MR‐based motion correction for PET imaging using wired active MR microcoils in simultaneous PET‐MR: Phantom study

Huang, Chuan; Ackerman, Jerome L.; Petibon, Yoann; Brady, Thomas J.; Fakhri, Georges El; Ouyang, Jinsong

doi:10.1118/1.4868457

Cited by 30 publications

(25 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, since the same bias affects all reconstructed volumes, the comparison between reconstruction methods and the conclusions drawn in this work remain valid. In order to include the surface coil in the overall attenuation map, several MR markers such as wired or wireless micro coils (Huang et al ., 2014b; Huang et al ., 2014a), can be attached to the surface coil to track its location and shape during the acquisition.…”

Section: Discussionmentioning

confidence: 99%

Impact of motion and partial volume effects correction on PET myocardial perfusion imaging using simultaneous PET-MR

et al. 2016

Self Cite

View full text Add to dashboard Cite

PET is an established modality for myocardial perfusion imaging (MPI) which enables quantification of absolute myocardial blood flow (MBF) using dynamic imaging and kinetic modeling. However, heart motion and Partial Volume Effects (PVE) significantly limit the spatial resolution and quantitative accuracy of PET MPI. Simultaneous PET-MR offers a solution to the motion problem in PET by enabling MR-based motion correction of PET data. The aim of this study was to develop a motion and PVE correction methodology for PET MPI using simultaneous PET-MR, and to assess its impact on both static and dynamic PET MPI using 18F-Flurpiridaz, a novel 18F-labeled perfusion tracer. Two dynamic 18F-Flurpiridaz MPI scans were performed on healthy pigs using a PET-MR scanner. Cardiac motion was tracked using a dedicated tagged-MRI (tMR) sequence. Motion fields were estimated using non-rigid registration of tMR images and used to calculate motion-dependent attenuation maps. Motion correction of PET data was achieved by incorporating tMR-based motion fields and motion-dependent attenuation coefficients into image reconstruction. Dynamic and static PET datasets were created for each scan. Each dataset was reconstructed as (i) Ungated, (ii) Gated (end-diastolic phase), and (iii) Motion-Corrected (MoCo), each without and with point spread function (PSF) modeling for PVE correction. Myocardium-to-blood concentration ratios (MBR) and apparent wall thickness were calculated to assess image quality for static MPI. For dynamic MPI, segment- and voxel-wise myocardial blood flow (MBF) values were estimated by non-linear fitting of a 2-tissue compartment model to tissue time-activity-curves. MoCo and Gating respectively decreased mean apparent wall thickness by 15.1% and 14.4% and increased MBR by 20.3% and 13.6% compared to Ungated images (P<0.01). Combined motion and PSF correction (MoCo-PSF) yielded 30.9% (15.7%) lower wall thickness and 82.2% (20.5%) higher MBR compared to Ungated data reconstructed without (with) PSF modeling (P<0.01). For dynamic PET, mean MBF across all segments were comparable for MoCo (0.72±0.21 mL/min/mL) and Gating (0.69±0.18 mL/min/mL). Ungated data yielded significantly lower mean MBF (0.59±0.16 mL/min/mL). Mean MBF for MoCo-PSF was 0.80±0.22 mL/min/mL, which was 37.9% (25.0%) higher than that obtained from Ungated data without (with) PSF correction (P<0.01). The developed methodology holds promise to improve the image quality and sensitivity of PET MPI studies performed using PET-MR.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of motion and partial volume effects correction on PET myocardial perfusion imaging using simultaneous PET-MR

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Due to the advent of simultaneous MR/PET devices, techniques involving the use of MR images for motion correction of PET images have also been introduced [24,25]. Although implementation and results are shown for PMC enabled MRI, the algorithms presented for detection of squints for marker based tracking systems could provide valuable information for retrospective motion correction techniques of PET images as well.…”

Section: Discussionmentioning

confidence: 99%

Optical tracking with two markers for robust prospective motion correction for brain imaging

Singh

Zahneisen

Keating

et al. 2015

Magn Reson Mater Phy

View full text Add to dashboard Cite

Object Prospective motion correction (PMC) during brain imaging using camera-based tracking of a skin-attached marker may suffer from problems including loss of marker visibility due to the coil and false correction due to non-rigid-body facial motion, such as frowning or squinting. A modified PMC system is introduced to mitigate these problems and increase the robustness of motion correction. Materials and Methods The method relies on simultaneously tracking two markers, each providing six degrees of freedom, that are placed on the forehead. This allows us to track head motion when one marker is obscured, and detect skin movements to prevent false corrections. Experiments were performed to compare the performance of the two-marker motion correction technique to the previous single-marker approach. Results Experiments validate the theory developed for adaptive marker tracking and skin movement detection, and demonstrate improved image quality during obstruction of the line-of-sight of one marker, when subjects squint, or when subjects squint and move simultaneously. Conclusion The proposed methods eliminate two common failure modes of PMC and substantially improve the robustness of PMC and can be applied to other optical tracking systems capable of tracking multiple markers. The methods presented can be adapted to the use of more than two markers.

show abstract

“…This is unfortunately the case for today’s PET-MR scanners because surface coils may move during the scan and incorporating time-dependent attenuation of the surface coils is challenging. One solution is to attach multiple MR markers, such as tracking coils [43, 44] or vitamin E capsules, to the surface coils. The locations of these markers can be identified so that an accurate time-dependent coil attenuation map can be accounted for in PET AC.…”

Section: Resultsmentioning

confidence: 99%

Quantitative simultaneous positron emission tomography and magnetic resonance imaging

et al. 2014

Self Cite

View full text Add to dashboard Cite

Abstract. Simultaneous positron emission tomography and magnetic resonance imaging (PET-MR) is an innovative and promising imaging modality that is generating substantial interest in the medical imaging community, while offering many challenges and opportunities. In this study, we investigated whether MR surface coils need to be accounted for in PET attenuation correction. Furthermore, we integrated motion correction, attenuation correction, and point spread function modeling into a single PET reconstruction framework. We applied our reconstruction framework to in vivo animal and patient PET-MR studies. We have demonstrated that our approach greatly improved PET image quality.

show abstract

MR‐based motion correction for PET imaging using wired active MR microcoils in simultaneous PET‐MR: Phantom study

Cited by 30 publications

References 35 publications

Impact of motion and partial volume effects correction on PET myocardial perfusion imaging using simultaneous PET-MR

Impact of motion and partial volume effects correction on PET myocardial perfusion imaging using simultaneous PET-MR

Optical tracking with two markers for robust prospective motion correction for brain imaging

Quantitative simultaneous positron emission tomography and magnetic resonance imaging

Contact Info

Product

Resources

About