Fine Needle Aspiration of Splenic Extramedullary Hematopoiesis Presenting as a Solitary Mass

Du, Emma Z.; Overstreet, Kerith; Wei, Zhou; Baird, Geoffrey S.; Baird, Stephen M.; Bouvet, Michael; Haghighi, Parviz

doi:10.1159/000327121

Cited by 20 publications

(26 citation statements)

References 8 publications

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“…11,15,27 A diagnosis of extramedullary hematopoesis was cytologically suggested in 2 cases diagnosed as granulomatous inflammation and splenic hamartoma.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic pitfalls in fine needle aspiration biopsy of the spleen

Friedlander

Wei

Iyengar

et al. 2008

Diagnostic Cytopathology

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Fine needle aspiration (FNA) of the spleen is rarely performed, due to fear of procedure complications. The objective of this study is to review the cytologic diagnoses of aspiration biopsy of the spleen performed in a cancer center. Archival material (9-year period) was reviewed and correlated with histologic and ancillary test results, when available.Forty-one splenic FNA specimens were identified. There were no reported procedure complications. Nineteen cases were diagnosed as malignant. Of these, 11 were lymphomas. Nineteen cases were diagnosed as benign. There was one false-negative case and four false-positive cases. Primary splenic neoplasms were rare and misinterpreted as malignant. It is important to be familiar with the normal cytology of this uncommonly aspirated organ in order to successfully identify neoplastic and malignant processes. The use of ancillary studies is important in the definitive classification of benign and malignant splenic lesions.

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“…11,15,27 A diagnosis of extramedullary hematopoesis was cytologically suggested in 2 cases diagnosed as granulomatous inflammation and splenic hamartoma.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic pitfalls in fine needle aspiration biopsy of the spleen

Friedlander

Wei

Iyengar

et al. 2008

Diagnostic Cytopathology

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“…EMH is usually related to ineffective hematopoiesis in the bone marrow, most commonly seen in chronic myeloproliferative disorders (primary myelofibrosis/agnogenic myeloid metaplasia, polycythemia vera, essential thrombocythemia and chronic myelogenous leukemia), myelodysplasia, hemoglobinopathies (the most common are thalassemia and sickle-cell anemia) and myelophthisic anemia caused by bone marrow infiltration by metastatic carcinoma [7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26]. EMH has also been rarely identified in unexpected settings such as in mechanical valves [4] and myocardial infarction [27].…”

Section: Discussionmentioning

confidence: 99%

Extramedullary Hematopoiesis: Cytomorphologic, Histologic, and Radiologic Findings in Sixteen Cases

Sheikh

Rodić

Maleki³

2015

Acta Cytologica

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Background: We report a case series of extramedullary hematopoiesis (EMH) diagnosed from the fine needle aspiration (FNA) procedure. Unanticipated EMH is a markedly rare diagnosis that typically presents as a solitary mass of undetermined significance. As such, knowledge of cytopathologic characteristics as well as clinical and radiologic correlates of EMH is paramount. Method and Material: A total of 16 EMH cytopathologic cases were seen at the Johns Hopkins Hospital in the past 22 years. Results: Median age at diagnosis was 61 years and there was no gender bias (male-to-female ratio: 1:1). Presenting signs and symptoms varied widely, from incidental radiographic findings to hemiparesis. Likewise, presumptive clinical diagnoses in 11 of the 16 cases were benign and the other 5 were considered malignant prior to the diagnostic FNA. The most common anatomic site for EMH was the liver, followed by the presacral soft tissue and pleura. While most EMH nodules were singular, a few presented with as many as three radiographically distinct nodules. The average EMH nodule measured 2.8 cm; the EMH liver nodules were larger and measured 4.3 cm on average (p = 0.0043). Conclusion: We share here the salient clinical and radiologic findings and the diagnostic cytopathologic features of EMH in an effort to familiarize the pathologist/cytotechnologist community with this fascinating albeit rare entity.

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“…La biopsia percutánea o la PAAF pueden ser suficientes para tal efecto, permitiendo una mejor planificación prequirúrgica o indicando un manejo clínico más adecuado incluso evitando la excisión quirúrgica, con la excepción de las lesiones sintomá-ticas o diagnósticos dudosos 11,23,24 . En nuestro caso, al tratarse de un hallazgo incidental sin clínica asociada se podría haber obviado la cirugía con un diagnóstico percutáneo previo.…”

Section: Discussionunclassified

Mielolipoma extraadrenal retroperitoneal

Martínez

González

2009

Actas Urol Esp

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Extraadrenal myelolipomas are rare benign tumors and differentiating them from other soft tissue tumors containing fat can be difficult. A retroperitoneal myelolipoma adjacent to right renal helium is presented in this case-report. Initially oriented as liposarcoma, the final diagnosis was obtained after surgery. Computed tomography (CT), ultrasound (US) and magnetic resonance imaging (MRI) features may vary according to the major component of the tumor. MRI with fat suppression and opposed-phase imaging are the best imaging tools to demonstrate the adipose tissue. A histological confirmation may allow a better presurgical planification in most cases.

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Fine Needle Aspiration of Splenic Extramedullary Hematopoiesis Presenting as a Solitary Mass

Cited by 20 publications

References 8 publications

Diagnostic pitfalls in fine needle aspiration biopsy of the spleen

Diagnostic pitfalls in fine needle aspiration biopsy of the spleen

Extramedullary Hematopoiesis: Cytomorphologic, Histologic, and Radiologic Findings in Sixteen Cases

Mielolipoma extraadrenal retroperitoneal

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