Mouthwash With Alcohol and Oral Carcinogenesis: Systematic Review and Meta-analysis

Argemí, Ricard Aceves; Navarro, Beatriz González; García-Seisdedos, Paula Ochoa; Devesa, Albert Estrugo; López‐López, José

doi:10.1016/j.jebdp.2020.101407

Cited by 15 publications

(19 citation statements)

References 24 publications

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“…Both subgroups (users of mouthwash with high and low/no alcohol) showed similar results, well within the margin of error. This result was similar to that of Aceves Argemi et al, who found an OR of 1.48 (also not statistically significant) for users of high-alcohol mouthwashes [15]. Duration of mouthwash use was not associated with significantly increased SCCHN risk.…”

Section: Discussionsupporting

confidence: 90%

“…Gender differences were also minimal, with a 6% risk increase for women and a 0% risk increase for men (both not statistically significant). The result was similar to other meta-analyses in the field: Aceves Argemi et al found an OR of 1.057 (when not considering the presence of alcohol) [15], while Gandini et al found an RR of 1.13 [17]. These results may have been caused by either an inconsistent pattern of mouthwash use (the usage of different brands with varying alcoholic content, varying temporal consumption trends, etc.…”

Section: Discussionsupporting

confidence: 86%

“…Increased acetaldehyde levels cause disruptions of DNA synthesis and repair and the formation of stable DNA adducts-the binding of acetaldehyde to various proteins leads to structural and functional alterations of enzymes involved in DNA repair and methylation, and of proteins with anti-oxidative functions, such as glutathione [12]. Mouthwashes contain various other chemical agents that may cause irritation of the oral mucosa, including sweeteners and artificial colorings [15].…”

Section: Introductionmentioning

confidence: 99%

“…Gandini et al, in 2012, performed a meta-analysis that showed no statistically significant association between mouthwash use and the risk of oral cancer [17]. Aceves Argemi et al recently completed an updated meta-analysis, also failing to show a potential association between mouthwash use and an increased risk of oral cancer [15]. Many articles evaluating potential connections between mouthwash and SCCHN involved more granular analyses, considering the potential relationship between mouthwash use and the type of SCCHN or examining the risk of developing an SCCHN depending on the duration of use, the number of times per day the mouthwash was used, or its alcoholic content, as, even if overall the risk of SCCHN is not associated with mouthwash use, there might still be a clinically significant correlation in one or more subgroups.…”

Section: Introductionmentioning

confidence: 99%

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Mouthwash Use and the Risk of Oral, Pharyngeal, and Laryngeal Cancer. A Meta-Analysis

Hostiuc

Ionescu

Drima

2021

IJERPH

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Objective: The main aim of this study was to test whether the use of mouthwash is associated with subtypes of squamous cell carcinoma of the head and neck (SCCHN) and to test the potential risk of SCCHN depending on the mouthwash use duration, frequency, or alcoholic content. Materials and methods: We performed a meta-analysis using Web of Science and Scopus databases to detect the risk change associated with mouthwash use depending on the alcohol content, duration and frequency of use, and anatomical location. We used a random-effects model with the Sidik–Jonkman estimator for effect size model measures. Results: We included 17 studies in the meta-analysis containing 17,085 cases and 20,032 controls. The risk difference for SCCHN between mouthwash users and non-users was minimal, with a value of −0.02 [−0.05, 0.01]. Alcoholic mouthwash use was associated with a minimal decrease in risk (of −0.01 [−0.07, 0.05]). Frequent usage of mouthwash was associated with a statistically significant risk increase for SCCHN but the risk increase was marginal (0.04, [0.01, 0.06]). Conclusions: Overall, our study failed to show a statistically significant correlation between mouthwash use and the risk of SCCHN. The only statistically significant correlation that we could identify was between frequent usage and SCCHN, potentially caused by prolonged contact between some constituents of mouthwash (possibly alcohol) and the oral epithelium.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mouthwash Use and the Risk of Oral, Pharyngeal, and Laryngeal Cancer. A Meta-Analysis

