MR assessment of regional myocardial mechanics

Simpson, Robin; Keegan, Jennifer; Firmin, David N.

doi:10.1002/jmri.23756

Cited by 78 publications

(67 citation statements)

References 164 publications

(297 reference statements)

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“…The strain analysis obtained from the reconstructed images agreed well with historical strain values (35) (Figure 4.9). These preliminary results suggest that acceleration will make it feasible to routinely employ 3D cine DENSE for clinical comprehensive myocardial strain imaging with scan times of around 3 minutes.…”

Section: Accelerated 3d Cine Densesupporting

confidence: 78%

“…has emerged as a strain imaging technique that, compared to tagging, has equivalent accuracy and better reproducibility (39), and where strain analysis is less time consuming (35,40,41).…”

Section: Cine Displacement Encoding With Stimulated Echoes (Dense)mentioning

confidence: 99%

“…Circumferential strain (Ecc) is the most commonly reported strain element (35) and was selected in this study to evaluate the reconstruction algorithms. To limit user-dependent variability, different reconstructions of the same prospectively or retrospectively accelerated data used the same initially defined contours.…”

Section: Functional Analysismentioning

confidence: 99%

“…MRI myocardial tagging, a long-established method, has been considered the gold standard as compared to strain imaging using echocardiography (34,35). However, recently within the MRI modality, cine displacement encoding with stimulated echoes (DENSE) (36-38)…”

Section: Introductionmentioning

confidence: 99%

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Accelerated Dynamic Cardiac MRI Using Motion-Guided Compressed Sensing with Regional Sparsity

Chen

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All rights reserved AbstractDynamic cardiac Magnetic Resonance Imaging (CMR) demands fast imaging techniques to obtain high spatial-resolution, large spatial-coverage and high temporal-resolution images for accurate prognosis and diagnosis. Compressed sensing (CS), a fast imaging technique of growing importance, is making a major impact on MRI. Using CS, high-quality images can be recovered from data sampled well below the Nyquist rate. Because of the high temporal and spatial redundancy inherent to dynamic images, these data are well-suited for acceleration by CS.However, the complex dynamics which include both object motions and image contrast variations encountered in dynamic CMR pose challenging tasks for CS techniques. The complexity, if not handled correctly, leads to largely degraded reconstruction quality.This dissertation presents a novel CS method to accelerate dynamic CMR imaging, especially those with complex dynamics, with a motion-compensated CS method that exploits regional spatiotemporal sparsity: Block LOw-rank Sparsity with Motion-guidance (BLOSM). In one iteration of the BLOSM calculation, blocks of image pixels are motion-tracked through time and low-rank sparsity is exploited within the tracked blocks. The de-noised blocks are merged back into complete images and compensated for data fidelity.The BLOSM method was first developed and validated using retrospectively accelerated first-pass cardiac perfusion images with prominent respiratory motion and computer simulated motion phantoms. Systematic experiments were conducted to compare BLOSM to several other II competing CS methods. The BLOSM showed great quality improvement for the images presenting complex dynamics.Two CMR applications of great clinical importance, both of which present distinct and extremely challenging tasks for CS, were prospectively accelerated using BLOSM.First-pass cardiac perfusion imaging was accelerated on patients with suspected heart disease. With prospective rate 4 acceleration, multi-slice high spatial resolution perfusion images were acquired. A Poisson-disc-distributed sampling pattern was implemented. BLOSM was extended to incorporate parallel imaging. The image quality offered by BLOSM showed significant improvement over the other CS methods when respiratory motion occurred.2D cine DENSE imaging was accelerated using BLOSM. The scan time was shortened from two separate breathholds of total 28 heartbeats to one single breathhold of 8 heartbeats.Variable-density spiral trajectory with golden angle rotation was designed for accelerated data sampling. Both retrospective and prospective studies were conducted in healthy volunteers and BLOSM provided high image quality and the cardiac function assessed from BLOSM reconstructed images matched well with the fully-sampled reference data.III

