mRNA levels of BACE1 and its interacting proteins, RTN3 and PPIL2, correlate in human post mortem brain tissue

Beyer, Nancy; Coulson, David T.R.; Quinn, Joe G.; Brockbank, Simon; Hellemans, Jan; Irvine, G. Brent; Ravid, Rivka; Johnston, Janet

doi:10.1016/j.neuroscience.2014.05.020

Cited by 3 publications

(1 citation statement)

References 55 publications

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“…PPIL2 has been shown to play a pivotal role in Alzheimer’s disease 24 , but little is known about PPIL2-mediated biological events in cancer. Invasion and metastasis contribute to the poor outcome of patients with breast cancer 25 , 26 .…”

Section: Discussionmentioning

confidence: 99%

U-box ubiquitin ligase PPIL2 suppresses breast cancer invasion and metastasis by altering cell morphology and promoting SNAI1 ubiquitination and degradation

Jia

Wang

et al. 2018

Cell Death Dis

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Metastasis is the leading cause of breast cancer fatalities. To develop new therapeutic strategies, the mechanisms underlying breast cancer invasion and metastasis need to be further investigated. Peptidylprolyl isomerase (cyclophilin)-like 2 (PPIL2) is a U-box-type E3 ubiquitin ligase belonging to the cyclophilin family. Proteins within this family are the major cytosolic binding proteins of the immunosuppressant drug cyclosporine A (CsA). Although PPIL2 has been reported to potentially be involved in cell migration, its role in breast cancer is still unclear. Herein, we demonstrate that PPIL2 suppressed metastasis in a breast cancer model by altering cell morphology and suppressing the epithelial–mesenchymal transition (EMT) process. Moreover, elevated PPIL2 inhibited EMT and breast cancer invasion by interacting with the classical EMT transcription factor, SNAI1, to enhance its ubiquitin-dependent degradation. Furthermore, PPIL2 protein level and stability was upregulated after CsA treatment, indicating that PPIL2 might be involved in CsA-mediated repression of EMT in breast cancer. Analysis of tissue samples taken from breast cancer patients showed a significant correlation between the expression of PPIL2 and the degree of cancer invasion and metastasis. In summary, these results would shed light on a potential clinical use of CsA in breast cancer patients.

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Section: Discussionmentioning

confidence: 99%

U-box ubiquitin ligase PPIL2 suppresses breast cancer invasion and metastasis by altering cell morphology and promoting SNAI1 ubiquitination and degradation

Jia

Wang

et al. 2018

Cell Death Dis

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Epigenetic Control of Response to Toxicants at Environmentally Relevant Concentrations

Wang

2022

Toxicology at Environmentally Relevant Concentrations in Caenorhabditis Elegans

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Epigenetic response to nanopolystyrene in germline of nematode Caenorhabditis elegans

Yang

Wang

2020

Ecotoxicology and Environmental Safety

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mRNA levels of BACE1 and its interacting proteins, RTN3 and PPIL2, correlate in human post mortem brain tissue

Cited by 3 publications

References 55 publications

U-box ubiquitin ligase PPIL2 suppresses breast cancer invasion and metastasis by altering cell morphology and promoting SNAI1 ubiquitination and degradation

U-box ubiquitin ligase PPIL2 suppresses breast cancer invasion and metastasis by altering cell morphology and promoting SNAI1 ubiquitination and degradation

Epigenetic Control of Response to Toxicants at Environmentally Relevant Concentrations

Epigenetic response to nanopolystyrene in germline of nematode Caenorhabditis elegans

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