Hostiuc

Ionescu

Drima

2021

IJERPH

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“…In vitro studies have shown that ethanol can increase the penetration of carcinogenic substances through the oral mucosa present in tobacco smoke [ 177 ]. Although the studies that have been undertaken so far failed to find a statistically significant association between mouthwash use and risk of oral cancer [ 178 , 180 , 181 ], mouthwash use may act as an effect modifier of tobacco smoking [ 180 ]. This is a major concern since tobacco smoking is considered the external factor with the greatest impact on the development and the progression of PD, being associated with high loads of periodontal pathogens, but also to impaired immune host responses and slow clinical healing processes [ 182 ].…”

Section: Bioactivity—oral Cavity Conditions As Targets Of Phenolicmentioning

confidence: 99%

Research Advances in the Use of Bioactive Compounds from Vitis vinifera By-Products in Oral Care

et al. 2020

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Oral health is considered an important factor of general health and it contributes to the quality of life. Despite the raising awareness of preventive measures, the prevalence of oral health conditions continues to increase. In this context, a growing interest in investigating natural resources like Vitis vinifera (V. vinifera) phenolic compounds (PhCs) as oral health promoters has emerged. This paper aims to review the evidence about the bioactivities of V. vinifera by-products in oral health. Up to date, a high number of studies have thoroughly reported the antimicrobial and antiplaque activity of V. vinifera extracts against S. mutans or in multi-species biofilms. Moreover, the bioactive compounds from V. vinifera by-products have been shown to modulate the periodontal inflammatory response and the underlying oxidative stress imbalance induced by the pathogenic bacteria. Considering these beneficial effects, the utility of V. vinifera by-products in the maintaining of oral health and the necessary steps towards the development of oral care products were emphasized. In conclusion, the high potential of V. vinifera by-products could be valorized in the development of oral hygiene products with multi-target actions in the prevention and progression of several oral conditions.

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Preprocedural mouthwashes for infection control in dentistry—an update

et al. 2023

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Objectives Aerosols and splatter are routinely generated in dental practice and can be contaminated by potentially harmful bacteria or viruses such as SARS-CoV-2. Therefore, preprocedural mouthwashes containing antiseptic agents have been proposed as a potential measure for infection control in dental practice. This review article aims to summarize the clinical (and, if insufficient, preclinical) evidence on preprocedural mouthwashes containing antiseptic agents and to draw conclusions for dental practitioners. Methods Literature on preprocedural mouthwashes for reduction of bacterial or viral load in dental aerosols was searched and summarized. Results Preprocedural mouthwashes, particularly those containing chlorhexidine digluconate (CHX), cetylpyridinium chloride (CPC), or essential oils (EO), can significantly reduce the bacterial load in dental aerosols. With respect to viruses such as HSV-1, there are too little clinical data to draw any clear recommendations. On the other hand, clinical data is consolidating that CPC-containing mouthwashes can temporarily reduce the intraoral viral load and infectivity in SARS-CoV-2 positive individuals. Nevertheless, potential risks and side effects due to regular antiseptic use such as ecological effects or adaptation of bacteria need to be considered. Conclusions The use of preprocedural mouthwashes containing antiseptics can be recommended according to currently available data, but further studies are needed, particularly on the effects on other viruses besides SARS-CoV-2. When selecting a specific antiseptic, the biggest data basis currently exists for CHX, CPC, EO, or combinations thereof. Clinical relevance Preprocedural mouthwashes containing antiseptics can serve as part of a bundle of measures for protection of dental personnel despite some remaining ambiguities and in view of potential risks and side effects.

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Mouthwash With Alcohol and Oral Carcinogenesis: Systematic Review and Meta-analysis

Cited by 15 publications

References 24 publications

Mouthwash Use and the Risk of Oral, Pharyngeal, and Laryngeal Cancer. A Meta-Analysis

Mouthwash Use and the Risk of Oral, Pharyngeal, and Laryngeal Cancer. A Meta-Analysis

Research Advances in the Use of Bioactive Compounds from Vitis vinifera By-Products in Oral Care

Preprocedural mouthwashes for infection control in dentistry—an update

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