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Section: Accelerated 3d Cine Densesupporting

confidence: 78%

“…has emerged as a strain imaging technique that, compared to tagging, has equivalent accuracy and better reproducibility (39), and where strain analysis is less time consuming (35,40,41).…”

Section: Cine Displacement Encoding With Stimulated Echoes (Dense)mentioning

confidence: 99%

Section: Functional Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Accelerated Dynamic Cardiac MRI Using Motion-Guided Compressed Sensing with Regional Sparsity

Chen

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“…DENSE has an inherently low signal-to-noise ratio. 30,37 This technique has been shown to be useful in the assessment of subjects with acute myocardial infarction and ventricular dyssynchrony. 38 SENC is a relatively new method in which the tag planes are oriented parallel to the imaging plane.…”

Section: D and 3d Echocardiographymentioning

confidence: 99%

New Imaging-Based Tools for the Assessment of Ventricular Function in Ischemic Heart Diseases

Bordi¹,

Kovács²,

Bajka³

et al. 2017

Journal of Interdisciplinary Medicine

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Ischemic heart disease morbidity and mortality are closely related to global and regional left ventricular function. The evaluation of left ventricular global function is a relevant part in the evolution of ischemic heart disease because it plays a significant role in prognosis prediction and patient management after revascularization. Regional function is also a critical part of the evolution, offering a possible and reliable mode for the assessment of myocardial disease. Currently several techniques for the evaluation of left ventricular parameters and function are in use. In this review we will discuss and compare currently available methods for the evaluation of global and regional left ventricular function such as 2D and 3D echocardiography, 3D speckle-tracking echocardiography, multi-slice computed tomography, and cardiac magnetic resonance imaging.Keywords: ischemic heart disease, echocardiography, 3D speckle-tracking echocardiography, multi-slice computed tomography, cardiac magnetic resonance imaging REVIEW DOI: 10.1515/jim-2017-0020 CARDIOLOGY // IMAGING Ischemic heart disease is the leading cause of death around the world. The morbidity and mortality rates are closely associated to regional and global left ventricular function in these patients. 1,2 The evaluation of global left ventricular (LV) function with noninvasive imaging tools has an important role in the therapeutic management and prognosis of patients with ischemic cardiac diseases. Several parameters have been proposed as illustrative for global left ventricular function such as volumes, ejection fraction, dimensions, end-diastolic pressure, contractility, and deformation parameters. Global systolic function is most often evaluated by measuring the difference in the end-diastolic and end-systolic volumes, determined in one, two and three dimensions, divided by the adequate end-diastolic volume. 3 Echocardiography is the most frequently used noninvasive technique for the analysis of LV parameters and function because of its accessibility, portability, and widely validated scale.

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Quantitative 3D X‐ray Imaging of Densification, Delamination and Fracture in a Micro‐Composite under Compression

et al. 2015

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Phase-contrast three-dimensional tomograms showing in unprecedented detail the mechanical response of a micro-composite subjected to a mechanical compression test are reported. The X-ray ptychography images reveal the deformation and fracture processes of a 10 m diameter composite, consisting of a spherical polymer bead coated with a nominally 210 nm metal shell. The beginning delamination of the shell from the core can be directly observed 2 already at an engineering strain of a few percent. Pre-existing defects are shown to dictate the deformation behavior of both core and shell. The strain state of the increasingly compressed polymer core is assessed quantitatively through the local densification at sub-micron resolution, supported by finite element analysis. Nanoscale mechanics is of rapidly growing importance in materials science, biotechnology and medicine, and this study demonstrates the use of coherent X-ray microscopy as a powerful tool for in situ studies of the mechanical properties of nanostructured devices, structures and composites.

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MR assessment of regional myocardial mechanics

Cited by 78 publications

References 164 publications

Accelerated Dynamic Cardiac MRI Using Motion-Guided Compressed Sensing with Regional Sparsity

Accelerated Dynamic Cardiac MRI Using Motion-Guided Compressed Sensing with Regional Sparsity

New Imaging-Based Tools for the Assessment of Ventricular Function in Ischemic Heart Diseases

Quantitative 3D X‐ray Imaging of Densification, Delamination and Fracture in a Micro‐Composite under Compression

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