MRI Screening of <i>BRCA</i> Mutation Carriers: Comparison of Standard Protocol and Abbreviated Protocols With and Without T2-Weighted Images

Naranjo, Isaac Daimiel; Sogani, Julie; Saccarelli, Carolina Rossi; Horvat, João V.; Sevilimedu, Varadan; Hughes, Mary; Gullo, Roberto Lo; Jochelson, Maxine S.; Reiner, Jeffrey S.; Pinker, Katja

doi:10.2214/ajr.21.27022

Cited by 15 publications

(6 citation statements)

References 34 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…113 The aim of abbreviated MRI is to reduce acquisition-and interpretation-times and costs, by only including MRI sequences essential for maintaining high sensitivity. 29 With the use of abbreviated protocols, the implementation of MRI in population and individual-based screening programs can be facilitated faster. Many studies investigated the diagnostic performance of the MRI with a full diagnostic protocol compared to an abbreviated protocol albeit in varying populations and with substantial variation in exact abbreviated protocol-content and duration.…”

Section: Developments In Imaging Methods and Othermentioning

confidence: 99%

“…Abbreviated MRI protocols have emerged as an alternative to standard MRI protocols after the description of the approach by Fischer in 2012 113 . The aim of abbreviated MRI is to reduce acquisition‐ and interpretation‐times and costs, by only including MRI sequences essential for maintaining high sensitivity 29 . With the use of abbreviated protocols, the implementation of MRI in population and individual‐based screening programs can be facilitated faster.…”

Section: Literature Searchmentioning

confidence: 99%

See 1 more Smart Citation

Challenges and Changes of the Breast Cancer Screening Paradigm

Cömert

Gils

Veldhuis

et al. 2022

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Since four decades mammography is used for early breast cancer detection in asymptomatic women and still remains the gold standard imaging modality. However, population screening programs can be personalized and women can be divided into different groups based on risk factors and personal preferences. The availability of new and evolving imaging modalities, for example, digital breast tomosynthesis, dynamic‐contrast‐enhanced magnetic resonance imaging (MRI), abbreviated MRI protocols, diffusion‐weighted MRI, and contrast‐enhanced mammography leads to new challenges and perspectives regarding the feasibility and potential harms of breast cancer screening. The aim of this review is to discuss the current guidelines for different risk groups, to analyze the recent published studies about the diagnostic performance of the imaging modalities and to discuss new developments and future perspectives. Level of Evidence 1 Technical Efficacy Stage 6

show abstract

Section: Developments In Imaging Methods and Othermentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

Challenges and Changes of the Breast Cancer Screening Paradigm

Cömert

Gils

Veldhuis

et al. 2022

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…Since then, several studies have been published on screening high-, intermediate-, and average-risk women and those with dense breasts, using different abbreviated MRI versions (various postcontrast timepoints, MIPs, T2W). [131][132][133][134] Although, some studies used enriched cohorts to assess cancer detection, meta-analyses underline that the sensitivity (pooled sensitivity 0.90%-0.94%) of AB-MRI remains relatively comparable to that of full MRI protocols. 131,133 Remarkably, a recent meta-analysis study demonstrated that this high performance is sustained in more than one screening round with AB-MRI, while the only tumors missed are of low aggressiveness.…”

Section: Mri Techniquesmentioning

confidence: 99%

“…The feasibility of an AB‐MRI protocol in the breast screening setting was first studied by Kuhl et al 130 In their prospective study, scanning time was reduced to 3 minutes, whereas the abbreviated protocol demonstrated equivocal performance compared to the respective full MRI protocol in terms of specificity (94.3% vs. 93.9%) and PPV (24.4% vs. 23.4%). Since then, several studies have been published on screening high‐, intermediate‐, and average‐risk women and those with dense breasts, using different abbreviated MRI versions (various postcontrast timepoints, MIPs, T2W) 131–134 . Although, some studies used enriched cohorts to assess cancer detection, meta‐analyses underline that the sensitivity (pooled sensitivity 0.90%–0.94%) of AB‐MRI remains relatively comparable to that of full MRI protocols 131,133 .…”

