MR Neurography: Advances

Chhabra, Avneesh; Zhao, Lianxin; Carrino, John A.; Trueblood, Eo; Koceski, Saso; Shteriev, Filip; Lenkinski, Lionel; Sinclair, C.D.J.; Andreisek, Gustav

doi:10.1155/2013/809568

Cited by 54 publications

(50 citation statements)

References 56 publications

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“…128 With improved detection of nerve anatomy and pathology, the value of MRN as a potential biomarker of nerve effects of DPN has been increasingly recognized. 129,130 MRN is aimed at supressing vascular and fat signal to create unique tissue selective images. This method is based on T2 weighted sequences with fat suppression, which provides excellent depiction of the peripheral nerves.…”

Section: Non-invasive Mri Techniques To Assess Dpn Featuresmentioning

confidence: 99%

Declining Skeletal Muscle Function in Diabetic Peripheral Neuropathy

Parasoglou

Rao

Slade

2017

Clinical Therapeutics

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Purpose In this review, we highlight the current concepts in the effects of diabetic peripheral neuropathy (DPN) in skeletal muscle. We discuss the lack of effective pharmacological treatments and the role of physical exercise intervention in limb protection and symptom reversal. We also highlight the importance of Magnetic Resonance Imaging (MRI) techniques in providing a mechanistic understanding of the disease and helping develop targeted treatments. Methods This review provides a comprehensive reporting on the effects of DPN in the skeletal muscle of diabetic patients. It also provides an update on the most recent trials of exercise intervention targeting DPN pathology. Lastly, we report on emerging MRI techniques that have shown promise in providing a mechanistic understanding of DPN and can help improve the design and implementation of clinical trials in the future. Findings Impairments in lower limb muscles reduce functional capacity and contribute to altered gait, increased fall risk, and impaired balance in patients with DPN. This is an important concern for DPN patients as their falls are very likely to be injurious, and lead to bone fractures, poorly healing wounds, and chronic infections that may require amputation. Preliminary studies have shown that moderate intensity exercise programs are well tolerated by patients with DPN. They can improve their cardiorespiratory function and can partially reverse some of the DPN symptoms. MRI has the potential to bring new mechanistic insights into the effects of DPN as well as to objectively measure small changes in DPN pathology as a result of intervention. Implications Non-invasive exercise intervention is particularly valuable in DPN due to its safety, low cost, and potential to augment pharmacological interventions. As we gain a better mechanistic understanding of the disease, more targeted and effective interventions can be designed.

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Section: Non-invasive Mri Techniques To Assess Dpn Featuresmentioning

confidence: 99%

Declining Skeletal Muscle Function in Diabetic Peripheral Neuropathy

Parasoglou

Rao

Slade

2017

Clinical Therapeutics

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“…1 Magnetic resonance neurography (MRN) is an increasingly used diagnostic tool to visualize peripheral nerve pathology including inflammatory, metabolic, degenerative, compressive, traumatic, or neoplastic conditions. [2][3][4][5][6] Several studies have established distinct MRN criteria in various diseases at specific anatomical sites. 1,7-10 Spatial identification of nerve lesions for some neuropathies has previously not been possible using conventional clinical and electrophysiological diagnostic tools.…”

mentioning

confidence: 99%

Diffusion Tensor Imaging Adds Diagnostic Accuracy in Magnetic Resonance Neurography

Breckwoldt

Stock

Xia

et al. 2015

Investigative Radiology

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“…The identification and localization of site of injury in fascicles/nerves is done by FES, precise imaging by advanced magnetic resonance neurography imaging system (Chhabra et al, 2013) and modern imaging techniques with high resolution or 3D colored sonography. Improvement in accurate interpretation of these tools can be done by knowing the classified femoral nerve variations and fascicular organization models described in fascicular anatomy section.…”

Section: Discussionmentioning

confidence: 99%

Classification and Fascicular Analysis of Variant Branching Pattern of Femoral Nerve for Microsurgical Intervention: A Series of Thirteen Cadavers

2016

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SINGH, R.; TUBBS, S. & SINGLA, M.Classification and fascicular analysis of variant branching pattern of femoral nerve for microsurgical intervention. A series of thirteen cadavers. Int. J. Morphol., 34(2):561-569, 2016. SUMMARY:Femoral neuropathy associated with lower limb is treated by surgical intervention through activation/regeneration/ grafting of nerve fibers by a nerve cuff electrode implant or neuro-prosthesis. These procedures require detailed and precise knowledge of neuro-anatomical variants of the femoral nerve and its fascicular anatomy so that the nerve injury can be investigated and treated more efficiently. The aim of the study is to uncover the variations both in the femoral nerve and its branches, to classify them and to bring out corresponding fascicular anatomy using a hypothesis based on the principle of consistency, continuity and traceability of fascicles. The study was carried out in the Department of Anatomy AIIMS Rishikesh using 13 matched lower limbs (26 femoral nerves) from 13 cadavers. The femoral nerve was exposed in the femoral triangle and traced to the posterior abdominal wall. Variations in the shape, size and course of the femoral nerve and its branches were analyzed. The fascicular arrangement was also conceptualized based on the hypothesis. Seven classes, high division, trunk anomaly, semi-scattered, scattered branching pattern, pectocutaneous, lateral cutaneous nerve of thigh and nerve to sartorius anomalies were detected. The corresponding fascicular organizations were modeled. The seven classes along with corresponding fascicular pattern will be very useful for neurosurgeons, radiologists, anesthetists and anatomists in diagnosis and treatment of femoral neuropathy.

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MR Neurography: Advances

Cited by 54 publications

References 56 publications

Declining Skeletal Muscle Function in Diabetic Peripheral Neuropathy

Declining Skeletal Muscle Function in Diabetic Peripheral Neuropathy

Diffusion Tensor Imaging Adds Diagnostic Accuracy in Magnetic Resonance Neurography

Classification and Fascicular Analysis of Variant Branching Pattern of Femoral Nerve for Microsurgical Intervention: A Series of Thirteen Cadavers

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