MR imaging of Creutzfeldt-Jakob disease.

Finkenstaedt, Michael; Szudra, Annemarie; Zerr, Inga; Poser, S.; Hise, Joseph; Stoebner, J M; Weber, Thomas K.

doi:10.1148/radiology.199.3.8638007

Cited by 178 publications

(93 citation statements)

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“…Interestingly, we found no evidence for BBB impairment in scrapie-inoculated BM chimeric mice at any time point, which is in line with previous reports excluding BBB leakage in tga20 and wild-type mice with clinical symptoms of scrapie (Eikelenboom et al, 1987;Brandner et al, 1998). Magnetic resonance imaging studies of patients with CJD revealed T2-hyperintensities without significant BBB disruption (Yoon et al, 1995;Finkenstaedt et al, 1996). However, some studies did report patchy BBB leakage in scrapie (Wisniewski et al, 1983;Chung et al, 1995), particularly in the cerebellum (Vorbrodt et al, 1997).…”

Section: Absence Of Prion Replication In Microgliasupporting

confidence: 91%

Early and Rapid Engraftment of Bone Marrow-Derived Microglia in Scrapie

Priller

Prinz²,

Heikenwälder³

et al. 2006

J. Neurosci.

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Prion neuroinvasion is accompanied by maximal activation of microglia, the significance of which for pathogenesis is unknown. Here, we used bone marrow (BM) cells expressing GFP (green fluorescent protein) to study the turnover of microglia in mouse scrapie. We found that Ն50% of all brain microglia were replaced by BM-derived cells before clinical disease onset. In terminally sick mice, microglia density increased threefold to fourfold. Hence BM-derived microglia rapidly and efficaciously colonize the brain in scrapie.

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Section: Absence Of Prion Replication In Microgliasupporting

confidence: 91%

Early and Rapid Engraftment of Bone Marrow-Derived Microglia in Scrapie

Priller

Prinz²,

Heikenwälder³

et al. 2006

J. Neurosci.

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“…Sie zeichnet sich jedoch als sensitive (67%) und hoch spezifische (93%) diagnostische Zusatzuntersuchung aus (Schröter et al 2000). Typisch für die sCJK sind bilaterale symmetrische hyperintense Basalganglien sowie Signalanhebungen im Kortex und Thalamus, die vor allem in der Diffusions-und Protonen-Dichte-Wichtung, aber auch in der T2-und FLAIR-Wichtung ("Fluid-Attenuated-Inversion-Recovery") sichtbar werden (Finkenstaedt et al 1996, Schröter et al 2000, Kallenberg et al 2006). …”

Section: Magnetresonanztomografieunclassified

Risikofaktoren der sporadischen Creutzfeldt-Jakob-Krankheit

Kittner

Heinemann

Zerr

2009

Dtsch med Wochenschr

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“…However, this test is unreliable as a stand-alone diagnostic of vCJD and is impractical for use with ruminants. Magnetic resonance imaging (MRI) has also been applied to the study of patients with variant and sporadic CJD but no consistent diagnostic differences between the experimental groups was observed [28,107], although the bilateral pulvinar high signal had been shown to be of potential utility in the confirmation of CJD [129]. However, although MRI is non-invasive, it is expensive and impractical to use with animals.…”

Section: Electrophysiological Markers and Imagingmentioning

confidence: 99%

The use of non-prion biomarkers for the diagnosis of Transmissible Spongiform Encephalopathies in the live animal

Parveen

Moorby²,

Allison³

et al. 2005

Vet. Res.

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-Scrapie and bovine spongiform encephalopathy (BSE) are major global concerns and the emergence of variant Creutzfeldt-Jakob disease (vCJD) has caused turmoil for blood transfusion services and hospitals worldwide. Recent reports of iatrogenic CJD (iCJD) cases following blood transfusions from Transmissible Spongiform Encephalopathies (TSE)-infected donors have fuelled this concern. Major diagnostic tests for BSE and scrapie are conducted post-mortem from animals in late stages of the disease. Although the lymphoreticular system is involved in the earlier pathogenesis of some forms of sheep scrapie and vCJD, which presents great opportunity for diagnostic development, other TSE diseases (some strains of scrapie, sporadic CJD (sCJD) and bovine BSE) do not present such a diagnostic opportunity. Thus, there is an urgent need for premortem tests that differentiate between healthy and diseased individuals at early stages of illness, in accessible samples such as blood and urine using less invasive procedures. This review reports on the current state of progress in the development and use of prion and non-prion biomarkers in the diagnosis of TSE diseases. Some of these efforts have concentrated on improving the sensitivity of PrP Sc detection to allow in vivo diagnosis at low abundances of PrP Sc whilst others have sought to identify non-prion protein biomarkers of TSE disease, many of which are still at early stages of development. In this review we comment upon the limitations of prion based tests and review current research on the development of tests for TSE that rely on non-prion disease markers in body fluids that may allow preclinical disease diagnosis.

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MR imaging of Creutzfeldt-Jakob disease.

Cited by 178 publications

References 0 publications

Early and Rapid Engraftment of Bone Marrow-Derived Microglia in Scrapie

Early and Rapid Engraftment of Bone Marrow-Derived Microglia in Scrapie

Risikofaktoren der sporadischen Creutzfeldt-Jakob-Krankheit

The use of non-prion biomarkers for the diagnosis of Transmissible Spongiform Encephalopathies in the live animal

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