Movement, mood and cognition: Preliminary insights into the therapeutic effects of electroconvulsive therapy for depression through a resting-state connectivity analysis

Belge, Jan-Baptist; Mulders, Peter; Oort, Jasper van; Diermen, Linda van; Poljac, Edita; Sabbe, Bernard; Timary, Philippe de; Constant, Éric; Sienaert, Pascal; Schrijvers, Didier; Eijndhoven, Philip van

doi:10.1016/j.jad.2021.04.069

Cited by 7 publications

(14 citation statements)

References 72 publications

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“…49 For example, patients with depression show increased connectivity in the DMN. 50,51 FNC was significantly decreased in the prefrontal region of the DMN and increased in the hippocampus in glioma patients, which was associated with tumor grade. 52 The results of our study indicate that the left MSFG (extending to the right MSFG) of the DMN was lower in the DON group than in HCs, suggesting that decreased FNC in the DMN is related to dysfunctional emotional cognition in DON.…”

Section: Intra-and Internetwork Comparisons Of Fncmentioning

confidence: 89%

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Graph theoretical analysis and independent component analysis of diabetic optic neuropathy: A resting‐state functional magnetic resonance imaging study

Wei,

Lin,

et al. 2024

CNS Neurosci Ther

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AimsThis study aimed to investigate the resting‐state functional connectivity and topologic characteristics of brain networks in patients with diabetic optic neuropathy (DON).MethodsResting‐state functional magnetic resonance imaging scans were performed on 23 patients and 41 healthy control (HC) subjects. We used independent component analysis and graph theoretical analysis to determine the topologic characteristics of the brain and as well as functional network connectivity (FNC) and topologic properties of brain networks.ResultsCompared with HCs, patients with DON showed altered global characteristics. At the nodal level, the DON group had fewer nodal degrees in the thalamus and insula, and a greater number in the right rolandic operculum, right postcentral gyrus, and right superior temporal gyrus. In the internetwork comparison, DON patients showed significantly increased FNC between the left frontoparietal network (FPN‐L) and ventral attention network (VAN). Additionally, in the intranetwork comparison, connectivity between the left medial superior frontal gyrus (MSFG) of the default network (DMN) and left putamen of auditory network was decreased in the DON group.ConclusionDON patients altered node properties and connectivity in the DMN, auditory network, FPN‐L, and VAN. These results provide evidence of the involvement of specific brain networks in the pathophysiology of DON.

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Section: Intra-and Internetwork Comparisons Of Fncmentioning

confidence: 89%

“…Altered connectivity in the DMN have been linked to mental disorders 49 . For example, patients with depression show increased connectivity in the DMN 50,51 . FNC was significantly decreased in the prefrontal region of the DMN and increased in the hippocampus in glioma patients, which was associated with tumor grade 52 .…”

Section: Discussionmentioning

confidence: 99%

Graph theoretical analysis and independent component analysis of diabetic optic neuropathy: A resting‐state functional magnetic resonance imaging study

Wei,

Lin,

et al. 2024

CNS Neurosci Ther

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“…Psychomotor retardation, a core symptom of depression, seems to be addressed by cortico-spinal connectivity, with higher FA values reflecting a compensatory mechanism in depressed patients [ 44 ]. With the potent impact of ECT on psychomotor symptoms in mind [ 45 ] future studies should further investigate the modulation of this pathway to comprehend the neurobiology behind these effects.…”

Section: Discussionmentioning

confidence: 99%

White matter changes following electroconvulsive therapy for depression: a multicenter ComBat harmonization approach

et al. 2022

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ECT is proposed to exert a therapeutic effect on WM microstructure, but the limited power of previous studies made it difficult to highlight consistent patterns of change in diffusion metrics. We initiated a multicenter analysis and sought to address whether changes in WM microstructure occur following ECT. Diffusion tensor imaging (DTI) data (n = 58) from 4 different sites were harmonized before pooling them by using ComBat, a batch-effect correction tool that removes inter-site technical variability, preserves inter-site biological variability, and maximizes statistical power. Downstream statistical analyses aimed to quantify changes in Fractional Anisotropy (FA), Mean Diffusivity (MD), Radial Diffusivity (RD) and Axial Diffusivity (AD), by employing whole-brain, tract-based spatial statistics (TBSS). ECT increased FA in the right splenium of the corpus callosum and the left cortico-spinal tract. AD in the left superior longitudinal fasciculus and the right inferior fronto-occipital fasciculus was raised. Increases in MD and RD could be observed in overlapping white matter structures of both hemispheres. At baseline, responders showed significantly smaller FA values in the left forceps major and smaller AD values in the right uncinate fasciculus compared with non-responders. By harmonizing multicenter data, we demonstrate that ECT modulates altered WM microstructure in important brain circuits that are implicated in the pathophysiology of depression. Furthermore, responders appear to present a more decreased WM integrity at baseline which could point toward a specific subtype of patients, characterized by a more altered neuroplasticity, who are especially sensitive to the potent neuroplastic effects of ECT.

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“…Psychomotor retardation, a core symptom of depression, seems to be addressed by cortico-spinal connectivity, with higher FA values re ecting a compensatory mechanism in depressed patients [41]. With the potent impact of ECT on psychomotor symptoms in mind [42] future studies should further investigate the modulation of this pathway to comprehend the neurobiology behind these effects.…”

Section: Longitudinal Effects Of Ect On Famentioning

confidence: 99%

White matter changes following electroconvulsive therapy for depression: a multicenter ComBat harmonization approach

Belge

Diermen

Schrijvers³

et al. 2022

Preprint

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ECT is proposed to exert a therapeutic effect on WM microstructure, but the limited power of previous studies made it difficult to highlight consistent patterns of change in diffusion metrics. We initiated a multicenter analysis and sought to address whether changes in WM microstructure occur following ECT. Diffusion tensor imaging (DTI) data (n = 58) from 4 different sites were harmonized before pooling them by using ComBat, a batch-effect correction tool that removes inter-site technical variability, preserves inter-site biological variability, and maximizes statistical power. Downstream statistical analyses aimed to quantify changes in Fractional Anisotropy (FA), Mean Diffusivity (MD), Radial Diffusivity (RD) and Axial Diffusivity (AD), by employing whole-brain, tract-based spatial statistics (TBSS). ECT increased FA in the right splenium of the corpus callosum and the left cortico-spinal tract. AD in the left superior longitudinal fasciculus and the right inferior fronto-occipital fasciculus was raised. Increases in MD and RD could be observed in overlapping white matter structures of both hemispheres. At baseline, responders showed significantly smaller FA values in the left forceps major and smaller AD values in the right uncinate fasciculus compared with non-responders. By harmonizing multicenter data, we demonstrate that ECT modulates altered WM microstructure in important brain circuits that are implicated in the pathophysiology of depression. Furthermore, responders appear to present a more decreased WM integrity at baseline which could point towards a specific subtype of patients, characterized by a more altered neuroplasticity, who are especially sensitive to the potent neuroplastic effects of ECT.

show abstract

Movement, mood and cognition: Preliminary insights into the therapeutic effects of electroconvulsive therapy for depression through a resting-state connectivity analysis

Cited by 7 publications

References 72 publications

Graph theoretical analysis and independent component analysis of diabetic optic neuropathy: A resting‐state functional magnetic resonance imaging study

Graph theoretical analysis and independent component analysis of diabetic optic neuropathy: A resting‐state functional magnetic resonance imaging study

White matter changes following electroconvulsive therapy for depression: a multicenter ComBat harmonization approach

White matter changes following electroconvulsive therapy for depression: a multicenter ComBat harmonization approach

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