Clinical characteristics, radiological features and prognostic factors of transverse myelitis following COVID-19 vaccination: A systematic review

Ostovan, Vahid Reza; Sahraian, Mohammad Ali; Karazhian, Neda; Rostamihosseinkhani, Mahtab; Salimi, Marzieh; Marbooti, Hoda

doi:10.1016/j.msard.2022.104032

Cited by 10 publications

(18 citation statements)

References 58 publications

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“…Besides myocarditis/pericarditis due to SARS-CoV-2 infection/COVID-19 and COVID-19 vaccination, other severe health conditions were observed, including neurological ones and issues by the reactivation of chronic infections. For example, transverse myelitis has been documented due to COVID-19 [180] , [181] , [182] , [183] , [184] , [185] , [186] and COVID-19 vaccination [187] , [188] , [189] , [190] , [191] , [192] , [193] , [194] . In addition, VZV and herpes simplex virus, cytomegalovirus and Epstein-Barr virus reactivation was found to be possibly occurring due to COVID-19 [11] , [12] , [195] , [196] , [197] , [198] , [199] , [200] , [201] , [202] , [203] , [204] and COVID-19 vaccination [205] , [206] , [207] , [208] , [209] , [210] , [211] , [212] , [213] .…”

Section: Sars-cov-2 Infection- and Covid-19 Vaccination-induced Syndr...mentioning

confidence: 99%

COVID-19, post-acute COVID-19 syndrome (PACS, “long COVID”) and post-COVID-19 vaccination syndrome (PCVS, “post-COVIDvac-syndrome”): Similarities and differences

Scholkmann

May

2023

Pathology - Research and Practice

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Section: Sars-cov-2 Infection- and Covid-19 Vaccination-induced Syndr...mentioning

confidence: 99%

COVID-19, post-acute COVID-19 syndrome (PACS, “long COVID”) and post-COVID-19 vaccination syndrome (PCVS, “post-COVIDvac-syndrome”): Similarities and differences

Scholkmann

May

2023

Pathology - Research and Practice

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“…Age seems to be a poor prognostic factor of neurological adverse events. A systemic review noted that older age, higher modified Rankin scale (MRS), and second dose of vaccine presented a worse outcome in patients with COVID-19 vaccine myelitis [ 18 ]. According to the Sisonke’s study of Ad26.COV2.S, the median age of participants was 42 years and the majority were women.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Neurological Complications after COVID-19 Vaccination: Report of the Clinical Scenarios and Review of the Literature

Chen

Shang

et al. 2023

Vaccines

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Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), broke out in 2019 and became a pandemic in 2020. Since then, vaccines have been approved to prevent severe illness. However, vaccines are associated with the risk of neurological complications ranging from mild to severe. Severe complications such as vaccine-induced immune thrombotic thrombocytopenia (VITT) associated with acute ischaemic stroke have been reported as rare complications post-COVID-19 vaccination. During the pandemic era, VITT evaluation is needed in cases with a history of vaccination within the last month prior to the event. Cerebral venous sinus thrombosis (CVST) should be suspected in patients following immunization with persistent headaches who are unresponsive to analgesics. In this article, we investigated neurological complications after COVID-19 vaccination and provided more subsequent related clinical studies of accurate diagnosis, pathophysiological mechanisms, incidence, outcome, and management.

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“…Interestingly, there were quite a few reports of a subtype called longitudinally extended transfer myelitis, which involves three or more vertebral segments [ 91 ]. The mean age of patients was typically in the 40 s to 50 s, and a large proportion of patients had previous autoimmune diseases [ 92 , 93 ]. Compared with COVID-19-related ATMs, vaccine-related ones show shorter intervals and milder clinical manifestations [ 92 , 93 ].…”

Section: Discussionmentioning

confidence: 99%

“…The mean age of patients was typically in the 40 s to 50 s, and a large proportion of patients had previous autoimmune diseases [ 92 , 93 ]. Compared with COVID-19-related ATMs, vaccine-related ones show shorter intervals and milder clinical manifestations [ 92 , 93 ]. They occur after various types of COVID-19 vaccines, with the adenoviral vector-based vaccine being the most common [ 91 , 94 , 95 , 96 ].…”

Section: Discussionmentioning

confidence: 99%

Neurological Disorders following COVID-19 Vaccination

Yang

Huang

2023

Vaccines

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Nowadays, people all over the world have been receiving different types of coronavirus disease 2019 (COVID-19) vaccines. While their effectiveness has been well recognized, various post-vaccination disorders are not fully understood. In this review, we discuss neurological disorders related to vascular, immune, infectious, and functional factors following COVID-19 vaccination, and attempt to provide neuroscientists, psychiatrists, and vaccination staff with a reference for the diagnosis and treatment of these diseases. These disorders may present as a recurrence of previous neurological disorders or new-onset diseases. Their incidence rate, host and vaccine characteristics, clinical manifestations, treatment, and prognosis differ significantly. The pathogenesis of many of them remains unclear, and further studies are needed to provide more evidence. The incidence rate of severe neurological disorders is relatively low, most of which are reversible or treatable. Therefore, the benefits of vaccination outweigh the risk of COVID-19 infection, especially among fragile populations.

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Clinical characteristics, radiological features and prognostic factors of transverse myelitis following COVID-19 vaccination: A systematic review

Cited by 10 publications

References 58 publications

COVID-19, post-acute COVID-19 syndrome (PACS, “long COVID”) and post-COVID-19 vaccination syndrome (PCVS, “post-COVIDvac-syndrome”): Similarities and differences

COVID-19, post-acute COVID-19 syndrome (PACS, “long COVID”) and post-COVID-19 vaccination syndrome (PCVS, “post-COVIDvac-syndrome”): Similarities and differences

Investigation of Neurological Complications after COVID-19 Vaccination: Report of the Clinical Scenarios and Review of the Literature

Neurological Disorders following COVID-19 Vaccination

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