MRI atlas of human white matter

Ling, Chan Ling; Rumpel, Helmut

doi:10.1002/cmr.a.20052

Cited by 3 publications

(4 citation statements)

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“…It was thresholded with the default threshold value of 0.2. Masks were created for studying specific tracts of interest using the JHU Atlas (Ling & Rumpel, 2006), binarized, and mean FA, MD and RD values were extracted from the tracts of each participant. Tracts of interests are presented in Figure 1.…”

Section: Methodsmentioning

confidence: 99%

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Cognitive outcome and its neural correlates after cardiorespiratory arrest in childhood

Geva,

Hoskote,

Saini

et al. 2024

Developmental Science

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Hypoxia‐ischaemia (HI) can result in structural brain abnormalities, which in turn can lead to behavioural deficits in various cognitive and motor domains, in both adult and paediatric populations. Cardiorespiratory arrest (CA) is a major cause of hypoxia‐ischaemia in adults, but it is relatively rare in infants and children. While the effects of adult CA on brain and cognition have been widely studied, to date, there are no studies examining the neurodevelopmental outcome of children who suffered CA early in life. Here, we studied the long‐term outcome of 28 children who suffered early CA (i.e., before age 16). They were compared to a group of control participants (n = 28) matched for age, sex and socio‐economic status. The patient group had impairments in the domains of memory, language and academic attainment (measured using standardised tests). Individual scores within the impaired range were most commonly found within the memory domain (79%), followed by academic attainment (50%), and language (36%). The patient group also had reduced whole brain grey matter volume, and reduced volume and fractional anisotropy of the white matter. In addition, lower performance on memory tests was correlated with bilaterally reduced volume of the hippocampi, thalami, and striatum, while lower attainment scores were correlated with bilateral reduction of fractional anisotropy in the superior cerebellar peduncle, the main output tract of the cerebellum. We conclude that patients who suffered early CA are at risk of developing specific cognitive deficits associated with structural brain abnormalities.Research Highlights Our data shed light on the long‐term outcome and associated neural mechanisms after paediatric hypoxia‐ischaemia as a result of cardiorespiratory arrest. Patients had impaired scores on memory, language and academic attainment. Memory impairments were associated with smaller hippocampi, thalami, and striatum. Lower academic attainment correlated with reduced fractional anisotropy of the superior cerebellar peduncle.

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Section: Methodsmentioning

confidence: 99%

“…White matter tracts and grey matter structures of interest. Top panel: white matter tracts of interest (JHU Atlas; Ling and Rumpel, 2006): Yellow: superior cerebellar peduncle, Red: ILF/IFOF, Green: AF/SLF, Blue: Fornix. Bottom panel: grey matter regions of interest: Blue: hippocampus, Orange: putamen, Red: thalamus, Green: caudate nucleus.…”

Section: Methodsmentioning

confidence: 99%

Cognitive outcome and its neural correlates after cardiorespiratory arrest in childhood

Geva,

Hoskote,

Saini

et al. 2024

Developmental Science

View full text Add to dashboard Cite

show abstract

“…Inferences were performed using whole-brain family-wise corrected p -values with a threshold set at p < 0.05, at the cluster level (cluster forming threshold at p < 0.0001 uncorrected rather than p < 0.001, in order to favor parsimony in the construction of the model; k = number of voxels in the cluster). For anatomical labeling, the Harvard-Oxford Cortical structural atlas for gray matter ( Frazier et al., 2005 ), and the John Hopkins University (JHU) white matter tractography atlas ( Ling and Rumpel, 2006 ) were used.…”

Section: Methodsmentioning

confidence: 99%

Association between sleep slow-wave activity and in-vivo estimates of myelin in healthy young men

et al. 2023

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“…4 ), segmented region of interests (ROIs) of the CC (i.e. genu, body and splenium) were extracted using the John Hopkins University DTI-based white-matter atlas ( Ling and Rumpel, 2006 ; Wakana et al , 2007 ; Hua et al , 2008 ). ROIs were then warped back into native space using concatenated, and inversed, linear and non-linear transformations that registered anatomical images to standard template space ( Fig.…”

Section: Methodsmentioning

confidence: 99%

Novel strain analysis informs about injury susceptibility of the corpus callosum to repeated impacts

Champagne

Peponoulas

Terem

et al. 2019

Brain Communications

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Increasing evidence for the cumulative effects of head trauma on structural integrity of the brain has emphasized the need to understand the relationship between tissue mechanic properties and injury susceptibility. Here, diffusion tensor imaging, helmet accelerometers and amplified magnetic resonance imaging were combined to gather insight about the region-specific vulnerability of the corpus callosum to microstructural changes in white-matter integrity upon exposure to sub-concussive impacts. A total of 33 male Canadian football players (meanage = 20.3 ± 1.4 years) were assessed at three time points during a football season (baseline pre-season, mid-season and post-season). The athletes were split into a LOW (N = 16) and HIGH (N = 17) exposure group based on the frequency of sub-concussive impacts sustained on a per-session basis, measured using the helmet-mounted accelerometers. Longitudinal decreases in fractional anisotropy were observed in anterior and posterior regions of the corpus callosum (average cluster size = 40.0 ± 4.4 voxels; P < 0.05, corrected) for athletes from the HIGH exposure group. These results suggest that the white-matter tract may be vulnerable to repetitive sub-concussive collisions sustained over the course of a football season. Using these findings as a basis for further investigation, a novel exploratory analysis of strain derived from sub-voxel motion of brain tissues in response to cardiac impulses was developed using amplified magnetic resonance imaging. This approach revealed specific differences in strain (and thus possibly stiffness) along the white-matter tract (P < 0.0001) suggesting a possible signature relationship between changes in white-matter integrity and tissue mechanical properties. In light of these findings, additional information about the viscoelastic behaviour of white-matter tissues may be imperative in elucidating the mechanisms responsible for region-specific differences in injury susceptibility observed, for instance, through changes in microstructural integrity following exposure to sub-concussive head impacts.

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MRI atlas of human white matter

Cited by 3 publications

References 0 publications

Cognitive outcome and its neural correlates after cardiorespiratory arrest in childhood

Cognitive outcome and its neural correlates after cardiorespiratory arrest in childhood

Association between sleep slow-wave activity and in-vivo estimates of myelin in healthy young men

Novel strain analysis informs about injury susceptibility of the corpus callosum to repeated impacts

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