MR imaging of the mamillothalamic tract.

Yamada, Kazuo; Shrier, David A.; Rubio, Ana; Yamada, Takashi; Iwanaga, Soji; Shibata, Dean; Patel, Uresh; Numaguchi, Yuji

doi:10.1148/radiology.207.3.9609878

Cited by 26 publications

(19 citation statements)

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“…The primary auditory cortex (27) and the primary somatosensory cortex (28) have been mapped; the appearance of the mammilothalamic tract (29), the microstructural architecture of the corpus callosum (30), and the internal architecture of Ammon's horn (31) have been described; identification of hippocampal layers has been achieved (32). In addition, MR imaging volumetry has been reported using both normal and pathologic postmortem formalin-fixed brains (27,(33)(34)(35).…”

Section: Resultsmentioning

confidence: 99%

Magnetic resonance imaging and mathematical modeling of progressive formalin fixation of the human brain

Yong-Hing

Obenaus

Stryker

et al. 2005

Magnetic Resonance in Med

100

130

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The temporal magnetic resonance (MR) appearance of human brain tissue during formalin fixation was measured and modeled using a diffusion mathematical model of formalin fixation. Coronal MR images of three human brains before formalin fixation and at multiple time points thereafter were acquired. T1 relaxation, T2 relaxation, water apparent diffusion coefficient (ADC), and proton density (PD) maps were calculated. The size of a light "formalin band" region, visible in T1 weighted images, was compared to a mathematical model of diffusive mass transfer of formalin into the brain. T1 relaxation, T2 relaxation, and PD all decreased, in both gray and white matter, as formalin fixation progressed. The ADC remained more or less constant. The location of the inner boundary of the formalin band followed a time course consistent with the steepest formalin concentration gradient in the mathematical model. Based on the diffusion model, the brain is not completely saturated in formalin until after 14.8 weeks of formalin immersion and, based on the observed changes in T1, T2, and PD, fixation is not complete until after 5.4 weeks. During fixation, the ongoing attenuation of T1 relaxation, T2 relaxation, and PD must be taken into consideration when performing postmortem MRI studies.

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Section: Resultsmentioning

confidence: 99%

Magnetic resonance imaging and mathematical modeling of progressive formalin fixation of the human brain

Yong-Hing

Obenaus

Stryker

et al. 2005

Magnetic Resonance in Med

100

130

View full text Add to dashboard Cite

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“…In our series, however, evaluation of the fornices was difficult using the thick axial images. Unilateral mamillary body atrophy can also be seen in patients with mamillothalamic tract degeneration [12]. In our five patients with mamillary body atrophy, the hippocampus fornix mamillary body pathway was thought to be interrupted by infarction of the hippocampal formation, especially the subiculum and/or proximal fornix, because the forniceal fibers originate from the subiculum [13].…”

Section: Discussionmentioning

confidence: 68%

Ipsilateral mamillary body atrophy after infarction of the posterior cerebral artery territory: MR imaging

et al. 2005

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We describe herein magnetic resonance (MR) features of ipsilateral mamillary body atrophy after infarction of the posterior cerebral artery (PCA) territory. During the period May 2000 through July 2004, 13 patients with infarction of the PCA territory underwent cranial MR imaging in the chronic stage. Two 1.5-T scanners were used to obtain axial T1- and T2-weighted images with conventional spin-echo and fast spin-echo pulse sequences, respectively. The slice thickness was 6 mm, with a 2-mm interslice gap. Five of the 13 patients with PCA territory infarction had ipsilateral mamillary body atrophy. However, this asymmetry of the mamillary bodies was unclear in two of the five patients because of the thickness of the axial image slices. All five patients had a temporo-parieto-occipital infarction. The remaining eight patients had a parieto-occipital or an occipital infarction. Unilateral transneuronal mamillary body degeneration after infarction of the ipsilateral PCA territory including the posteromedial temporal lobe can be detected on conventional thick axial MR images.

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“…Furthermore, a subtle, linear hyperintensity along the course of the left mammillo-thalamic tract and a correspondent atrophy of the ipsilateral mammillary body were detected. A recent radiological study analyzed both the normal and abnormal aspects of the mammillo-thalamic tract: in 2 subjects – 1 with an anterior thalamic lesion and another with mesial temporal sclerosis – alterations like those found in our patient were observed and related to a secondary anterograde transneuronal degeneration [15]. Transneuronal or transsynaptic degeneration are the terms used to indicate neuronal alterations caused by the loss of synaptic input when afferent fibers are damaged.…”

Section: Discussionmentioning

confidence: 72%

Subcortical Dementia Associated with Striking Enlargement of the Virchow-Robin Spaces and Transneural Degeneration of the Left Mammillo-Thalamic Tract

et al. 2001

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We report a case of subcortical dementia in a 68-year-old woman. MR examination of the patient’s brain revealed two types of alterations as a possible cause of the dementia, both anomalous in respect of their entity and incidence: the first was a striking enlargement of the Virchow-Robin spaces, and the second an anterograde transneural degeneration of the left mammillo-thalamic tract and mammillary body secondary to a lacunar infarction of the ipsilateral anterior thalamus.

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MR imaging of the mamillothalamic tract.

Abstract: Normal MTTs are readily visible on conventional MR images. Abnormality of the MTT is a very subtle finding but may be a marker of a limbic system abnormality.

Cited by 26 publications

References 0 publications

Magnetic resonance imaging and mathematical modeling of progressive formalin fixation of the human brain

Magnetic resonance imaging and mathematical modeling of progressive formalin fixation of the human brain

Ipsilateral mamillary body atrophy after infarction of the posterior cerebral artery territory: MR imaging

Subcortical Dementia Associated with Striking Enlargement of the Virchow-Robin Spaces and Transneural Degeneration of the Left Mammillo-Thalamic Tract

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