MR angiography of the pedal arteries with gadobenate dimeglumine, a contrast agent with increased relaxivity, and comparison with selective intraarterial DSA

Kreitner, Karl‐Friedrich; Kunz, R. P.; Herber, Silvani; Martenstein, Sonja; Dorweiler, Bernhard; Dueber, Christoph

doi:10.1002/jmri.21226

Cited by 32 publications

(13 citation statements)

References 40 publications

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“…10 MRA delineated significantly more patent pedal vessels without segmental occlusion and more metatarsal arteries than selective DSA, but unlike our study, nearly half of the cohort merely suffered from moderate claudication. However, as previously shown, higher temporal resolution in conjunction with higher spatial resolu- tion is warranted and may be especially helpful in patients with more severe PAOD and DM.…”

Section: Discussioncontrasting

confidence: 79%

Unmasking pedal arteries in patients with critical ischemia using time-resolved contrast-enhanced 3D MRA

Langer

Krämer

Mommertz

et al. 2009

Journal of Vascular Surgery

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Section: Discussioncontrasting

confidence: 79%

Unmasking pedal arteries in patients with critical ischemia using time-resolved contrast-enhanced 3D MRA

Langer

Krämer

Mommertz

et al. 2009

Journal of Vascular Surgery

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“…All the five foot arteries had a high percentage of diagnostic segments and excellent image quality in both healthy volunteers and diabetic patients, especially the two main foot arteries, the dorsal artery and lateral plantar artery. The average number of diagnostic segments of the two arteries on NCE-MRA was over 95%, which is similar to the results reported using time-resolved or dedicated single station CE-MRA of the foot in the previous studies [7, 12, 33]. Meanwhile, although the flow of the pedal arteries may be impaired in the context of diabetes, the NCE-MRA technique yielded similar percentage of diagnostic arterial segments in both healthy volunteers and diabetic patients (303/320=95% v.s.…”

Section: Discussionsupporting

confidence: 88%

Unenhanced MR Angiography of the Foot: Initial Experience of Using Flow-Sensitive Dephasing–prepared Steady-State Free Precession in Patients with Diabetes

Liu¹,

Fan²,

Zhang³

et al. 2014

Radiology

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Purpose To assess image quality and diagnostic performance of non-contrast enhanced MR angiography (NCE-MRA) using flow-sensitive dephasing (FSD) prepared steady-state free precession (SSFP) for the foot arteries in patients with diabetes. Materials and Methods This prospective study was approved by institutional review board and informed consent was obtained from all subjects. Thirty-two healthy volunteers and 38 diabetic patients who had been scheduled for lower extremity contrast-enhanced MRA (CE-MRA) were recruited for the NCE-MRA study on a 1.5T MR system. Image quality and diagnostic accuracy of NCE-MRA for detecting significant arterial stenosis (≥50%) were assessed by two independent reviewers using CE-MRA as reference standard. The difference of the percentage of diagnostic arterial segments on NCE-MRA between healthy volunteers and diabetic patient was evaluated using McNemar test and Generalized Estimating Equation (GEE) for correlated data. Signal-to-noise ratio (SNR) and artery-to-muscle contrast-to-noise ratio (CNR) of pedal arteries were measured and compared between the two MRA techniques using paired t-test. Results All subjects successfully underwent NCE-MRA of the foot. NCE-MRA yielded a high percentage of diagnostic arterial segments obtained in both healthy volunteers (303/320=95%) and patients (341/370=92%) and there was no difference in the percentage between the two populations (p=0.195). In patients, the average SNR, and CNR on NCE-MRA was higher than those on CE-MRA (90.7± 38.1 vs. 81.7± 34.7, p=0.023, and 85.2 ± 33.2 vs. 76.6 ± 33.5, p=0.013, respectively.). The average sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of NCE-MRA were 35/40=88%, 107/115=93%, 35/43=81%, 107/112=96%, and 142/155=92%, respectively. Interobserver agreement between the two readers for diagnostic accuracy was good (k = 0.83). Conclusion NCE-MRA using FSD-prepared SSFP allows clear depiction of the foot arterial tree and accurate detection of significant arterial stenosis. The technique has the potential to be a safe and reliable screening tool for the assessment of foot arteries in diabetic patients without using gadolinium-based contrast agent.

