MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma

Wu, Meiying; Zhang, Haixian; Tie, Changjun; Yan, Chunhong; Deng, Zhiting; Wan, Qian; Liu, Xin; Yan, Fei; Zheng, Hairong

doi:10.1038/s41467-018-07250-6

Cited by 194 publications

(153 citation statements)

References 59 publications

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“…This situation facilitated an environmental-responsive drug release in many solid tumors, thereby reducing the side effect of chemotherapy. [254] ND-MMSNs were developed by core-shell-structured magnetic mesoporous silica NPs (MMSNs) loaded with DOX (D-MMSNs) and were coincubated with neutrophils from the peripheral blood of healthy mice. [250] QDs could provide fluorescence signals for accurate IGS, while SPIONs produced negative-contrast enhancement effects on glioma via MRI and enhanced fluorescence under an external magnetic field.…”

Section: Postoperative Chemotherapymentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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Surgical resection is the primary and most effective treatment for most patients with solid tumors. However, patients suffer from postoperative recurrence and metastasis. In the past years, emerging nanotechnology has led the way to minimally invasive, precision and intelligent oncological surgery after the rapid development of minimally invasive surgical technology. Advanced nanotechnology in the construction of nanomaterials (NMs) for precision imaging-guided surgery (IGS) as well as surgery-assisted synergistic therapy is summarized, thereby unlocking the advantages of nanotechnology in multimodal IGS-assisted precision synergistic cancer therapy. First, mechanisms and principles of NMs to surgical targets are briefly introduced. Multimodal imaging based on molecular imaging technologies provides a practical method to achieve intraoperative visualization with high resolution and deep tissue penetration. Moreover, multifunctional NMs synergize surgery with adjuvant therapy (e.g., chemotherapy, immunotherapy, phototherapy) to eliminate residual lesions. Finally, key issues in the development of ideal theranostic NMs associated with surgical applications and challenges of clinical transformation are discussed to push forward further development of NMs for multimodal IGS-assisted precision synergistic cancer therapy.

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Section: Postoperative Chemotherapymentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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“…Recently, Wu et al incubated a kind of polymorphonuclear leukocyte termed as neutrophils that could travel in blood vessels and congregate in injured, inflamed, or tumor sites ex vivo in a core–shell‐structured ferromagnetic‐particle–mesoporous silica sphere environment . These magnetically labeled neutrophils were then injected into an incomplete resection glioma mouse model, as shown in Figure a.…”

Section: Ferrofluid‐based Detection Diagnosis and Therapymentioning

confidence: 99%

“…b) MRI images showing strong contrast enhancement of tumor sites by magnetically labeled neutrophils. a,b) Reproduced under the terms of the CC‐BY Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/) . Copyright 2018, The Authors, published by Springer Nature.…”

Section: Ferrofluid‐based Detection Diagnosis and Therapymentioning

confidence: 99%

“…Multifunctional Diagnosis and Treatment Platform : Imaging‐guided multifunctional diagnosis and treatment platform could be established by employing ferromagnetic particles as magnetic targeting agents, contrast agents, drug carriers, or heat generation source . To give an example, Wu et al designed thermoresponsive nanoemulsion hydrogel containing ferromagnetic particles for multimodal‐imaging‐guided tumor hyperthermal therapy.…”

Section: Ferrofluid‐based Detection Diagnosis and Therapymentioning

confidence: 99%

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Flexible Ferrofluids: Design and Applications

et al. 2019

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Ferrofluids, also known as ferromagnetic particle suspensions, are materials with an excellent magnetic response, which have attracted increasing interest in both industrial production and scientific research areas. Because of their outstanding features, such as rapid magnetic reaction, flexible flowability, as well as tunable optical and thermal properties, ferrofluids have found applications in various fields, including material science, physics, chemistry, biology, medicine, and engineering. Here, a comprehensive, in‐depth insight into the diverse applications of ferrofluids from material fabrication, droplet manipulation, and biomedicine to energy and machinery is provided. Design of ferrofluid‐related devices, recent developments, as well as present challenges and future prospects are also outlined.

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“…Magnetic resonance imaging (MRI) is widely used for the diagnosis of GBM in clinical practice because of its admirable soft tissue contrast, high spatial resolution, deep tissue penetration, and negligible irradiation damage. Many nanocarriers have been prepared to carry contrast agents across the BBB for the MRI of brain tumors . Nevertheless, most such loaded contrast agents are Fe‐ or Gd‐based, which feature “always‐on” enhancement of MR signals in tumor regions and adjacent normal tissues and are therefore unfavorable for the specific MRI of glioblastoma.…”

Section: Introductionmentioning

confidence: 99%

Intelligent Nanocomposites with Intrinsic Blood–Brain‐Barrier Crossing Ability Designed for Highly Specific MR Imaging and Sonodynamic Therapy of Glioblastoma

Liang

Luo

et al. 2020

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The blood–brain barrier (BBB) is the most important obstacle to improving the clinical outcomes of diagnosis and therapy of glioblastoma. Thus, the development of a novel nanoplatform that can efficiently traverse the BBB and achieve both precise diagnosis and therapy is of great importance. Herein, an intelligent nanoplatform based on holo‐transferrin (holo‐Tf) with in situ growth of MnO2 nanocrystals is constructed via a reformative mild biomineralization process. Furthermore, protoporphyrin (ppIX), acting as a sonosensitizer, is then conjugated into holo‐Tf to obtain MnO2@Tf‐ppIX nanoparticles (TMP). Because of the functional inheritance of holo‐Tf during fabrication, TMP can effectively traverse the BBB for highly specific magnetic resonance (MR) imaging of orthotopic glioblastoma. Clear suppression of tumor growth in a C6 tumor xenograft model is achieved via sonodynamic therapy. Importantly, the experiments also indicate that the TMP nanoplatform has satisfactory biocompatibility and biosafety, which favors potential clinical translation.

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MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma

Cited by 194 publications

References 59 publications

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Flexible Ferrofluids: Design and Applications

Intelligent Nanocomposites with Intrinsic Blood–Brain‐Barrier Crossing Ability Designed for Highly Specific MR Imaging and Sonodynamic Therapy of Glioblastoma

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