MR Clean-Med -- The Effect of Periprocedural Medication in Patients Undergoing Intra-Arterial Treatment for Acute Ischemic Stroke: Heparin, Antiplatelet Agents, Both or Neither

Graaf, Rob van de

doi:10.26226/morressier.5aeac941521e300021137fe6

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“…In the 4th safety report, the DSMB advised to further evaluate the efficacy and safety of the moderate-dose UFH arm, which will be compared to the blinded data of the other arms. Results from this analysis have been reported on scientific meetings and will be submitted for publication [49,50]. On May 31, 2020, a total of 5 Dutch and 5 French sites agreed to participate in MR CLEAN MED, and 441 patients were included in the trial by 13 enrolling centers.…”

Section: Trial Statusmentioning

confidence: 99%

Multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke. The effect of periprocedural medication: acetylsalicylic acid, unfractionated heparin, both, or neither (MR CLEAN-MED). Rationale and study design

Chalos

Graaf

Roozenbeek

et al. 2020

Trials

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Background: Despite evidence of a quite large beneficial effect of endovascular treatment (EVT) for ischemic stroke caused by anterior circulation large vessel occlusion, many patients do not recover even after complete recanalization. To some extent, this may be attributable to incomplete microvascular reperfusion, which can possibly be improved by antiplatelet agents and heparin. It is unknown whether periprocedural antithrombotic medication in patients treated with EVT improves functional outcome. The aim of this study is to assess the effect of acetylsalicylic acid (ASA) and unfractionated heparin (UFH), alone, or in combination, given to patients with an ischemic stroke caused by an intracranial large vessel occlusion in the anterior circulation during EVT.

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Section: Trial Statusmentioning

confidence: 99%