Movement, imaging and neurobehavioral assessment as predictors of cerebral palsy in preterm infants

Constantinou, Janet C.; Adamson‐Macedo, Elvidina N.; Mirmiran, M.; Fleisher, Barry E.

doi:10.1038/sj.jp.7211664

Cited by 68 publications

(57 citation statements)

References 21 publications

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“…These findings corroborate a study 24 that used the NAPI neurobehavioural assessment. In the mentioned study, the authors found that in variables such as alertness and orientation, motor development and vigour and irritability, the delay in the items related to alertness and orientation was higher in the infants who developed cerebral palsy and had sequelae than in those who did not have any motor sequelae.…”

Section: Another Studysupporting

confidence: 81%

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Predictive models of early motor development in preterm infants: a longitudinal-prospective study

Formiga

Vieira

Facundes

et al. 2017

J. Hum. Growth Dev.

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Introduction: Preterm infants are vulnerable to developmental delays. Detecting problems at an early age is one of the challenges of professionals and researchers in the area. Objective: To analyse the motor development and to identify the risk factors associated with predictors of overall and motor delay in preterm newborns. Methods: Eighty preterm infants (50% female; mean gestational age = 33 ± 2.2 weeks) with low birth weight (average of 1,715 ± 437 g) were evaluated using the Neurobehavioral Assessment of the Preterm Infant (NAPI) during the neonatal phase (prior to term age), the Denver Developmental Screening Test II (DDST-II) between 2 and 8 months, the Test of Infant Motor Performance between 2 and 4 months regarding motor development and the Alberta Infant Motor Scale between 4 and 8 months. Results: Neurobehavioural delay was noted in 24% of the infants in the neonatal phase. Between 2 and 8 months, the delay in overall development was ≥ 31% and the delay in motor development was 35-36 %. Decreased levels of alertness, orientation, motor development and vigour according to the NAPI were shown to be predictive of a delay in development between 4 and 6 months of age. The delay in overall development between 2 and 6 months was predictive of a delay in motor development between 6 and 8 months. Conclusion: Neurobehavioural variables, hospital stay and overall delay are good predictors of motor development during the first year of age. Suggested citation: Formiga CKMR, Vieira MEB, Fagundes RR, Linhares MBM. Predictive models of early motor development in preterm infants: a longitudinal-prospective study. Keywords

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Section: Another Studysupporting

confidence: 81%

“…The validity and sensitivity of the NAPI are described using an index of neonatal clinical complications. The inter-rater reliability coefficient ranges from 0.67 to 0.97, sensitivity (75%) and specificity (69%) 24 .…”

Section: Neurobehavioral Assessment Of Preterm Infants (Napi)mentioning

confidence: 99%

Predictive models of early motor development in preterm infants: a longitudinal-prospective study

Formiga

Vieira

Facundes

et al. 2017

J. Hum. Growth Dev.

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“…Few studies have examined very early neurodevelopment prior to term-age [21][22][23][24]. The Neurobehavioral Assessment of Preterm Infants (NAPI) evaluates the neurodevelopment of preterm infants at b37 weeks of post-conceptional age, with predictive power for later development until the first 3 years of age and the early detection of cerebral palsy in combination with magnetic resonance imaging [22,25].…”

Section: Introductionmentioning

confidence: 99%

Neurobehavioral development prior to term-age of preterm infants and acute stressful events during neonatal hospitalization

Gorzilio

Garrido

Gaspardo

et al. 2015

Early Human Development

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“…The major consequences of this injury are permanent motor impairment (i.e., cerebral palsy [CP]) ranging from mild to profound spastic motor deficits [8][9][10][11][12][13], as well as a broad spectrum of cognitive, social behavioral, attentional, visual, and learning disabilities that manifest by school age in 25 to 50% of children [14][15][16][17][18]. In preterm survivors, magnetic resonance image (MRI)-defined WMI, but not gray matter injury manifests in the first months of life as abnormal movements that are predictive of CP [19][20][21]. The impact of WMI can be appreciated from a recent large population-based study of children with CP.…”

mentioning

confidence: 99%

The Instrumented Fetal Sheep as a Model of Cerebral White Matter Injury in the Premature Infant

et al. 2012

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Despite advances in neonatal intensive care, survivors of premature birth remain highly susceptible to unique patterns of developmental brain injury that manifest as cerebral palsy and cognitive-learning disabilities. The developing brain is particularly susceptible to cerebral white matter injury related to hypoxia-ischemia. Cerebral white matter development in fetal sheep shares many anatomical and physiological similarities with humans. Thus, the fetal sheep has provided unique experimental access to the complex pathophysiological processes that contribute to injury to the human brain during successive periods in development. Recent refinements have resulted in models that replicate major features of acute and chronic human cerebral injury and have provided access to complex clinically relevant studies of cerebral blood flow and neuroimaging that are not feasible in smaller laboratory animals. Here, we focus on emerging insights and methodologies from studies in fetal sheep that have begun to define cellular and vascular factors that contribute to white matter injury. Recent advances include spatially defined measurements of cerebral blood flow in utero, the definition of cellular maturational factors that define the topography of injury and the application of high-field magnetic resonance imaging to define novel neuroimaging signatures for specific types of chronic white matter injury. Despite the higher costs and technical challenges of instrumented preterm fetal sheep models, they provide powerful access to clinically relevant studies that provide a more integrated analysis of the spectrum of insults that appear to contribute to cerebral injury in human preterm infants.

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Movement, imaging and neurobehavioral assessment as predictors of cerebral palsy in preterm infants

Cited by 68 publications

References 21 publications

Predictive models of early motor development in preterm infants: a longitudinal-prospective study

Predictive models of early motor development in preterm infants: a longitudinal-prospective study

Neurobehavioral development prior to term-age of preterm infants and acute stressful events during neonatal hospitalization

The Instrumented Fetal Sheep as a Model of Cerebral White Matter Injury in the Premature Infant

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