilized in clinical trials. The overall efficiency of screening was 48%. Seroprevalence rates for cytomegalovirus, Epstein-Barr virus, HSV-2, HHV-6, HTLV-1, HTLV-2, and syphilis were similar to published statistics from healthy blood donors in the USA. Donor stool studies indicated a 3.6% incidence of E. histolytica and norovirus, 3.7% incidence of giardia and 7.1% incidence of C. difficile. A single donor tested positive for SARS-CoV-2 in stool only. The cost for finding a single eligible donor was $2260.24 (pre-COVID) and $2,460.24 (post-COVID). The observed screening efficiency suggests that a well-resourced screening program can generate sufficient responder-derived donor material for clinical trial purposes. Eliminating testing for low-prevalence organisms may improve cost-effectiveness.

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MRSA Point Prevalence among Health Care Workers in German Rehabilitation Centers: A Multi-Center, Cross-Sectional Study in a Non-Outbreak Setting

Cited by 8 publications

References 25 publications

Staphylococcus aureus nasal colonization among health care workers at an Egyptian tertiary care hospital

Staphylococcus aureus nasal colonization among health care workers at an Egyptian tertiary care hospital

Nasal Carriage Rate of Staphylococcus aureus, Its Associated Factors, and Antimicrobial Susceptibility Pattern Among Health Care Workers in Public Hospitals, Harar, Eastern Ethiopia

Screening costs associated with donor selection for fecal microbiota transplantation for treatment of PD-1 refractory melanoma patients

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