MR imaging of focal splenic extramedullary hematopoiesis in polycythemia vera: case report

Gabata, Toshifumi; Kadoya, Masumi; Mori, Akira; Kobayashi, Satoshi; Sanada, Junichiro; Matsui, Osamu

doi:10.1007/s002610000045

Cited by 25 publications

(16 citation statements)

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“…While most cases of splenic EMH present as diffuse splenic enlargement, a small percentage present as discrete masses, 1,3,5-7 as in our case. Since the differential diagnosis of discrete splenic lesions also includes lymphoma, angiosarcoma, metastatic disease, hemangioma, lymphangioma and hamartoma, 3 a distinction of EMH from these other le- …”

Section: Discussionmentioning

confidence: 99%

“…However, when EMH forms a discrete mass, it poses a diagnostic dilemma since the differential diagnosis also includes metastatic epithelial malignancy, lymphoma and hemangioma. 1,3 Despite the necessity of histologic confirmation, the role of fine needle aspiration (FNA) remains underrecognized. 1,4 In this context we present a patient with a discrete splenic mass first suggested as EMH by FNA.…”

Section: Background: Extramedullary Hematopoiesis (Emh) Generally Occmentioning

confidence: 99%

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Fine Needle Aspiration of Splenic Extramedullary Hematopoiesis Presenting as a Solitary Mass

Du¹,

Overstreet²,

Wei³

et al. 2002

Acta Cytologica

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Section: Discussionmentioning

confidence: 99%

Section: Background: Extramedullary Hematopoiesis (Emh) Generally Occmentioning

confidence: 99%

Fine Needle Aspiration of Splenic Extramedullary Hematopoiesis Presenting as a Solitary Mass

Du¹,

Overstreet²,

Wei³

et al. 2002

Acta Cytologica

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“…The organs that are involved most frequently are the spleen, liver and lymph nodes. [1][2][3][4] Other organs are involved less frequently; they include the kidney, 5,6 central nervous system, 7,8 lungs, 9 thyroid gland, 10,11 paravertebral region and mediastinum. 12,13 Many theories concerning the pathogenesis of these lesions have been proposed, including the extrusion of bone marrow consequent to bony erosions or fractures, reactivation of hematopoiesis in organs where it previously occurred in embryonic and fetal life, and increased number of circulating hematopoietic stem cells with embolization to different organs.…”

Section: Discussionmentioning

confidence: 99%

“…Most commonly it is secondary to a variety of hematologic disorders, such as myelofibrosis, thalassemia, sickle cell anemia, polycythemia vera, spherocytosis, lymphoma and vitamin B 12 and folate deficiency. EMH often involves the spleen, liver and lymph nodes [1][2][3][4] ; however, other organs, such as the kidney, 5,6 central nervous system, 7,8 lungs, 9 thyroid gland 10,11 and mediastinum, 12,13 are involved less frequently. Theories concerning the pathogenesis of these lesions include reactivation of hematopoietic primitive rests, extrusion of bone marrow consequent to bony le-sions and increased number of circulating hematopoietic stem cells.…”

Section: Background: Extramedullary Hematopoiesis Is a Compensatory Pmentioning

confidence: 99%

Fine Needle Aspiration Diagnosis of Extramedullary Hematopoiesis Resembling Mediastinal and Paravesical Tumors

Sáenz-Santamaría

Catalina-Fernández

2004

Acta Cytologica

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“…As it requires no special instrument and incur no significant trauma and cost to the patient Although radiological modalities like ultrasound, CT scan, or MRI usually narrow down the differential diagnosis but rarely provide a definitive picture and tissue sample in form of an aspirate or a biopsy is required to clinch a specific diagnosis. [9][10][11][12][13][14][15] In these circumstances, FNAC remains the first mainstay diagnostic investigation. Splenic pathology can be localised or secondary to systemic involvement in various diseases.…”

Section: Introductionmentioning

confidence: 99%

Role of aspiration cytology in splenic lesions

2016

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INTRODUCTIONThe FNAC has become quite popular diagnostic modality now days. Splenic fine needle aspiration cytology (FNAC) as a diagnostic procedure has been used since beginning of last century and was first reported in 1916. 1 Although many authors from different centers have highlighted its utility for diagnosing splenic pathology, it is used routinely in very few cases. It has the reputation of being a dangerous intervention and the specimen obtained is usually thought to be unduly difficult to assess, but these prejudicial ideas are fundamentally wrong.2-8 FNAC is a safe, easy, simple, reproducible and rapid diagnostic procedure and has distinct advantage over open true cut or core biopsy. As it requires no special instrument and incur no significant trauma and cost to the patient Although radiological modalities like ultrasound, CT scan, or MRI usually narrow down the differential diagnosis but rarely provide a definitive picture and tissue sample in form of an aspirate or a biopsy is required to clinch a specific diagnosis.9-15 In these circumstances, FNAC remains the first mainstay diagnostic investigation. Splenic pathology can be localised or secondary to systemic involvement in various diseases. The indications of splenic FNAC [3][4][5]8,16 are non- ABSTRACTBackground: Splenic fine needle aspiration cytology (FNAC) as a diagnostic procedure has been used since beginning of last century and was first reported in 1916. The objective of the study was to evaluate the diagnostic role of aspiration cytology in splenic lesions. Methods: In our retrospective study Fine needle aspiration cytology (FNAC) of spleen was done in a total 34 cases, out of which 28 cases were aspirated under ultrasonological guidance and 6 cases were aspirated blindly. There were 23 male and 11 female patients and the age range of the patients was from 2 to 69 years with 8 patients from paediatric group. Before commencing the procedure all the necessary precautions and investigations including coagulation profile were done. Results: Out of 34 FNAC cases, 5 were bloody aspirate while 2 cases showed normal splenic aspirate. In 27 cases definite diagnostic opinion was possible. Amongst non-neoplastic group maximum patients (8 cases) were showing features of extra medullary hematopoeisis followed by 4 cases of tuberculosis, then 3 cases each of kala azar and storage disorder and 2 cases showed granulomas. In the neoplastic group, we had 2 cases of non-Hodgkins lymphoma, one case of Hodgkin lympoma with 2 cases of hairy cell leukemia and one case of histiocytosis. No major difference in the cellularity noticed when the aspiration done blindly or under ultrasound guidance No procedural complications were seen in our study. Conclusion:Hence when done with full precautions FNAC spleen is a safe, cheap, rapid and highly diagnostic procedure as a primary investigation.

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MR imaging of focal splenic extramedullary hematopoiesis in polycythemia vera: case report

Cited by 25 publications

References 0 publications

Fine Needle Aspiration of Splenic Extramedullary Hematopoiesis Presenting as a Solitary Mass

Fine Needle Aspiration of Splenic Extramedullary Hematopoiesis Presenting as a Solitary Mass

Fine Needle Aspiration Diagnosis of Extramedullary Hematopoiesis Resembling Mediastinal and Paravesical Tumors

Role of aspiration cytology in splenic lesions

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