Association between sleep slow-wave activity and in-vivo estimates of myelin in healthy young men

Deantoni, Michele; Baillet, Marion; Hammad, G. H.; Berthomier, Christian; Reyt, Mathilde; Jaspar, Mathieu; Meyer, C; Egroo, Maxime Van; Talwar, Puneet; Lambot, Eric; Chellappa, Sarah Laxhmi; Degueldre, Christian; Luxen, André; Salmon, Éric; Balteau, Evelyne; Phillips, Christophe; Dijk, Derk‐Jan; Vandewalle, Gilles; Collette, Fabienne; Maquet, Pierre; Muto, Vincenzo; Schmidt, Christina

doi:10.1016/j.neuroimage.2023.120045

Cited by 3 publications

(1 citation statement)

References 91 publications

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“…Alternatively, our finding may also be incidental and arise from phenomenon that would both affect sleep and myelin. This phenomenon may also arguably be in part genetic which dictate brain myelin content and therefore affect sleep 26 , 45 .…”

Section: Discussionmentioning

confidence: 99%

In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men

Talwar,

Deantoni,

Van Egroo

et al. 2023

Sci Rep

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The regional integrity of brain subcortical structures has been implicated in sleep–wake regulation, however, their associations with sleep parameters remain largely unexplored. Here, we assessed association between quantitative Magnetic Resonance Imaging (qMRI)-derived marker of the myelin content of the brainstem and the variability in the sleep electrophysiology in a large sample of 18-to-31 years healthy young men (N = 321; ~ 22 years). Separate Generalized Additive Model for Location, Scale and Shape (GAMLSS) revealed that sleep onset latency and slow wave energy were significantly associated with MTsat estimates in the brainstem (pcorrected ≤ 0.03), with overall higher MTsat value associated with values reflecting better sleep quality. The association changed with age, however (MTsat-by-age interaction—pcorrected ≤ 0.03), with higher MTsat value linked to better values in the two sleep metrics in the younger individuals of our sample aged ~ 18 to 20 years. Similar associations were detected across different parts of the brainstem (pcorrected ≤ 0.03), suggesting that the overall maturation and integrity of the brainstem was associated with both sleep metrics. Our results suggest that myelination of the brainstem nuclei essential to regulation of sleep is associated with inter-individual differences in sleep characteristics during early adulthood. They may have implications for sleep disorders or neurological diseases related to myelin.

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Section: Discussionmentioning

confidence: 99%

In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men

Talwar,

Deantoni,

Van Egroo

et al. 2023

Sci Rep

Self Cite

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show abstract

Sleep deprivation enhances amyloid beta peptide, p-tau and serotonin in the brain: Neuroprotective effects of nanowired delivery of cerebrolysin with monoclonal antibodies to amyloid beta peptide, p-tau and serotonin

Sharma,

Feng,

Muresanu

et al. 2023

International Review of Neurobiology

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In vivomarker of brainstem myelin is associated to quantitative sleep parameters in healthy young men

Talwar

Deantoni

Egroo

et al. 2023

Preprint

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Brain structural integrity has been suggested to contribute to the variability in human sleep quality and composition. The associations between sleep parameters and the regional integrity of subcortical structures implicated in sleep-wake regulation remain, however, largely unexplored. The present study aimed at assessing association between quantitative Magnetic Resonance Imaging (qMRI)-derived marker of the myelin content of the brainstem with the variability in the sleep electrophysiology in a large sample of healthy young men (N=321; ~22y). Generalized Additive Model for Location, Scale and Shape (GAMLSS) was used to seek associations between sleep metrics and Magnetisation Transfer saturation (MTsat) qMRI values, proxy for myelin content. Separate GAMLSS revealed that sleep onset latency and slow wave sleep intensity were significantly associated with MTsat-derived myelin estimates in the brainstem (pcorrected≤.03), with overall higher MTsat value associated with values reflecting better sleep quality. The association changed with age, however (MTsat-by-age interaction - pcorrected≤.03), with higher MTsat value linked to better values in the two sleep metrics in the individuals of our sample aged ~18 to 20y. Similar associations were detected across different parts of the brainstem (pcorrected≤.03), suggesting that the overall maturation and integrity of the brainstem was associated with both sleep metrics. Our results suggest that myelination of the many reticular nuclei of the brainstem essential to regulation of sleep is associated with inter-individual differences in sleep characteristics during early adulthood. They may have implications for sleep disorders or neurological diseases related to myelin.

show abstract

Association between sleep slow-wave activity and in-vivo estimates of myelin in healthy young men

Cited by 3 publications

References 91 publications

In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men

In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men

Sleep deprivation enhances amyloid beta peptide, p-tau and serotonin in the brain: Neuroprotective effects of nanowired delivery of cerebrolysin with monoclonal antibodies to amyloid beta peptide, p-tau and serotonin

In vivomarker of brainstem myelin is associated to quantitative sleep parameters in healthy young men

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