Moxifloxacin—Warfarin Interaction: A Series of Five Case Reports

Elbe, Dean; Chang, Sandra

doi:10.1345/aph.1e179

Cited by 21 publications

(12 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moxifloxacin has been associated with enhancing the effect of warfarin [67]. A significant elevation in the prothrombin time can occur shortly (range, 3-7 days) after initiation of moxifloxacin therapy.…”

Section: Fluoroquinolonesmentioning

confidence: 99%

Safety of Newer Parenteral Antibiotics

Stein

2005

CLIN INFECT DIS

View full text Add to dashboard Cite

Several parenteral antimicrobials have been introduced into clinical practice over the course of the last decade. Some of these agents (e.g., linezolid, daptomycin, and tigecycline) are prototypes of new classes of compounds. In comparative clinical trials, these newer anti-infectives have been shown to be safe and to have low rates of discontinuation by patients. However, long-term use has revealed unique toxicities associated with the use of some of these drugs. The adverse events and potential drug interactions associated with the use of these antibiotics are variable and require familiarity with the safety profile of each drug. It is especially important that clinicians be able to recognize serious adverse events associated with the use of specific drugs, because most of the adverse events can be readily reversed by cessation of therapy.

show abstract

Section: Fluoroquinolonesmentioning

confidence: 99%

Safety of Newer Parenteral Antibiotics

Stein

2005

CLIN INFECT DIS

View full text Add to dashboard Cite

show abstract

“…[7] In addition, the risk also appears greater with concomitant use of penicillins, cephalosporins, carbapenems, theophylline, warfarin, and nonsteroidal anti-inflammatory drug. [689]…”

Section: Discussionmentioning

confidence: 99%

Moxifloxacin-induced acute psychosis: A case report with literature review

2016

View full text Add to dashboard Cite

Third generation quinolones are extensively used to treat a variety of common bacterial infections. Due to their extensive use in clinical practice, an increase in neuropsychiatric events has been reported. We report the case of psychotic symptoms occurs after three doses of moxifloxacin in a healthy adult male with no underlying risk factors. After the discontinuation of moxifloxacin treatment, there was a complete resolution of patient's symptoms. The case draws attention to a rare side effect of a commonly use drug and alert the clinicians to be cautious in those patients that have a baseline risk factors which makes the patient more susceptible to such adverse drug effect.

show abstract

“…17 Several postmarketing case reports, however, have suggested a possible drug interaction. [10][11][12][13] In these reports, the authors described a total of 11 cases where most of the patients appeared to have a stable anticoagulation regimen and experienced rapid elevations in their INR values after the initiation of moxifloxacin. Although many of the supratherapeutic INRs were recorded several days after the start of daily moxifloxacin, an interaction and steep rise in INRs could be seen even after the first dose of moxifloxacin was administered in four of these cases, 10,11 similar to what was observed in our patient.…”

Section: Discussionmentioning

confidence: 99%

“…Several reports have documented such elevations and potential interactions. [5][6][7][8][9][10][11][12][13] An elevated INR is associated with an increased risk of bleeding. Major bleeding, such as intracranial hemorrhaging, is associated with significant morbidity and mortality.…”

mentioning

confidence: 99%