Background: The news media play an essential role in shaping public opinion. Analyzing a specific issue reported in the news media provide insight and considerations for a government to form a policy. The study aimed to assess the portrayal of the electronic cigarette issue in Indonesian news media, including the variety of arguments being presented and the actors behind it.Methods: We used a paid service database from eBdesk to collect the Indonesian news articles from 2020 to 2021 using the keywords; 'rokok elektronik', 'rokok elektrik', 'e-rokok', 'vape' and 'vaping'. Content analysis of 551 full-text news articles was conducted to identify the concepts, topics, and frames of quoted arguments and to examine whether any frames were presented on the different types of organizations and the origin of actors. Results: News articles related to e-cigarettes were mostly published in the national newspaper and in the non-health section at the newspaper desk. A total of 891 arguments from 393 persons representing 212 institutions were identified. Twenty-eight concepts were further categorized into 12 topics. Health impact was the most frequently reported topic, followed by regulation, tax/price issues, and e-cigarettes as smoking cessation tools. Overall, the articles and arguments with positive tones toward e-cigarettes outnumbered negative articles and arguments. The industry, university and research-based institutions were the most involved type of organizations in the news articles report. There were more equal frames toward e-cigarettes among the international actors and government, even though the frame within the non-health government sector was reported to be more positive towards e-cigarettes.Conclusions: Although health impact is the most reported topic, the actors involved in delivering arguments were mainly from the non-health sector, including where the news articles were published on the newspaper desk. The E-cigarettes issue in Indonesia was mainly played by the non-health sector, which is more inclined toward economic interest than health.