Section: Part 2: Novel Imaging Approaches Toward Risk‐adapted Breast ...mentioning

confidence: 99%

New Approaches and Recommendations for Risk‐Adapted Breast Cancer Screening

Tsarouchi

Hoxhaj

Mann

2023

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Population‐based breast cancer screening using mammography as the gold standard imaging modality has been in clinical practice for over 40 years. However, the limitations of mammography in terms of sensitivity and high false‐positive rates, particularly in high‐risk women, challenge the indiscriminate nature of population‐based screening. Additionally, in light of expanding research on new breast cancer risk factors, there is a growing consensus that breast cancer screening should move toward a risk‐adapted approach. Recent advancements in breast imaging technology, including contrast material‐enhanced mammography (CEM), ultrasound (US) (automated‐breast US, Doppler, elastography US), and especially magnetic resonance imaging (MRI) (abbreviated, ultrafast, and contrast‐agent free), may provide new opportunities for risk‐adapted personalized screening strategies. Moreover, the integration of artificial intelligence and radiomics techniques has the potential to enhance the performance of risk‐adapted screening. This review article summarizes the current evidence and challenges in breast cancer screening and highlights potential future perspectives for various imaging techniques in a risk‐adapted breast cancer screening approach.Evidence Level1.Technical EfficacyStage 5.

show abstract

“…Typically, only T1-weighted pre-and post-contrast MRI and DWI or T2 are included in the screening protocols, and while some abbreviated MRI protocols have also explored obtaining more MRI parameters, this is time-consuming and costly [3,15,16,17,18]. Unfortunately, this may lead to missing characteristic information of unscanned MRI sequences, such as T2-weighted MRI, that may sometimes be valuable for breast lesion characterization [19,3,20]. However, since there is an overlap in the physical properties of MRI sequences, a large part of the missing parameters might be deducted from the available sequences.…”

Section: Introductionmentioning

confidence: 99%

IMPORTANT-Net: Integrated MRI Multi-Parameter Reinforcement Fusion Generator with Attention Network for Synthesizing Absent Data

Zhang¹,

Tan²,

Luyi³

et al. 2023

Preprint

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) is highly sensitive for lesion detection in the breasts. Sequences obtained with different settings can capture the specific characteristics of lesions. Such multi-parameter MRI information has been shown to improve radiologist performance in lesion classification, as well as improving the performance of artificial intelligence models in various tasks. However, obtaining multi-parameter MRI makes the examination costly in both financial and time perspectives, and there may be safety concerns for special populations, thus making acquisition of the full spectrum of MRI sequences less durable. In this study, different than naive input fusion or feature concatenation from existing MRI parameters, a novel Integrated MRI Multi-Parameter reinfOrcement fusion generatoR wiTh AtteNTion Network (IMPORTANT-Net) is developed to generate missing parameters. First, the parameter reconstruction module is used to encode and restore the existing MRI parameters to obtain the corresponding latent representation information at any scale level. Then the multi-parameter fusion with attention module enables the interaction of the encoded information from different parameters through a set of algorithmic strategies, and applies different weights to the information through the attention mechanism after information fusion to obtain refined representation information. Finally, a reinforcement fusion scheme embedded in a V − -shape generation module is used to combine the hierarchical representations to generate the missing MRI parameter. Results showed that our IMPORTANT-Net is capable of generating missing MRI parameters and outperforms comparable state-of-the-art networks. Our code is available at https://github.com/Netherlands-Cancer-Institute/MRI_IMPORTANT_NET.

show abstract

MRI Screening of BRCA Mutation Carriers: Comparison of Standard Protocol and Abbreviated Protocols With and Without T2-Weighted Images

Cited by 15 publications

References 34 publications

Challenges and Changes of the Breast Cancer Screening Paradigm

Challenges and Changes of the Breast Cancer Screening Paradigm

New Approaches and Recommendations for Risk‐Adapted Breast Cancer Screening

IMPORTANT-Net: Integrated MRI Multi-Parameter Reinforcement Fusion Generator with Attention Network for Synthesizing Absent Data

Contact Info

Product

Resources

About