Moxifloxacin–acetaminophen–warfarin interaction during bacille Calmette-Guérin treatment for bladder cancer

Lee, Roy; Wen, Alice; Berubé, Caroline

doi:10.2146/ajhp100159

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…), which could result in various drug–drug interactions. For example, a patient with bladder cancer who was receiving long‐term anticoagulant therapy showed supratherapeutic international normalized ratios after receiving concomitant APAP and moxifloxacin as prophylaxis with bacille Calmette‐Guérin therapy (Lee et al , ). In another case, APAP‐induced toxicity was enhanced by rifampicin‐activated human pregnane X receptor and CYP3A4 induction (Cheng et al , ).…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of acetaminophen and its six metabolites in rat plasma using liquid chromatography/tandem mass spectrometry

Lee

Jung

2012

Biomedical Chromatography

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Acetaminophen (APAP) is a widely used analgesic and antipyretic drug. It is mainly metabolized by phase 1 and 2 reactions in the liver, and thus it could be involved in many drug-drug interactions. Therefore, the study of APAP metabolism is important in toxicological and pharmacokinetic studies. The objective of this study was to develop a rapid and sensitive method for the determination of APAP and its six metabolites in rat plasma for the pharmacokinetic studies. APAP and its metabolites were separated through a Capcell Pak MGII C(18) column and quantitated with a 16 min run in a triple-quadruple mass spectrometer. The mobile phases were composed of 0.1% formic acid in either 95% water or 95% acetonitrile and analysis was performed twice in positive and negative modes. Validations such as accuracy, precision, recovery, matrix effect and stability were found to be within acceptance criteria of validation guidelines, indicating that the assay was applicable to the determination of the plasma concentrations of drug and its six metabolites. In conclusion, we developed an LC-MS/MS method for the quantitative analysis of APAP and its six metabolites in rat plasma, and this method appears to be useful for pharmacokinetic/toxicokinetic studies of APAP and its metabolites in rats.

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Section: Introductionmentioning

confidence: 99%

Quantitative analysis of acetaminophen and its six metabolites in rat plasma using liquid chromatography/tandem mass spectrometry

Lee

Jung

2012

Biomedical Chromatography

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Quinolones

Guay¹

2018

Drug Interactions in Infectious Diseases: Antimicrobial Drug Interactions

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Ascorbic acid interaction with phytol: a modulatory effects on the anti-pyretic activity of paracetamol in Swiss albino mice

et al. 2020

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Background Antioxidants have protective capacity, and can be used combinedly with other substances. Both, ascorbic acid (AA) and phytol (PHY) have many important biological activities, including antioxidant, anti-inflammatory, and organ protective activity. Recently, PHY has been found to exert an anti-pyretic effect in a mouse model. This study aims to evaluate the combined effects of AA and/or PHY with paracetamol (PARA) in Brewer’s yeast-induced fever mice model. Methods AA (125 mg/kg) and/or PHY (200 mg/kg) were orally co-treated with the PARA (100 mg/kg, p.o.) in Brewer’s yeast-induced fever Swiss mice. Data were analyzed by using GraphPadPrism software (version: 6.0), considering p < 0.05 at 95% confidence interval, and using one-way analysis of variance (ANOVA) through time, followed by Dunnett’s post hoc multiple comparison test. Results PARA alone and with PHY and/or AA significantly (p < 0.05) reduced rectal temperature at 1st h of observation. PHY reduced rectal temperature at 2nd h, then maintained basal temperature over the observation period (4 h). AA showed an insignificant anti-pyretic effect in experimental animals. However, in combination groups, AA (i.e., with PHY or PARA) did not found to interfere the PHY and PARA mediated reduction of rectal temperature in the animals. Furthermore, AA when co-treated with the PARA + PHY, it caused a slight hypothermic temperature at 1st h, which was then started to restablish from 2nd to 3rd h, and normalized at 4th h. Conclusion Taken together, AA did not interfere anti-pyretic effects of PARA and PHY, suggesting its possible use as a combination substance.

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Moxifloxacin–acetaminophen–warfarin interaction during bacille Calmette-Guérin treatment for bladder cancer

Abstract: An 89-year-old man receiving long-term anticoagulation with warfarin had supratherapeutic INRs after receiving acetaminophen and moxifloxacin as prophylaxis during BCG therapy for bladder cancer.

Cited by 3 publications

References 15 publications

Quantitative analysis of acetaminophen and its six metabolites in rat plasma using liquid chromatography/tandem mass spectrometry

Quantitative analysis of acetaminophen and its six metabolites in rat plasma using liquid chromatography/tandem mass spectrometry

Quinolones

Ascorbic acid interaction with phytol: a modulatory effects on the anti-pyretic activity of paracetamol in Swiss albino mice

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