MRI-visible perivascular spaces are associated with cerebrospinal fluid biomarkers in Parkinson’s disease

Fang, Yi; Gu, Luyan; Tian, Jun; Dai, Shaobing; Chen, Ying; Zheng, Ran; Su, Xiaoli; Jin, Chong‐Yao; Song, Zhe; Yan, Yaping; Yin, Xinzhen; Pu, Jiali; Zhang, Baorong

doi:10.18632/aging.104200

Cited by 17 publications

(13 citation statements)

References 46 publications

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“…Clinical research data have proved that ePVS is a risk factor for cognitive impairment and dementia. The ePVS is an important risk factor for cognitive decline in Parkinson's disease and Alzheimer's disease, as well as vascular cognitive impairment and vascular dementia (21,(41)(42)(43). However, we found no significant difference between MMSE and BG-ePVS score and CSO-ePVS score.…”

Section: Discussioncontrasting

confidence: 74%

Associations Among Diffusion Tensor Image Along the Perivascular Space (DTI-ALPS), Enlarged Perivascular Space (ePVS), and Cognitive Functions in Asymptomatic Patients With Carotid Plaque

Liu

Yang

et al. 2022

Front. Neurol.

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Background and Aim: Carotid atherosclerosis (CAS) is a common pathogenesis of cerebrovascular disease closely related to stroke and silent cerebrovascular disease (SCD), while the insufficient brain perfusion mechanism cannot quite explain the mechanism. The purpose of this study was to utilize diffusion tensor image analysis along the perivascular space (DTI-ALPS) to evaluate the glymphatic system activity and correlated DTI-ALPS with enlarged perivascular spaces (ePVS), carotid intima-media thickening (CIMT), mini-mental state examination (MMSE), and serological indicator in individuals with carotid plaque.Methods: Routine MRI and diffusion tensor images scan of the brain, carotid ultrasound, and blood examination were conducted on 74 individuals (52 carotid plaque subjects, 22 non-carotid plaque subjects), whose demographic and clinical characteristics were also recorded. DTI-ALPS index between patients with carotid plaque and normal controls were acquired and the correlations with other variables were analyzed.Results: The values of ALPS-index in the carotid plaque group was significantly lower compared to normal controls (2.12 ± 0.39, 1.95 ± 0.28, respectively, p = 0.034). The ALPS-index was negatively correlated with the basal ganglia (BG)-ePVS score (r = −0.242, p = 0.038) while there was no significant difference in the centrum semiovale (CSO)-ePVS score. Further analysis showed that there are more high-grade ePVS in the BG compared to the carotid plaque group than in the non-carotid plaque group (84.6% vs. 40.9%, p = 0.001).Conclusions: ALPS-index reflects the glymphatic system of the brain, which is associated with early high-risk cerebrovascular diseases. There may be damage in the function of the glymphatic system which induces the expansion of the perivascular space (PVS) in the BG in individuals with carotid plaque.

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Section: Discussioncontrasting

confidence: 74%

Associations Among Diffusion Tensor Image Along the Perivascular Space (DTI-ALPS), Enlarged Perivascular Space (ePVS), and Cognitive Functions in Asymptomatic Patients With Carotid Plaque

Liu

Yang

et al. 2022

Front. Neurol.

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“…Enlarged perivascular spaces (EPVS) on MRI may reflect impairment of lymphatic drainage channels (Wardlaw et al, 2020). Lower grade of EPVS predicted lower CSF α-syn and t-tau in PD (Fang et al, 2020). However, it has not been established in humans as to whether MRI-visible EPVS are related to DTI ALPS index in PD.…”

Section: Introductionmentioning

confidence: 99%

Diffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease

et al. 2021

Front. Aging Neurosci.

