MR imaging probes: design and applications

Boros, Eszter; Gale, Eric M.; Caravan, Peter

doi:10.1039/c4dt02958e

Cited by 118 publications

(129 citation statements)

References 154 publications

(266 reference statements)

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“…NHS-PEG (SUN-BRIGHT ME-050AS, Mw: 5000) was purchased from NOF Corporation (Tokyo, Japan). 1 H NMR spectra were recorded at 400 MHz, and 13 C NMR spectra were recorded at 100 MHz with a JEOL EX400. ESI TOF mass spectra were obtained by micrOTOF focus (Bruker Daltonics Co., Billerica, MA).…”

Section: Discussionmentioning

confidence: 99%

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Synthesis and functional evaluation of chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups as highly sensitive MRI contrast agents

et al. 2015

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a b s t r a c tNovel chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups were synthesized and shown to have longitudinal relaxivity (r 1 ) values 5 times higher than that of clinically used Gd-DTPA. The affinities of Gd-4a and Gd-4b for bovine serum albumin (BSA), respectively, were estimated by a quartz crystal microbalance (QCM) measurement. The amino groups of the dendrimer were then conjugated with PEG. This conjugation with PEG strongly affected its ability to attenuate signals in T 1 -weighted MRI.

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Section: Discussionmentioning

confidence: 99%

“…1,2 Low-molecular-weight contrast agents (CAs), such as Gd-DTPA (DTPA¼diethylenetriaminepentaacetic acid) and Gd-DOTA (DOTA¼1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), are widely used in the clinical diagnosis of tumors (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and functional evaluation of chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups as highly sensitive MRI contrast agents

et al. 2015

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“…However, time-consuming processes comprising multiple steps are typically required for the preparation of such multifunctional carriers, which are also very difficult to produce on a large scale. 3,[7][8][9][10] New methods for creating nanoscale theranostic systems are thus much sought after.…”

Section: Introductionmentioning

confidence: 99%

Theranostic Fibers for Simultaneous Imaging and Drug Delivery

Jin

Geraldes

et al. 2016

Mol. Pharmaceutics

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Abstract:New methods for creating theranostic systems with simultaneous encapsulation of therapeutic, diagnostic and targeting agents are much sought after. This work reports for the first time the use of coaxial electrospinning to prepare such systems in the form of core-shell fibers. Eudragit S100 was used to form the shell of the fibers, while the core comprised polyethylene oxide loaded with the magnetic resonance contrast agent Gd(DTPA) (Gd(III) diethylenetriaminepentaacetate hydrate) and indomethacin as a model therapeutic agent. The fibers had linear cylindrical morphologies with clear core-shell structures, as demonstrated by electron microscopy. X-ray diffraction and differential scanning calorimetry proved that both indomethacin and Gd(DTPA) were present in the fibers in the amorphous physical form. This is thought to be a result of intermolecular interactions between the different components, the presence of which was suggested by IR spectroscopy. In vitro dissolution tests indicated that the fibers could provide targeted release of the active ingredients through a combined mechanism of erosion and diffusion. The proton relaxivities for Gd(DTPA) released from the fibers into tris buffer increased (r 1 =5.03-10.13 s -1 mM -1 ; r 2 =8.28-14.96 s -1 mM -1 ) compared with fresh Gd(DTPA) (r 1 =4.37 s -1 mM -1 and r 2 =4.85 s -1 mM -1 ), proving that electrospinning has not diminished the contrast properties of the complex. The new systems reported herein thus offer a new platform for delivering therapeutic and imaging agents simultaneously to the colon.

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“…[21,22] Because the macrocyclic agents are more stable than the linear agents. [23] For this reason, we preferentially choose macrocyclic DOTA as the chelator to construct multinuclear agents.…”

Section: Introductionmentioning

confidence: 99%

Two Binuclear Nonionic Magnetic Resonance Contrast Agents with High Relaxivity

Sun¹,

Li²,

Hong³

et al. 2018

Chin. J. Org. Chem.

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摘要磁共振成像技术被广泛应用于诊断医学和软组织成像, 而磁共振对比剂有助于提高成像对比度. 报道了两种基 Abstract Magnetic resonance imaging (MRI) is widely used in diagnostic medicine and soft tissue imaging. Contrast agents (CAs) can improve the specificity of MRI enhancement. Herein, the design, synthesis and relaxivity of two novel binuclear nonionic Gd-based DOTA-hydrazide derived MRI contrast agents, (Gd-DOTAH) 2 -DYMB and (Gd-DOTAH) 2 -DYMBP are reported. They have improved longitudinal relaxivity values of 11.4 and 11.7 L•mmol -1 •s -1 per molecule or 5.7 and 5.9 L•mmol -1 •Gd -1 •s -1 at 0.5 T, respectively, which are higher than that of the mononuclear clinical macrocyclic agent Gd-DOTA. And in vitro MRI studies suggest the potential of these two agents as MRI contrast agents in improving the diagnostic sensitivity and accuracy.

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MR imaging probes: design and applications

Cited by 118 publications

References 154 publications

Synthesis and functional evaluation of chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups as highly sensitive MRI contrast agents

Synthesis and functional evaluation of chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups as highly sensitive MRI contrast agents

Theranostic Fibers for Simultaneous Imaging and Drug Delivery

Two Binuclear Nonionic Magnetic Resonance Contrast Agents with High Relaxivity

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