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“…Because it is taken up by functioning hepatocytes and excreted in bile, use of gadobenate dimeglumine results in marked and prolonged enhancement of normal liver parenchyma for as long as 2 hours on T1-weighted images with minimal or no enhancement of nonhepatocellular tumors, improving the utility of MRI in characterizing focal liver lesions [21][22][23]. In addition, several studies have shown successful use of gadobenate dimeglumine in MR angiography of a variety of vascular territories and in MRI of the brain [24][25][26].…”

Section: Choi Et Almentioning

confidence: 99%

Hepatocellular Carcinoma in Liver Transplantation Candidates: Detection with Gadobenate Dimeglumine–Enhanced MRI

Choi

Lee

et al. 2008

American Journal of Roentgenology

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529sis determines patient eligibility for and the potential success of curative treatments. Therefore, CT and MRI aided by technologic advances that afford improved spatial, temporal, and contrast resolution are regarded as promising alternative surveillance tools for detecting HCC [4,5]. Contrast-enhanced dynamic multiphasic imaging has substantial performance benefits because most HCCs are hypervascular lesions that typically become enhanced during the hepatic arterydominant phase of imaging [6]. OBJECTIVE. The purpose of this study was to retrospectively evaluate the diagnostic performance of dynamic gadobenate dimeglumine-enhanced MRI with explant pathologic correlation in the detection of hepatocellular carcinoma (HCC) in patients undergoing liver transplantation. Hepatocellular Carcinoma in H e p a t o b i l i a r y I m ag i ng • O r ig i n a l R e s e a rc hMATERIALS AND METHODS. Forty-seven patients (28 men, 19 women; mean age, 49 years) underwent dynamic gadobenate dimeglumine-enhanced MRI within 3 months before primary liver transplantation. Dynamic imaging was performed before (unenhanced) and after (hepatic arterial, portal venous, equilibrium, and 1-hour delayed phases) IV bolus administration of gadobenate dimeglumine at 0.1 mmol/kg body weight. Retrospective image analysis to detect HCC nodules was performed independently by two abdominal radiologists who had no pathologic information. On a per-nodule basis, the sensitivity and positive predictive value were calculated for the two observers. Sensitivity and specificity in the diagnosis of HCC also were evaluated. Fisher's exact test was performed to determine whether there was a detection difference between HCC nodules 1 cm in diameter or larger and nodules smaller than 1 cm and to evaluate the differences in causes of false-positive MRI findings based on lesion size (≥ 1 cm vs < 1 cm).RESULTS. Twenty-seven patients had 41 HCCs. In HCC detection, gadobenate dimeglumine-enhanced MRI had a sensitivity of 85% (35 of 41 HCCs) and a positive predictive value of 66% (35 of 53 readings) for observer 1 and a sensitivity of 80% (33 of 41 HCCs) and a positive predictive value of 65% (34 of 52 readings) for observer 2. For both observers, sensitivity in the detection of HCCs 1 cm in diameter and larger (91-94%) was significantly different (p < 0.05) from that in detection of HCCs smaller than 1 cm (29-43%). Nonneoplastic arterial hypervascular lesions more often caused false-positive diagnoses of lesions smaller than 1 cm in diameter (80-86%) on MR images than of those 1 cm in diameter and larger (0-25%). The difference was statistically significant (p < 0.05) for both observers. In diagnosis, gadobenate dimeglumine-enhanced MRI had a sensitivity of 87% (20 of 23 patients) and a specificity of 79% (19 of 24 patients) for both observers.CONCLUSION. Dynamic gadobenate dimeglumine-enhanced MRI has a sensitivity of 80-85% and a positive predictive value of 65-66% in the detection of HCC. The technique, however, is of limited value for detecting and characterizi...

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MR angiography of the pedal arteries with gadobenate dimeglumine, a contrast agent with increased relaxivity, and comparison with selective intraarterial DSA

Cited by 32 publications

References 40 publications

Unmasking pedal arteries in patients with critical ischemia using time-resolved contrast-enhanced 3D MRA

Unmasking pedal arteries in patients with critical ischemia using time-resolved contrast-enhanced 3D MRA

Unenhanced MR Angiography of the Foot: Initial Experience of Using Flow-Sensitive Dephasing–prepared Steady-State Free Precession in Patients with Diabetes

Hepatocellular Carcinoma in Liver Transplantation Candidates: Detection with Gadobenate Dimeglumine–Enhanced MRI

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