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Background: The aim of this study was to evaluate the glymphatic system activity in patients with Parkinson’s disease (PD) using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) methods.Methods: In total, 71 patients with idiopathic PD and 36 age- and sex-matched normal controls (NCs) were involved. Patients with PD were divided into early (n = 35) and late (n = 36) subgroups, based on Hoehn and Yahr (HY) stages. We calculated the diffusivity along the perivascular spaces (ALPS), as well as projection fibers and association fibers separately, to acquire the ALPS index. Enlarged perivascular spaces (EPVS) and periventricular white matter hyperintensities were also rated. Differences in ALPS index between the PD group and NCs and between two PD subgroups and NCs were compared. In addition, a multivariate logistic regression analysis was conducted to investigate the association between ALPS index and clinical variables.Results: Patients with PD revealed lower ALPS index than NCs (p = 0.010). The late PD group exhibited significantly lower ALPS index than NCs (p = 0.006). However, there were no marked differences noticed in ALPS index between NCs and early PD group and between the two PD subgroups. In the early PD group, there was a significantly positive correlation between ALPS index and Mini-Mental State Examination (MMSE) score (β = 0.021, p = 0.029) and a negative correlation between ALPS index and EPVS score (β = −0.050, p = 0.034), after controlling for multiple variables. In the late PD group, ALPS index was inversely associated with age (β = −0.012, p = 0.004).Conclusion: Impairment of the glymphatic system is involved in PD. DTI-ALPS index could be a promising biomarker of glymphatic system in PD.

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“…Finally, future longitudinal studies should consider mechanistic contributions to ePVS development. For example, longitudinal studies considering the potential contributions of biofluid markers of AD, atrophy, and inflammatory processes to subsequent ePVS development could prove informative (12,14,17,18,86,(91)(92)(93). In particular, the inflammatory processes of arterial stiffening and blood-brain-barrier breakdown are both established markers of cSVD and should be explored as predictors of ePVS development or as modifiers of ePVS effects on global cognition (10,17,24,(94)(95)(96).…”

Section: Limitationsmentioning

confidence: 99%

Enlarged Perivascular Spaces Are Negatively Associated With Montreal Cognitive Assessment Scores in Older Adults

et al. 2022

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Emerging evidence suggests that enlarged perivascular spaces (ePVS) may be a clinically significant neuroimaging marker of global cognitive function related to cerebral small vessel disease (cSVD). We tested this possibility by assessing the relationship between ePVS and both a standardized measure of global cognitive function, the Montreal Cognitive Assessment (MoCA), and an established marker of cSVD, white matter hyperintensity volume (WMH) volume. One hundred and eleven community-dwelling older adults (56–86) underwent neuroimaging and MoCA testing. Quantification of region-specific ePVS burden was performed using a previously validated visual rating method and WMH volumes were computed using the standard ADNI pipeline. Separate linear regression models were run with ePVS as a predictor of MoCA scores and whole brain WMH volume. Results indicated a negative association between MoCA scores and both total ePVS counts (P ≤ 0.001) and centrum semiovale ePVS counts (P ≤ 0.001), after controlling for other relevant cSVD variables. Further, WMH volumes were positively associated with total ePVS (P = 0.010), basal ganglia ePVS (P ≤ 0.001), and centrum semiovale ePVS (P = 0.027). Our results suggest that ePVS burden, particularly in the centrum semiovale, may be a clinically significant neuroimaging marker of global cognitive dysfunction related to cSVD.

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MRI-visible perivascular spaces are associated with cerebrospinal fluid biomarkers in Parkinson’s disease

Cited by 17 publications

References 46 publications

Associations Among Diffusion Tensor Image Along the Perivascular Space (DTI-ALPS), Enlarged Perivascular Space (ePVS), and Cognitive Functions in Asymptomatic Patients With Carotid Plaque

Associations Among Diffusion Tensor Image Along the Perivascular Space (DTI-ALPS), Enlarged Perivascular Space (ePVS), and Cognitive Functions in Asymptomatic Patients With Carotid Plaque

Diffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease

Enlarged Perivascular Spaces Are Negatively Associated With Montreal Cognitive Assessment Scores in Older Adults

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