MR imaging of hydrogel filament embolic devices loaded with superparamagnetic iron oxide or gadolinium

Killer, Monika; Keeley, Edward M.; Cruise, Gregory M.; Schmitt, Anne; McCoy, Mark R.

doi:10.1007/s00234-010-0744-z

Cited by 14 publications

(6 citation statements)

References 18 publications

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“…52 Hydrogel filaments containing gadolinium or SPIO were invented to be visualized by MRI and applied to embolization for the treatment of intracranial aneurysm. 53 More precise and accurate mechanical properties such as stiffness and elasticity can be assessed using magnetic resonance elastography (MRE), which uses low-frequency shear wave motion generated by an acoustic actuator coupled to the tissue of interest. The acquired shear wave images can be utilized to assess the mechanical property called the shear elastic modulus, presenting the proportionality relationship between lateral stress and strain in a material.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Imaging Strategies for Tissue Engineering Applications

Nam

Ricles

Suggs

et al. 2015

Tissue Engineering Part B: Reviews

122

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Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Imaging Strategies for Tissue Engineering Applications

Nam

Ricles

Suggs

et al. 2015

Tissue Engineering Part B: Reviews

122

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“…Current embolic materials are either inherent radiopaque or containing an imaging agent. 6 For example, copolymers of acrylate and co-monomers containing iodine are commonly used for embolic materials. [7][8][9][10] However, the preparation of such copolymers is complicated and monomers containing iodine are potentially toxic.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic one-step fabrication of radiopaque alginate microgels with in situ synthesized barium sulfate nanoparticles

Wang

Zhang

et al. 2012

Lab Chip

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In this work, we report a new strategy to fabricate monodispersed radiopaque alginate (Ba-alginate) microgels by a one-step microfluidic method. Alginate droplets containing sulfate ions are first formed by a flow focusing microfluidic setup. These alginate droplets are subsequently solidified by barium ions in a collection bath. During the solidification process, excessive barium ions in the collection bath also react with sulfate ions in the alginate droplet, resulting in barium sulfate (BaSO(4)) nanoparticles in situ synthesized (acting as radiopaque imaging agents) within the Ba-alginate microgels. Scanning electron microscopy (SEM) combined with energy-dispersive X-ray spectroscopy (EDX) illustrate that 800 nm BaSO(4) nanoparticles are uniformly distributed inside the 30 μm Ba-alginate microgels, with 62 wt% of elemental barium (Ba). In addition, X-ray diffraction (XRD) measurements indicate that the BaSO(4) nanoparticles consist of 10 nm in situ synthesized BaSO(4) crystallites. The alginate microgels act as a soft and porous template to prevent the precipitation and aggregation of BaSO(4) nanoparticles. The Ba-alginate microgels are also visible under X-ray radiation. The facile route to fabricate alginate microgels as radiopaque embolic materials is of particular importance for endovascular embolization and localized diagnostic imaging applications. Similar approaches can also be adopted for synthesizing other inorganic nanoparticles in microgels.

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“…Therefore, it is commonly used for the in vivo visualization of hydrogels and evaluation of their degradation over time. [31][32][33][34] The experimental design of this study is shown in Figure 2, panel a. For the injections, the PF-A + AuNPs and PF-A samples were pre-cross-linked using CaCO 3 and D-(+)-gluconic acid 𝛿-lactone (GDL).…”

Section: In Vivo Degradation Of Hydrogelsmentioning

confidence: 99%

Gold‐Enhanced Brachytherapy by a Nanoparticle‐Releasing Hydrogel and 3D‐Printed Subcutaneous Radioactive Implant Approach

Kiseleva

Lescot

Selivanova

et al. 2023

Adv Healthcare Materials

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Brachytherapy (BT) is a widely used clinical procedure for localized cervical cancer treatment. In addition, gold nanoparticles (AuNPs) have been demonstrated as powerful radiosensitizers in BT procedures. Prior to irradiation by a BT device, their delivery to tumors can enhance the radiation effect by generating low‐energy photons and electrons, leading to reactive oxygen species (ROS) production, lethal to cells. No efficient delivery system has been proposed until now for AuNP topical delivery to localized cervical cancer in the context of BT. This article reports an original approach developed to accelerate the preclinical studies of AuNP‐enhanced BT procedures. First, an AuNP‐containing hydrogel (Pluronic F127, alginate) is developed and tested in mice for degradation, AuNP release, and biocompatibility. Then, custom‐made 3D‐printed radioactive BT inserts covered with a AuNP‐containing hydrogel cushion are designed and administered by surgery in mice (HeLa xenografts), which allows for measuring AuNP penetration in tumors (≈100 µm), co‐registered with the presence of ROS produced through the interactions of radiation and AuNPs. Biocompatible AuNPs‐releasing hydrogels could be used in the treatment of cervical cancer prior to BT, with impact on the total amount of radiation needed per BT treatment, which will result in benefits to the preservation of healthy tissues surrounding cancer.

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MR imaging of hydrogel filament embolic devices loaded with superparamagnetic iron oxide or gadolinium

Abstract: Based on these results, we are focusing on loading hydrogel filaments with SPIO in an effort to provide adequate visualisation for use in MR-guided interventions.

Cited by 14 publications

References 18 publications

Imaging Strategies for Tissue Engineering Applications

Imaging Strategies for Tissue Engineering Applications

Microfluidic one-step fabrication of radiopaque alginate microgels with in situ synthesized barium sulfate nanoparticles

Gold‐Enhanced Brachytherapy by a Nanoparticle‐Releasing Hydrogel and 3D‐Printed Subcutaneous Radioactive Implant Approach

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