MR measurement of blood flow in the parotid gland without contrast medium: a functional study before and after gustatory stimulation

Schwenzer, Nina F.; Schraml, Christina; Martirosian, Petros; Boss, Andreas; Claussen, Claus D.; Schick, Fritz

doi:10.1002/nbm.1231

Cited by 19 publications

(29 citation statements)

References 44 publications

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“…Thus, only the estimated parameters of model 1 were further used. The values of the estimated physiological parameters (Table 2) compare favorably to literature values, i.e., they are in a physiologically reasonable range [11, 14, 16, 42]. The results of each individual patient are presented in S2.…”

Section: Resultsmentioning

confidence: 59%

“…Abbreviation: [R i,0 ] binding site density of kidneys, salivary glands and tumor, λ i,release release rate of kidneys, salivary glands and tumor, f SAL serum flow per mass of salivary glands a Assuming 10 12 cells/l and 180.000 [16] and 800.000 [14] copies of PSMA/cell from in vitro measurements b For 111 In-DOTATATE [11] c [42] non-stimulated blood flow per mass…”

Section: Methodsmentioning

confidence: 99%

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Investigating the Effect of Ligand Amount and Injected Therapeutic Activity: A Simulation Study for 177Lu-Labeled PSMA-Targeting Peptides

et al. 2016

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In molecular radiotherapy with 177Lu-labeled prostate specific membrane antigen (PSMA) peptides, kidney and/or salivary glands doses limit the activity which can be administered. The aim of this work was to investigate the effect of the ligand amount and injected activity on the tumor-to-normal tissue biologically effective dose (BED) ratio for 177Lu-labeled PSMA peptides. For this retrospective study, a recently developed physiologically based pharmacokinetic model was adapted for PSMA targeting peptides. General physiological parameters were taken from the literature. Individual parameters were fitted to planar gamma camera measurements (177Lu-PSMA I&T) of five patients with metastasizing prostate cancer. Based on the estimated parameters, the pharmacokinetics of tumor, salivary glands, kidneys, total body and red marrow was simulated and time-integrated activity coefficients were calculated for different peptide amounts. Based on these simulations, the absorbed doses and BEDs for normal tissue and tumor were calculated for all activities leading to a maximal tolerable kidney BED of 10 Gy2.5/cycle, a maximal salivary gland absorbed dose of 7.5 Gy/cycle and a maximal red marrow BED of 0.25 Gy15/cycle. The fits yielded coefficients of determination > 0.85, acceptable relative standard errors and low parameter correlations. All estimated parameters were in a physiologically reasonable range. The amounts (for 25−29 nmol) and pertaining activities leading to a maximal tumor dose, considering the defined maximal tolerable doses to organs of risk, were calculated to be 272±253 nmol (452±420 μg) and 7.3±5.1 GBq. Using the actually injected amount (235±155 μg) and the same maximal tolerable doses, the potential improvement for the tumor BED was 1–3 fold. The results suggest that currently given amounts for therapy are in the appropriate order of magnitude for many lesions. However, for lesions with high binding site density or lower perfusion, optimizing the peptide amount and activity might improve the tumor-to-kidney and tumor-to-salivary glands BED ratio considerably.

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Section: Resultsmentioning

confidence: 59%

Section: Methodsmentioning

confidence: 99%

Investigating the Effect of Ligand Amount and Injected Therapeutic Activity: A Simulation Study for 177Lu-Labeled PSMA-Targeting Peptides

et al. 2016

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“…However, due to the potential risks for the development of nephrogenic systemic fibrosis (NSF), the use of gadolinium is considered problematic in transplant recipients with impaired renal function [11]. In recent years, pulsed arterial spin labeling (ASL) techniques have been applied in various anatomical regions for quantification of tissue perfusion without the use of contrast material [12][13][14][15]. The basic approach of ASL techniques is the labeling of arterial blood supplying the tissue of interest by alteration of its longitudinal magnetization.…”

Section: Introductionmentioning

confidence: 99%

Quantification of renal allograft perfusion using arterial spin labeling MRI: initial results

et al. 2009

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“…In recent years, blood flow can be measured with a new magnetic resonance imagery (MRI) technique known as arterial spin labeling (ASL), which does not require the use of contrast agents (2,10,21,24,26). The flow-sensitive alternating inversion recovery (FAIR) of abdominal ASL can be very helpful at reducing background signal and subtraction errors (4,17,27).…”

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confidence: 99%

Arterial spin labeling blood flow magnetic resonance imaging for evaluation of renal injury

Liu

Song

Liang

et al. 2012

American Journal of Physiology-Renal Physiology

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Liu YP, Song R, Liang Ch, Chen X, Liu B. Arterial spin labeling blood flow magnetic resonance imaging for evaluation of renal injury. Am J Physiol Renal Physiol 303: F551-F558, 2012. First published May 30, 2012 doi:10.1152/ajprenal.00288.2011.-A multitude of evidence suggests that iodinated contrast material causes nephrotoxicity; however, there have been no previous studies that use arterial spin labeling (ASL) blood flow functional magnetic resonance imaging (fMRI) to investigate the alterations in effective renal plasma flow between normointensive and hypertensive rats following injection of contrast media. We hypothesized that FAIR-SSFSE arterial spin labeling MRI may enable noninvasive and quantitative assessment of regional renal blood flow abnormalities and correlate with disease severity as assessed by histological methods. Renal blood flow (RBF) values of the cortex and medulla of rat kidneys were obtained from ASL images postprocessed at ADW4.3 workstation 0.3, 24, 48, and 72 h before and after injection of iodinated contrast media (6 ml/kg). The H&E method for morphometric measurements was used to confirm the MRI findings. The RBF values of the outer medulla were lower than those of the cortex and the inner medulla as reported previously. Iodinated contrast media treatment resulted in decreases in RBF in the outer medulla and cortex in spontaneously hypertensive rats (SHR), but only in the outer medulla in normotensive rats. The iodinated contrast agent significantly decreased the RBF value in the outer medulla and the cortex in SHR compared with normotensive rats after injection of the iodinated contrast media. Histological observations of kidney morphology were also consistent with ASL perfusion changes. These results demonstrate that the RBF value can reflect changes of renal perfusion in the cortex and medulla. ASL-MRI is a feasible and accurate method for evaluating nephrotoxic drugs-induced kidney damage.

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MR measurement of blood flow in the parotid gland without contrast medium: a functional study before and after gustatory stimulation

Abstract: ASL FAIR TrueFISP is feasible for functional characterization of the parotid glands. Assessment of changes in blood flow in the parotid gland could serve as a diagnostic tool in patients suffering from xerostomia.

Cited by 19 publications

References 44 publications

Investigating the Effect of Ligand Amount and Injected Therapeutic Activity: A Simulation Study for 177Lu-Labeled PSMA-Targeting Peptides

Investigating the Effect of Ligand Amount and Injected Therapeutic Activity: A Simulation Study for 177Lu-Labeled PSMA-Targeting Peptides

Quantification of renal allograft perfusion using arterial spin labeling MRI: initial results

Arterial spin labeling blood flow magnetic resonance imaging for evaluation of renal injury

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