MRI Negative Myelitis Induced by Pfizer-BioNTech COVID-19 Vaccine

Cabral, Gonçalo; Gonçalves, Carolina; Serrazina, Filipa; Sá, Francisca

doi:10.3988/jcn.2022.18.1.120

Cited by 10 publications

(13 citation statements)

References 10 publications

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“…The PRISMA flowchart ( Figure 1 ) showed a search strategy for our review. The present study consisted of 28 studies, including 26 case reports, one case series, and one cross-sectional, and the pooled data of 31 patients with COVID-19 vaccine-associated ATM is extracted ( Sriwastava et al, 2021 , Sepahvand et al, 2022 , Tan et al, 2021 , Corrêa et al, 2021 , Vegezzi et al, 2021 , Hsiao et al, 2021 , Pagenkopf and Südmeyer, 2021 , Notghi et al, 2021 , Gao et al, 2021 , Malhotra et al, 2021 , Khan et al, 2022 , Erdem et al, 2021 , Hirose et al, 2021 , Tahir et al, 2021 , Miyaue et al, 2021 , Fujikawa et al, 2021 , Kaulen et al, 2022 , McLean and Trefts, 2021 , Alabkal et al, 2021 , Fitzsimmons and Nance, 2021 , Nakano et al, 2022 , Spataro et al, 2022 , Cabral et al, 2022 , Khan et al, 2022 , Maroufi et al, 2022 , Eom et al, 2022 , Netravathi et al, 2022 , Esechie et al, 2022 ). All of the selected studies were written in the English language.…”

Section: Resultsmentioning

confidence: 99%

Clinical characteristics, radiological features and prognostic factors of transverse myelitis following COVID-19 vaccination: A systematic review

Ostovan¹,

Sahraian²,

Karazhian³

et al. 2022

Multiple Sclerosis and Related Disorders

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Section: Resultsmentioning

confidence: 99%

Clinical characteristics, radiological features and prognostic factors of transverse myelitis following COVID-19 vaccination: A systematic review

Ostovan¹,

Sahraian²,

Karazhian³

et al. 2022

Multiple Sclerosis and Related Disorders

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“…Molecular mimicry, epitope spreading, or polyclonal activation of B lymphocytes are possible mechanisms. 8 , 12 ) Bhat et al reported an association between TM and autoimmune diseases. 16 ) Our patient had no history of autoimmune diseases, but an anti-SSA antibody associated with Sjögren's syndrome was elevated.…”

Section: Discussionmentioning

confidence: 99%

“… 8 ) Several TM cases reportedly occurred following administration of different vaccines, such as hepatitis B virus, human papillomavirus, seasonal influenza, measles-mumps-rubella, polio, and diphtheria, that occurred from a few days to 3 months after vaccination. 12 ) Currently, over ten cases of TM-associated COVID-19 vaccination have been reported. An exclusion diagnosis usually diagnoses TM, and its differential diagnoses include neuromyelitis optica spectrum disorder (NMOSD), multiple sclerosis (MS), and infectious causes.…”

Section: Discussionmentioning

confidence: 99%

Cervical Transverse Myelitis Following COVID-19 Vaccination

DOI¹,

Ohara

OUCHI

et al. 2022

NMC Case Report Journal

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Various COVID-19 vaccines are associated with numerous adverse side effects. Associations between vaccinations and neurological disorders, such as transverse myelitis, stroke, Bell's palsy, acute disseminated encephalomyelitis, and Guillain-Barré syndrome, have been reported. A 27-year-old Japanese woman presented with paresthesia four days after receiving a second dose of the COVID-19 vaccine. One month after vaccination, she started to feel left lower limb weakness, and her symptoms almost improved after two steroid pulse therapies. Spinal cord tumor biopsy could potentially help make a definitive diagnosis in clinical situations. However, it is very important to review the patient's medical history, including vaccinations received, before performing a direct spinal cord biopsy, which is invasive and does not guarantee a definitive diagnosis.

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“… 4 Notably, all cases showed partial or no improvement after management, whereas our patient demonstrated an almost complete resolution of symptoms. Interestingly, Cabral et al 16 reported recently a case of MRI-negative transverse myelitis induced by the COVID-19 vaccine in a 33-year-old male; complete resolution of symptoms was described after 3 months.…”

Section: Discussionmentioning

confidence: 99%

MRI-negative myelitis associated with cerebral venous thrombosis after COVID-19 infection

et al. 2022

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Transverse myelitis and cerebral venous thrombosis represent some of the described neurological complications of coronavirus disease. A woman in her early 30s presented with headache, left-sided sensory symptoms and voiding difficulty. The patient also reported dry cough, fever, nasal congestion, anosmia and ageusia 2 weeks before presentation. The clinical examination showed sensory disturbances on the left side of the body, starting from the lower abdomen and extending to the left leg, which was consistent with transverse myelitis. The laboratory assessment confirmed a previous infection with coronavirus disease and excluded autoimmune entities. Radiological investigations revealed left transverse sinus thrombosis with no spinal cord abnormalities. The treatment was started with therapeutic anticoagulation and intravenous high-dose steroids. The patient showed significant improvement, and the neurological deficits resolved after 3 months. This is the first documented case of imaging-negative myelitis associated with cerebral venous thrombosis after coronavirus disease.

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MRI Negative Myelitis Induced by Pfizer-BioNTech COVID-19 Vaccine

Cited by 10 publications

References 10 publications

Clinical characteristics, radiological features and prognostic factors of transverse myelitis following COVID-19 vaccination: A systematic review

Clinical characteristics, radiological features and prognostic factors of transverse myelitis following COVID-19 vaccination: A systematic review

Cervical Transverse Myelitis Following COVID-19 Vaccination

MRI-negative myelitis associated with cerebral venous thrombosis after COVID-19 infection

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